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tandutinib

Known as: 1-Piperazinecarboxamide, 4-(6-Methoxy-7-(3-(1-piperidinyl)propoxy)-4-quinazolinyl)-N-(4-(1-methylethoxy)phenyl)-, 4-(6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl)piperazine-1-carboxylic acid (4-isopropoxyphenyl)amide 
A piperazinyl quinazoline receptor tyrosine kinase inhibitor with antineoplastic activity. Tandutinib inhibits the autophosphorylation of FLT3 (FMS… 
National Institutes of Health

Related topics

Related topics

7 relations
FLT3 protein, humanMast/Stem Cell Growth Factor Receptor Kit, humanPlatelet-Derived Growth Factor Receptor Beta, HumanReceptor Tyrosine Kinase Inhibition

Narrower (1)

MLN-518

Broader (2)

PiperazinesQuinazolines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Synthesis of Novel Thieno[2,3-d]pyrimidine Derivatives and Evaluation of Their Cytotoxicity and EGFR Inhibitory Activity.
BACKGROUND 4-Substitutedaminoquinazoline scaffolds were reported to possess potent cytotoxic and EGFR inhibitory activity such as… 
2017
2017
Dual inhibition of Fes and Flt3 tyrosine kinases potently inhibits Flt3-ITD+ AML cell growth
Acute myelogenous leukemia (AML) is often associated with activating mutations in the receptor tyrosine kinase, Flt3, including… 
2016
2016
Feasibility and phase I trial of tandutinib in patients with recurrent glioblastoma.
2039 Background: Platelet-derived growth factor signaling is important in gliomagenesis and PDGFR-β is expressed on >90% of… 
2013
2013
Tandutinib (MLN518) reverses multidrug resistance by inhibiting the efflux activity of the multidrug resistance protein 7 (ABCC10)
It is well established that ATP-binding cassette (ABC) transporter-mediated multidrug resistance (MDR) is one of the major… 
2013
2013
FLT 3 Inhibitors for the Treatment of Acute Myeloid Leukemia
634. 42. Hexner EO, Serdikoff C, Jan M, et al. Lestaurtinib (CEP701) is a JAK2 inhibitor that suppresses JAK2/STAT5 signaling and… 
2012
2012
Preclinical Testing of Tandutinib in a Transgenic Medulloblastoma Mouse Model
Overexpression of platelet-derived growth factor receptor alpha (PDGFR-A) has been documented in association with primary tumors… 
2011
2011
Neuromuscular junction toxicity with tandutinib induces a myasthenic-like syndrome
Background: Tandutinib (MLN 518, Millennium Pharmaceuticals, Cambridge, MA) is an orally active multitargeted tyrosine kinase… 
Review
2011
Review
2011
Novel and emerging drugs for acute myeloid leukemia: pharmacology and therapeutic activity.
For the last twenty years, significant progress in Molecular and Cellular Biology has resulted in a better characterization and… 
Review
2010
Review
2010
FLT3 inhibitors for the treatment of acute myeloid leukemia.
The fms-like receptor tyrosine kinase-3 (FLT3), which is important for the normal development of hematopoietic stem cells and… 
2008
2008
Tandutinib inhibits FMS receptor signalling, and macrophage and osteoclast formation in vitro
Tandutinib inhibits FMS receptor signalling, and macrophage and osteoclast formation in vitro 
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