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PT 523

Known as: PT-523, PT523 
 
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
The reduced folate carrier (RFC) and the proton-coupled folate transporter (PCFT) are ubiquitously expressed in normal and… Expand
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2006
2006
The reduced folate carrier (RFC) is the dominant route for the uptake of various antifolates including PT523, a potent… Expand
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Highly Cited
2004
Highly Cited
2004
Studies were undertaken to characterize a low pH transport activity in a reduced folate carrier (RFC)-null HeLa-derived cell line… Expand
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Highly Cited
2004
Highly Cited
2004
A methotrexate (MTX)-resistant HeLa subline (R5), developed in this laboratory, with impaired transport due to a genomic deletion… Expand
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Highly Cited
2002
Highly Cited
2002
We determined the mechanisms of resistance of human CCRF-CEM leukemia cells to methotrexate (MTX) vs. those to six novel… Expand
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2002
2002
Pemetrexed is a novel antifolate effective in the treatment of mesothelioma. Studies were undertaken to characterize the… Expand
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Highly Cited
2000
Highly Cited
2000
Cancer cell lines in standard cell culture medium or in animal models are surrounded by an environment with relatively high… Expand
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1999
1999
Since the early 1950s, extensive research efforts have been devoted to the discovery and development of antifolate… Expand
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1997
1997
The antitumor compound PT523 [N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L- ornithine] was found to have an… Expand
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1994
1994
Studies on the mode of action of PT523 [N alpha-(4-amino-4-deoxypteroyl)-N delta-hemiphthaloyl-L-ornithine], a potent… Expand
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