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MLN-518

Known as: CT-53518, CT53518, MLN518 
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Acquired resistance to selective FLT3 inhibitors is an emerging clinical problem in the treatment of FLT3-ITD+ acute myeloid… Expand
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Review
2010
Review
2010
  • P. Wiernik
  • Clinical advances in hematology & oncology : H&O
  • 2010
  • Corpus ID: 43049364
The fms-like receptor tyrosine kinase-3 (FLT3), which is important for the normal development of hematopoietic stem cells and… Expand
Highly Cited
2009
Highly Cited
2009
Activating mutations in the receptor tyrosine kinase FLT3 are present in up to approximately 30% of acute myeloid leukemia (AML… Expand
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Highly Cited
2009
Highly Cited
2009
http://bloodjournal.hematologylibrary.org/content/114/14/2984.full.html Updated information and services can be found at: (884… Expand
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Highly Cited
2006
Highly Cited
2006
Tandutinib (MLN518/CT53518) is a novel quinazoline-based inhibitor of the type III receptor tyrosine kinases: FMS-like tyrosine… Expand
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2005
2005
FMS-like tyrosine kinase 3 (FLT3) is a receptor tyrosine kinase that is constitutively activated in approximately 30% of acute… Expand
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Highly Cited
2004
Highly Cited
2004
FLT3 is constitutively activated by internal tandem duplications (ITDs) in the juxtamembrane domain or by activation loop… Expand
Highly Cited
2004
Highly Cited
2004
Oncogenic mutations of the receptor tyrosine kinase KIT occur in gastrointestinal stromal tumors (GISTs), some cases of acute… Expand
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Highly Cited
2002
Highly Cited
2002
Up to 30% of acute myelogenous leukemia (AML) patients harbor an activating internal tandem duplication (ITD) within the… Expand
Highly Cited
2002
Highly Cited
2002
We have previously found that the 4-[4-(N-substituted carbamoyl)-1-piperazinyl]-6,7-dimethoxyquinazolines can function as potent… Expand