tadalafil

Known as: Tadanafil, (6R,12AR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-(methylenedioxy)phenyl) pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione, (6R-trans)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione 
A carboline-based compound with vasodilatory activity. Tadalafil selectively inhibits the cyclic guanosine monophosphate (cGMP)-specific type 5… (More)
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
BACKGROUND Data on the effect of initial combination therapy with ambrisentan and tadalafil on long-term outcomes in patients… (More)
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Highly Cited
2012
Highly Cited
2012
BACKGROUND Tadalafil improved lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH; LUTS/BPH) in… (More)
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Highly Cited
2009
Highly Cited
2009
BACKGROUND Treatment options for pulmonary arterial hypertension target the prostacyclin, endothelin, or nitric oxide pathways… (More)
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Highly Cited
2009
Highly Cited
2009
BACKGROUND Tadalafil is a novel long-acting inhibitor of phosphodiesterase-5. Because cGMP-dependent protein kinase (PKG… (More)
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Highly Cited
2008
Highly Cited
2008
PURPOSE Phosphodiesterase type 5 inhibitors are widely used to treat erectile dysfunction. Preliminary data have suggested… (More)
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Highly Cited
2007
Highly Cited
2007
OBJECTIVES To determine whether a long-term single daily oral dose of a longer half-life phosphodiesterase-5 (PDE5) inhibitor… (More)
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Highly Cited
2006
Highly Cited
2006
AIMS To characterize tadalafil plasma pharmacokinetics in healthy subjects following single and multiple doses. METHODS… (More)
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Highly Cited
2003
Highly Cited
2003
OBJECTIVES To examine the therapeutic effects of tadalafil on erectile dysfunction (ED) at 24 and 36 hours after dosing… (More)
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Highly Cited
2002
Highly Cited
2002
OBJECTIVE To evaluate the efficacy and safety of tadalafil taken as needed before sexual activity by men with diabetes and… (More)
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Highly Cited
2002
Highly Cited
2002
PURPOSE We conducted integrated analyses of the efficacy and safety of tadalafil, a potent, selective phosphodiesterase 5… (More)
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