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talotrexin

An antimetabolite analogue of aminopterin with potential antineoplastic activity. As a folate antagonist, talotrexin binds to and inhibits the… Expand
National Institutes of Health

Related topics

Related topics

4 relations
Dihydrofolate Reductase, humanPositive Regulation of Cell DeathPurine Synthesis Inhibition

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PT 523

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
PHOTOCHEMICAL ELECTRON TRANSFER REACTIONS OF TALOTREXIN
Abstract Talotrexin is an antifolate drug with promising antitumor activity. The present study deals with the photodegradation of… Expand
2012
2012
Treatment of Acute Lymphoblastic Leukaemia
Acute lymphocytic leukaemia (ALL) is a heterogeneous group of disorders that result from the clonal proliferation and expansion… Expand
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2009
2009
Clinical potency of methotrexate, aminopterin, talotrexin and pemetrexed in childhood leukemias
PurposeRenewed interest in antifols for the treatment of childhood cancers has resulted from identification of novel antifols… Expand
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Review
2007
Review
2007
Treatment of acute lymphoblastic leukaemia : a new era.
Acute lymphocytic leukaemia (ALL) is a heterogeneous group of disorders that result from the clonal proliferation and expansion… Expand
2007
2007
Combining talotrexin (PT-523) with paclitaxel in A549 non-small cell lung cancer (NSCLC) athymic nude mice xenografts
2210 Introduction. Talotrexin (PT-523) is an analog of aminopterin that cannot be polyglutamylated because it has a… Expand
Review
2007
Review
2007
Emerging therapeutic options for Philadelphia-positive acute lymphocytic leukemia
Acute lymphocytic leukemia (ALL) is a heterogeneous group of disorders that are associated with a cure rate of > 80% in children… Expand
2006
2006
A Phase I Study of Talvesta® (Talotrexin) in Relapsed or Refractory Leukemia or Myelodysplastic Syndrome.
Talvesta® is a novel, nonpolyglutamatable antifolate drug which has demonstrated improved antitumor activity in a broad spectrum… Expand
2006
2006
A phase I study of talotrexin (PT-523) in patients with relapsed or refractory non-small cell lung cancer (NSCLC).
7142 Background: Talotrexin is a nonpolyglutamatable antifolate which has demonstrated improved antitumor activity in a broad… Expand
2006
2006
464 POSTER Pharmacokinetics of talotrexin (PT-523), a novel aminopterin analogue, in patients with non-small cell lung cancer
Background. Talotrexin, Nα-(4-Amino-4-deoxypteroyl)-N5-hemiphthaloyl)-L-ornithine (PT-523) is a nonpolyglutamatable antifolate… Expand
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