Dihydrofolate Reductase, human

Known as: DHFR, Dihydrofolate Reductase, EC 1.5.1.3 
Dihydrofolate reductase (187 aa, ~21 kDa) is encoded by the human DHFR gene. This protein is involved in folate metabolism and the synthesis of… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1972-2018
051019722018

Papers overview

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2008
2008
Dihydrofolate reductase (DHFR) is the major target of methotrexate (MTX), a key component in childhood acute lymphoblastic… (More)
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Highly Cited
2003
Highly Cited
2003
Dihydrofolate reductase (DHFR) catalyzes the reduction of dihydrofolate to tetrahydrofolate. The catalytic rate in this system… (More)
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Highly Cited
1999
Highly Cited
1999
Two strategies are described for detecting constitutive or induced protein-protein interactions in intact mammalian cells; these… (More)
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1996
1996
Variants of dihydrofolate reductase (DHFR), which confer resistance to antifolates, are used as dominant selectable markers in… (More)
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1993
1993
Dihydrofolate reductase (DHFR) is a critical enzyme in de novo purine and thymidylate biosynthesis. An RNA gel mobility shift… (More)
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Highly Cited
1990
Highly Cited
1990
Cycloguanil, the active metabolite of the antimalarial drug proguanil, is an inhibitor of dihydrofolate reductase as is another… (More)
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1989
1989
Pneumocystis carinii dihydrofolate reductase (DHFR; 5,6,7,8-tetrahydrofolate: NADP+ oxidoreductase, EC 1.5.1.3) cDNA sequences… (More)
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Highly Cited
1988
Highly Cited
1988
We describe the isolation and the sequence of the gene for the bifunctional enzyme dihydrofolate reductase-thymidylate synthase… (More)
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Highly Cited
1980
Highly Cited
1980
Mutants of Chinese hamster ovary cells lacking dihydrofolate reductase (tetrahydrofolate dehydrogenase, 7,8-dihydrofolate:NADP… (More)
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Highly Cited
1979
Highly Cited
1979
Selection of mammalian cells in progressively increasing concentrations of methotrexate results in selective amplification of DNA… (More)
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