Skip to search formSkip to main contentSkip to account menu

PT 523

Known as: PT-523, PT523 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Folates are essential for brain development and function. Folate transport in mammalian tissues is mediated by three major folate… 
Highly Cited
2008
Highly Cited
2008
The reduced folate carrier (RFC) and the proton-coupled folate transporter (PCFT) are ubiquitously expressed in normal and… 
Highly Cited
2004
Highly Cited
2004
Studies were undertaken to characterize a low pH transport activity in a reduced folate carrier (RFC)-null HeLa-derived cell line… 
Highly Cited
2004
Highly Cited
2004
A methotrexate (MTX)-resistant HeLa subline (R5), developed in this laboratory, with impaired transport due to a genomic deletion… 
2002
2002
Pemetrexed is a novel antifolate effective in the treatment of mesothelioma. Studies were undertaken to characterize the… 
Highly Cited
2000
Highly Cited
2000
Cancer cell lines in standard cell culture medium or in animal models are surrounded by an environment with relatively high… 
1999
1999
Since the early 1950s, extensive research efforts have been devoted to the discovery and development of antifolate… 
1997
1997
The antitumor compound PT523 [N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L- ornithine] was found to have an… 
1994
1994
Studies on the mode of action of PT523 [N alpha-(4-amino-4-deoxypteroyl)-N delta-hemiphthaloyl-L-ornithine], a potent…