Positive Regulation of Cell Death

Known as: Cell Death Induction 
Any process that increases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that… (More)
National Institutes of Health

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ACER2 geneANP32B geneANP32B wt AlleleAlkaline Ceramidase 2
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Broader (1)

biological control

Papers overview

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Review
2017
Review
2017
Endoplasmic Reticulum Stress, Unfolded Protein Response, and Cancer Cell Fate
Perturbation of endoplasmic reticulum (ER) homeostasis results in a stress condition termed "ER stress" determining the… (More)
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Highly Cited
2006
Highly Cited
2006
hTERT: a novel endogenous inhibitor of the mitochondrial cell death pathway
hTERT is the catalytic subunit of the telomerase and is hence required for telomerase maintenance activity and cancer cell… (More)
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Review
2005
Review
2005
The ubiquitin-proteasome pathway and its role in cancer.
Critical cellular processes are regulated, in part, by maintaining the appropriate intracellular levels of proteins. Whereas de… (More)
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Highly Cited
2005
Highly Cited
2005
Fatty acid hydroperoxides and H2O2 in the execution of hypersensitive cell death in tobacco leaves.
We initially compared lipid peroxidation profiles in tobacco (Nicotiana tabacum) leaves during different cell death events. An… (More)
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Highly Cited
2004
Highly Cited
2004
New CFSE-based assay to determine susceptibility to lysis by cytotoxic T cells of leukemic precursor cells within a heterogeneous target cell population.
For the clinical evaluation of the efficacy of cellular immunotherapy it is necessary to analyze the effector functions of T… (More)
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Highly Cited
2001
Highly Cited
2001
Dominant cell death induction by extramitochondrially targeted apoptosis-inducing factor.
The complete AIF cDNA comprising the amino-terminal mitochondrial localization sequence (MLS) and the oxidoreductase domain has… (More)
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Highly Cited
1999
Highly Cited
1999
Caspase 3 inactivation to suppress Fas-mediated apoptosis: identification of binding domain with p21 and ILP and inactivation machinery by p21
The death mediator caspase acts as the dominant regulator during cell death induction. The CPP32 subfamily, including caspase 3… (More)
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Highly Cited
1998
Highly Cited
1998
Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.
Homozygous targeted disruption of the mouse Caspase 8 (Casp8) gene was found to be lethal in utero. The Caspase 8 null embryos… (More)
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Review
1997
Review
1997
Cell death induction by receptors of the TNF family: towards a molecular understanding.
 
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Review
1997
Review
1997
Cell death induction by TNF: a matter of self control.
 
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