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Dihydrofolate Reductase, human
Known as:
DHFR
, Dihydrofolate Reductase
, EC 1.5.1.3
Dihydrofolate reductase (187 aa, ~21 kDa) is encoded by the human DHFR gene. This protein is involved in folate metabolism and the synthesis of…
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National Institutes of Health
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Related topics
Related topics
12 relations
Anabolism
DHFR gene
Enzyme Gene
Folate Biosynthesis Pathway
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Broader (1)
Tetrahydrofolate Dehydrogenase
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
DHFR (dihydrofolate reductase)
Maja Krajinovic
,
Rachid Abaji
,
Bahram Sharif-Askari
2018
Corpus ID: 90653705
Dihydrofolate reductase (DHFR) is a member of the reductase enzyme family, which is ubiquitously expressed in all organisms…
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2018
2018
Co-Trimoxazole for Treatment of Pediculosis Capitis in Iraq
D. Abdulhussein
,
Dawood Salman Idan
2018
Corpus ID: 212553708
Background: In Iraq especially during the last decades, there was an increase of (HLI) causing more problems for doctors of Iraq…
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Review
2005
Review
2005
Stopped-flow NMR spectroscopy : Real-time unfolding studies of 6-19 F-tryptophan-labeled Escherichia coli dihydrofolate reductase ( unfolding intermediate / fluorescence / circular dichroism )
S. D. Hoeltzli
,
Carl Frieden
2005
Corpus ID: 45915036
Escherichia coli dihydrofolate reductase (DHFR; EC 1.5.1.3) contains five tryptophan residues that have been replaced with 6-19F…
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2004
2004
Contributions of Q67 and Y69 Residues to Ligand Binding and Catalysis in R67 Dihydrofolate Reductase
L. Stinnett
2004
Corpus ID: 86667048
Dihydrofolate reductase (DHFR) serves an important role in metabolism by reducing dihydrofolate (DHF) to the product…
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2003
2003
GLPFN IASYA TLVHIV AKCN LIPGD LIFSGGNTH IYMNHV EQCKE ILR REPKELYE LV ISGLPYKF RYLST KEQLKYVLK LRP KDFV LNNYVSHPP I KKMAV
S. Beverley
,
T. Ellenberger
,
J. S. Cordingley
2003
Corpus ID: 5798176
We have determined the nucleotide sequence of the dihydrofolate reductase-thymidylate synthetase (DHFRTS) gene of the protozoan…
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1993
1993
Kinetic investigation of methotrexate resistant human dihydrofolate reductase (hDHFR) mutants at Phe31.
S. Chunduru
,
J. Appleman
,
Raymond L. Blakley
Advances in Experimental Medicine and Biology
1993
Corpus ID: 36156801
Dihydrofolate reductase (DHFR) catalyzes the NADPH-dependent reduction of dihydrofolate (H2folate) to tetrahydrofolate (H4folate…
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1992
1992
Quantitation of dihydrofolate reductase and thymidylate synthase mRNAs in vivo and in vitro by polymerase chain reaction.
Dolnick Bj
,
Zhang Zg
,
Hines Jd
,
Rustum Ym
1992
Corpus ID: 196627158
: Rapid and quantitative polymerase chain reaction (PCR) assays based upon the competitive template technique have been developed…
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1977
1977
Methotrexate assay by enzymatic inhibition, with use of centrifugal analyzer.
P. Finley
,
R. Williams
Clinical Chemistry
1977
Corpus ID: 2634739
We present a method for measuring methotrexate by enzymatic inhibition, with use of the centrifugal analyzer. In the presence of…
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1974
1974
Characterization of New Regulatory Mutants of Bacteriophage T4
J. Johnson
,
D. Hall
Journal of Virology
1974
Corpus ID: 65735
Plating techniques which eliminate T4 plaque formation on Escherichia coli by folate analogue inhibition of dihydrofolate (FH2…
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1972
1972
The temporal expression of T2r + bacteriophage genes in vivo and in vitro.
R. B. Trimble
,
J. Galivan
,
F. Maley
Proceedings of the National Academy of Sciences…
1972
Corpus ID: 21790520
The kinetic order of synthesis of deoxycytidylate deaminase (EC 3.5.4.12), deoxycytidylate hydroxymethylase (EC 2.1.2.b…
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