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PT 523

Known as: PT-523, PT523 
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
The reduced folate carrier (RFC) and the proton-coupled folate transporter (PCFT) are ubiquitously expressed in normal and… Expand
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Highly Cited
2004
Highly Cited
2004
Studies were undertaken to characterize a low pH transport activity in a reduced folate carrier (RFC)-null HeLa-derived cell line… Expand
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Highly Cited
2004
Highly Cited
2004
A methotrexate (MTX)-resistant HeLa subline (R5), developed in this laboratory, with impaired transport due to a genomic deletion… Expand
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Highly Cited
2002
Highly Cited
2002
We determined the mechanisms of resistance of human CCRF-CEM leukemia cells to methotrexate (MTX) vs. those to six novel… Expand
2002
2002
Pemetrexed is a novel antifolate effective in the treatment of mesothelioma. Studies were undertaken to characterize the… Expand
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Highly Cited
2000
Highly Cited
2000
Cancer cell lines in standard cell culture medium or in animal models are surrounded by an environment with relatively high… Expand
1999
1999
Since the early 1950s, extensive research efforts have been devoted to the discovery and development of antifolate… Expand
1997
1997
The antitumor compound PT523 [N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L- ornithine] was found to have an… Expand
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Highly Cited
1997
Highly Cited
1997
Structural data for two independent crystal forms (monoclinic, C2, and orthorhombic, P2(1)2(1)2(1)) of the ternary complex of the… Expand
1994
1994
Studies on the mode of action of PT523 [N alpha-(4-amino-4-deoxypteroyl)-N delta-hemiphthaloyl-L-ornithine], a potent… Expand