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PT 523
Known as:
PT-523
, PT523
National Institutes of Health
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Related topics
Related topics
1 relation
Broader (1)
talotrexin
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Regulation of Reduced Folate Carrier (RFC) by Vitamin D Receptor at the Blood-Brain Barrier.
C. Alam
,
Md. Tozammel Hoque
,
R. Finnell
,
I. Goldman
,
R. Bendayan
Molecular Pharmaceutics
2017
Corpus ID: 206687832
Folates are essential for brain development and function. Folate transport in mammalian tissues is mediated by three major folate…
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Highly Cited
2008
Highly Cited
2008
The Proton-Coupled Folate Transporter: Impact on Pemetrexed Transport and on Antifolates Activities Compared with the Reduced Folate Carrier
R. Zhao
,
A. Qiu
,
Eugenia Tsai
,
M. Jansen
,
M. Akabas
,
I. Goldman
Molecular Pharmacology
2008
Corpus ID: 10216910
The reduced folate carrier (RFC) and the proton-coupled folate transporter (PCFT) are ubiquitously expressed in normal and…
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Highly Cited
2004
Highly Cited
2004
Characterization of a Folate Transporter in HeLa Cells with a Low pH Optimum and High Affinity for Pemetrexed Distinct from the Reduced Folate Carrier
Yanhua Wang
,
R. Zhao
,
I. Goldman
Clinical Cancer Research
2004
Corpus ID: 23789942
Studies were undertaken to characterize a low pH transport activity in a reduced folate carrier (RFC)-null HeLa-derived cell line…
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Highly Cited
2004
Highly Cited
2004
Selective preservation of pemetrexed pharmacological activity in HeLa cells lacking the reduced folate carrier: association with the presence of a secondary transport pathway.
R. Zhao
,
M. Hanscom
,
S. Chattopadhyay
,
I. Goldman
Cancer Research
2004
Corpus ID: 10022341
A methotrexate (MTX)-resistant HeLa subline (R5), developed in this laboratory, with impaired transport due to a genomic deletion…
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Highly Cited
2002
Highly Cited
2002
Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemia cells and their implications for folate homeostasis.
R. Mauritz
,
G. Peters
,
+9 authors
G. Jansen
Biochemical Pharmacology
2002
Corpus ID: 25910818
2002
2002
A novel folate transport activity in human mesothelioma cell lines with high affinity and specificity for the new-generation antifolate, pemetrexed.
Yanhua Wang
,
R. Zhao
,
S. Chattopadhyay
,
I. Goldman
Cancer Research
2002
Corpus ID: 5233295
Pemetrexed is a novel antifolate effective in the treatment of mesothelioma. Studies were undertaken to characterize the…
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Highly Cited
2000
Highly Cited
2000
Folate depletion increases sensitivity of solid tumor cell lines to 5‐fluorouracil and antifolates
H. Backus
,
H. Pinedo
,
+6 authors
G. Peters
International Journal of Cancer
2000
Corpus ID: 22025905
Cancer cell lines in standard cell culture medium or in animal models are surrounded by an environment with relatively high…
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1999
1999
Preclinical Pharmacology Studies and the Clinical Development of a Novel Multitargeted Antifolate, MTA (LY231514)
C. Shih
,
D. Thornton
1999
Corpus ID: 69128704
Since the early 1950s, extensive research efforts have been devoted to the discovery and development of antifolate…
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1997
1997
NMR solution structure of the antitumor compound PT523 and NADPH in the ternary complex with human dihydrofolate reductase.
J. Johnson
,
E. Meiering
,
J. Wright
,
J. Pardo
,
A. Rosowsky
,
G. Wagner
Biochemistry
1997
Corpus ID: 18396204
The antitumor compound PT523 [N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L- ornithine] was found to have an…
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1994
1994
Biochemical studies on PT523, a potent nonpolyglutamatable antifolate, in cultured cells.
M. Rhee
,
J. Galivan
,
J. Wright
,
A. Rosowsky
Molecular Pharmacology
1994
Corpus ID: 6234835
Studies on the mode of action of PT523 [N alpha-(4-amino-4-deoxypteroyl)-N delta-hemiphthaloyl-L-ornithine], a potent…
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