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tandutinib
Known as:
1-Piperazinecarboxamide, 4-(6-Methoxy-7-(3-(1-piperidinyl)propoxy)-4-quinazolinyl)-N-(4-(1-methylethoxy)phenyl)-
, 4-(6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl)piperazine-1-carboxylic acid (4-isopropoxyphenyl)amide
A piperazinyl quinazoline receptor tyrosine kinase inhibitor with antineoplastic activity. Tandutinib inhibits the autophosphorylation of FLT3 (FMS…
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National Institutes of Health
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Related topics
Related topics
7 relations
FLT3 protein, human
Mast/Stem Cell Growth Factor Receptor Kit, human
Platelet-Derived Growth Factor Receptor Beta, Human
Receptor Tyrosine Kinase Inhibition
Narrower (1)
MLN-518
Broader (2)
Piperazines
Quinazolines
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
FLT 3 Inhibitors for the Treatment of Acute Myeloid Leukemia
P. Wiernik
2013
Corpus ID: 37118967
634. 42. Hexner EO, Serdikoff C, Jan M, et al. Lestaurtinib (CEP701) is a JAK2 inhibitor that suppresses JAK2/STAT5 signaling and…
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2013
2013
Preparation method of tandutinib
许学农
2013
Corpus ID: 104583001
The invention discloses a preparation method of tandutinib (I). The preparation method comprises the step that 6-methoxy-7-(3…
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2013
2013
pharmacodynamics myelodysplastic syndrome: safety, pharmacokinetics, and antagonist, in patients with acute myelogenous leukemia or high-risk Phase 1 clinical results with tandutinib (MLN518), a…
S. Sheng
,
N. Holford
,
+12 authors
R. Paquette
2013
Corpus ID: 78562373
2012
2012
Abstract 5614: Tandutinib (MLN518/CT53518) targeted to stem-like cells by inhibiting the function of ATP-binding cassette subfamily G member 2
Wen-jing Deng
,
Chun-ling Dai
,
+7 authors
Zhesheng Chen
2012
Corpus ID: 76068690
2012
2012
Developing Drugs for Leukemia’s
T. Robak
2012
Corpus ID: 212447137
At present, available therapies are only partially effective in patients with leukemia and the vast majority of patients cannot…
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2011
2011
Abstract 4845: Tumor cell line profiling of eighteen cancer therapeutics to evaluate relationships between tumor genotypes and cancer cell sensitivities
Y. Ovechkina
,
C. O'Day
,
+9 authors
B. Nelson
2011
Corpus ID: 76088016
Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL In vitro cellular response profiling of tumor human…
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2010
2010
Gateways to clinical trials.
A. Tomillero
,
M. A. Moral
Methods and Findings in Experimental and Clinical…
2010
Corpus ID: 43025264
(-)-Epigallocatechin gallate, Abafungin, ACE-031, Adapalene/benzoyl peroxide, AE-37, Aflibercept, AGS-003, Albiglutide…
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2009
2009
C 6 glioma xenografts : An investigation using susceptibility contrast enhanced MRI and immunohistochemical methods
J. Boult
,
S. Walker-Samuel
,
D. Bradley
,
S. Robinson
2009
Corpus ID: 7395419
Introduction Glioblastoma multiforme (GBM) is heavily reliant upon angiogenesis for growth and represents one of the most…
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2009
2009
Chronic dosing with MLN0518 (Tandutinib), a small molecule PDGFR alpha/beta inhibitor, reduces tumor growth, hypoxia, and perfusion in 06 glioma xenografts: An investigation using immunohistochemical…
J. Boult
,
S. Walker-Samuel
,
D. Bradley
,
S. Robinson
2009
Corpus ID: 80867527
2006
2006
Short title: FLT3 antagonist tandutinib in AML or high-risk MDS
D. Angelo
,
R. Stone
,
+11 authors
M. Heinrich
2006
Corpus ID: 57729464
From the Dana Farber Cancer Institute, Boston, MA; Memorial Sloan Kettering Cancer Center, New York, NY; UCLA Medical Center, Los…
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