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talotrexin

An antimetabolite analogue of aminopterin with potential antineoplastic activity. As a folate antagonist, talotrexin binds to and inhibits the… 
National Institutes of Health

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Dihydrofolate Reductase, humanPositive Regulation of Cell DeathPurine Synthesis Inhibition

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PT 523

Papers overview

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2016
2016
PHOTOCHEMICAL ELECTRON TRANSFER REACTIONS OF TALOTREXIN
Abstract Talotrexin is an antifolate drug with promising antitumor activity. The present study deals with the photodegradation of… 
Review
2007
Review
2007
Emerging therapeutic options for Philadelphia-positive acute lymphocytic leukemia
Acute lymphocytic leukemia (ALL) is a heterogeneous group of disorders that are associated with a cure rate of > 80% in children… 
2007
2007
Combining talotrexin (PT-523) with paclitaxel in A549 non-small cell lung cancer (NSCLC) athymic nude mice xenografts
2210 Introduction. Talotrexin (PT-523) is an analog of aminopterin that cannot be polyglutamylated because it has a… 
2006
2006
A phase I study of talotrexin (PT-523) in patients with relapsed or refractory non-small cell lung cancer (NSCLC).
7142 Background: Talotrexin is a nonpolyglutamatable antifolate which has demonstrated improved antitumor activity in a broad… 
2006
2006
464 POSTER Pharmacokinetics of talotrexin (PT-523), a novel aminopterin analogue, in patients with non-small cell lung cancer
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