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talotrexin
An antimetabolite analogue of aminopterin with potential antineoplastic activity. As a folate antagonist, talotrexin binds to and inhibits the…
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National Institutes of Health
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Related topics
Related topics
4 relations
Dihydrofolate Reductase, human
Positive Regulation of Cell Death
Purine Synthesis Inhibition
Narrower (1)
PT 523
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
PHOTOCHEMICAL ELECTRON TRANSFER REACTIONS OF TALOTREXIN
Anamika Gupta
,
W. Ahmad
,
J. Iqbal
,
M. Zaheer
2016
Corpus ID: 20815259
Abstract Talotrexin is an antifolate drug with promising antitumor activity. The present study deals with the photodegradation of…
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2012
2012
Treatment of Acute Lymphoblastic Leukaemia
Effrosyni Apostolidou
,
R. Swords
,
Y. Alvarado
,
F. Giles
Drugs
2012
Corpus ID: 46960055
Acute lymphocytic leukaemia (ALL) is a heterogeneous group of disorders that result from the clonal proliferation and expansion…
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2009
2009
Clinical potency of methotrexate, aminopterin, talotrexin and pemetrexed in childhood leukemias
R. Norris
,
P. Adamson
Cancer Chemotherapy and Pharmacology
2009
Corpus ID: 19439969
PurposeRenewed interest in antifols for the treatment of childhood cancers has resulted from identification of novel antifols…
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Review
2007
Review
2007
Treatment of acute lymphoblastic leukaemia : a new era.
Effrosyni Apostolidou
,
R. Swords
,
Y. Alvarado
,
F. Giles
Drugs
2007
Corpus ID: 27522690
Acute lymphocytic leukaemia (ALL) is a heterogeneous group of disorders that result from the clonal proliferation and expansion…
Expand
Review
2007
Review
2007
Emerging therapeutic options for Philadelphia-positive acute lymphocytic leukemia
Y. Alvarado
,
Effrosyni Apostolidou
,
R. Swords
,
F. Giles
Expert opinion on emerging drugs
2007
Corpus ID: 6006776
Acute lymphocytic leukemia (ALL) is a heterogeneous group of disorders that are associated with a cure rate of > 80% in children…
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2007
2007
Combining talotrexin (PT-523) with paclitaxel in A549 non-small cell lung cancer (NSCLC) athymic nude mice xenografts
G. Choy
,
W. Chao
,
D. Rizzieri
,
C. Rocha
,
Marissa Vargas Ramírez
,
G. Berk
2007
Corpus ID: 81586839
2210 Introduction. Talotrexin (PT-523) is an analog of aminopterin that cannot be polyglutamylated because it has a…
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2006
2006
A Phase I Study of Talvesta® (Talotrexin) in Relapsed or Refractory Leukemia or Myelodysplastic Syndrome.
F. Giles
,
D. Rizzieri
,
+4 authors
G. Berk
2006
Corpus ID: 78295315
Talvesta® is a novel, nonpolyglutamatable antifolate drug which has demonstrated improved antitumor activity in a broad spectrum…
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2006
2006
A phase I study of talotrexin (PT-523) in patients with relapsed or refractory non-small cell lung cancer (NSCLC).
C. S. R. Rocha Lima
,
S. Orlov
,
+7 authors
G. Berk
Journal of clinical oncology : official journal…
2006
Corpus ID: 37989326
7142 Background: Talotrexin is a nonpolyglutamatable antifolate which has demonstrated improved antitumor activity in a broad…
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2006
2006
464 POSTER Pharmacokinetics of talotrexin (PT-523), a novel aminopterin analogue, in patients with non-small cell lung cancer
G. Choy
,
Marianne Nabil Guirguis
,
M. Ramirez
,
G. Berk
2006
Corpus ID: 72790732
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