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talotrexin

An antimetabolite analogue of aminopterin with potential antineoplastic activity. As a folate antagonist, talotrexin binds to and inhibits the… Expand
National Institutes of Health

Papers overview

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2016
2016
Abstract Talotrexin is an antifolate drug with promising antitumor activity. The present study deals with the photodegradation of… Expand
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2012
2012
Acute lymphocytic leukaemia (ALL) is a heterogeneous group of disorders that result from the clonal proliferation and expansion… Expand
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2009
2009
PurposeRenewed interest in antifols for the treatment of childhood cancers has resulted from identification of novel antifols… Expand
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Review
2007
Review
2007
Acute lymphocytic leukaemia (ALL) is a heterogeneous group of disorders that result from the clonal proliferation and expansion… Expand
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2007
2007
2210 Introduction. Talotrexin (PT-523) is an analog of aminopterin that cannot be polyglutamylated because it has a… Expand
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Review
2007
Review
2007
Acute lymphocytic leukemia (ALL) is a heterogeneous group of disorders that are associated with a cure rate of > 80% in children… Expand
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2006
2006
7142 Background: Talotrexin is a nonpolyglutamatable antifolate which has demonstrated improved antitumor activity in a broad… Expand
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2006
2006
Talvesta® is a novel, nonpolyglutamatable antifolate drug which has demonstrated improved antitumor activity in a broad spectrum… Expand
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2006
2006
Background. Talotrexin, Nα-(4-Amino-4-deoxypteroyl)-N5-hemiphthaloyl)-L-ornithine (PT-523) is a nonpolyglutamatable antifolate… Expand
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