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Overproduction of fatty acids in engineered Saccharomyces cerevisiae
The long hydrocarbon fatty acyl chain is energy rich, making it an ideal precursor for liquid transportation fuels and high‐value oleo chemicals. As Saccharomyces cerevisiae has many advantages forExpand
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Metabolic engineering of fatty acyl-ACP reductase-dependent pathway to improve fatty alcohol production in Escherichia coli.
Fatty alcohols are important components of surfactants and cosmetic products. The production of fatty alcohols from sustainable resources using microbial fermentation could reduce dependence onExpand
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Lipid engineering combined with systematic metabolic engineering of Saccharomyces cerevisiae for high-yield production of lycopene.
Saccharomyces cerevisiae is an efficient host for natural-compound production and preferentially employed in academic studies and bioindustries. However, S. cerevisiae exhibits limited productionExpand
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Targeted engineering and scale up of lycopene overproduction in Escherichia coli
Abstract Engineering microorganisms for production of terpenoids has attracted considerable attention, and initial success was achieved using traditional metabolic engineering strategies or highExpand
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Systematic metabolic engineering of Saccharomyces cerevisiae for lycopene overproduction.
Lycopene is widely used in foods, cosmetics, nutritional supplements, and pharmaceuticals. Microbial production of lycopene has been intensively studied. However, there are few systematic engineeringExpand
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In vitro reconstitution of mevalonate pathway and targeted engineering of farnesene overproduction in Escherichia coli
Approaches using metabolic engineering and synthetic biology to overproduce terpenoids, such as the precursors of taxol and artemisinin, in microbial systems have achieved initial success. However,Expand
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Genome mining of astaxanthin biosynthetic genes from Sphingomonas sp. ATCC 55669 for heterologous overproduction in Escherichia coli
As a highly valued keto‐carotenoid, astaxanthin is widely used in nutritional supplements and pharmaceuticals. Therefore, the demand for biosynthetic astaxanthin and improved efficiency ofExpand
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Streptomyces species: Ideal chassis for natural product discovery and overproduction.
There is considerable interest in mining organisms for new natural products (NPs) and in improving methods to overproduce valuable NPs. Because of the rapid development of tools and strategies forExpand
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Metabolic engineering of Escherichia coli for production of fatty acid short-chain esters through combination of the fatty acid and 2-keto acid pathways.
Fatty acid short-chain esters (FASEs) are biodiesels that are renewable, nontoxic, and biodegradable biofuels. A novel approach for the biosynthesis of FASEs has been developed usingExpand
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Production of taxadiene by engineering of mevalonate pathway in Escherichia coli and endophytic fungus Alternaria alternata TPF6.
Taxol (paclitaxel) is a diterpenoid compound with significant and extensive applications in the treatment of cancer. The production of Taxol and relevant intermediates by engineered microbes is anExpand
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