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PT 523
Known as:
PT-523
, PT523
National Institutes of Health
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Related topics
Related topics
1 relation
Broader (1)
talotrexin
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2007
2007
Combining talotrexin (PT-523) with paclitaxel in A549 non-small cell lung cancer (NSCLC) athymic nude mice xenografts
G. Choy
,
W. Chao
,
D. Rizzieri
,
C. Rocha
,
Marissa Vargas Ramírez
,
G. Berk
2007
Corpus ID: 81586839
2210 Introduction. Talotrexin (PT-523) is an analog of aminopterin that cannot be polyglutamylated because it has a…
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2005
2005
inactivating mutations and allele loss leukemia cells harboring three reduced folate carrier alleles : Coexistence of multiple mechanisms of PT 523-resistance in human
I. Ifergan
,
L. Rothem
,
G. Jansen
,
Y. Assaraf
2005
Corpus ID: 9508590
The reduced folate carrier (RFC) is the dominant route for the uptake of various antifolates including PT523, a potent…
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2004
2004
Pathway Association with the Presence of a Secondary Transport Activity in HeLa Cells Lacking the Reduced Folate Carrier : Selective Preservation of Pemetrexed Pharmacological
R. Zhao
,
M. Hanscom
,
S. Chattopadhyay
,
I. Goldman
2004
Corpus ID: 17586662
A methotrexate (MTX)-resistant HeLa subline (R5), developed in this laboratory, with impaired transport due to a genomic deletion…
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Review
1999
Review
1999
Enhancing cytotoxic sensitivity of tumor cells to antifolates: another opportunity for gene therapy?
F. Sirotnak
Journal of the National Cancer Institute
1999
Corpus ID: 6485291
Effective cytotoxic action of classical folate analogues against tumor cells(1,2)relies not only on their potent inhibition of…
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