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Sildenafil citrate

Known as: 1-((3-(6,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-d)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methylpiperazine citrate, Citrate, Sildenafil, Sildenafil Citrate [Chemical/Ingredient] 
The citrate salt of a pyrazolopyrimidinone derivative structurally related to zaprinast. Sildenafil selectively inhibits cyclic guanosine… 
National Institutes of Health

Related topics

Related topics

34 relations
12.5 ML sildenafil 0.8 MG/ML InjectionAcetildenafilDesmethyl SildenafilDrug Allergy

Narrower (5)

HomosildenafilNCX-911RevatioUK 92480-10

Broader (4)

Phosphodiesterase 5 inhibitorUrological AgentsVasodilator Agentssildenafil

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
A Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging Study of Oral Sildenafil Citrate in Treatment-Naive Children With Pulmonary Arterial Hypertension
Background— Safe, effective therapy is needed for pediatric pulmonary arterial hypertension. Methods and Results— Children (n=235… 
Review
2008
Review
2008
Randomized, double-blind, placebo-controlled study of postoperative nightly sildenafil citrate for the prevention of erectile dysfunction after bilateral nerve-sparing radical prostatectomy
Four weeks after bilateral nerve-sparing radical retropubic prostatectomy, men with normal erectile function before surgery were… 
Highly Cited
2005
Highly Cited
2005
Sildenafil citrate therapy for pulmonary arterial hypertension.
BACKGROUND Sildenafil inhibits phosphodiesterase type 5, an enzyme that metabolizes cyclic guanosine monophosphate, thereby… 
Highly Cited
2002
Highly Cited
2002
Sildenafil (Viagra) induces powerful cardioprotective effect via opening of mitochondrial K(ATP) channels in rabbits.
Sildenafil citrate (Viagra) is the pharmacological agent used to treat erectile dysfunction in men. Because this drug has a… 
Highly Cited
2002
Highly Cited
2002
Pharmacokinetics of sildenafil after single oral doses in healthy male subjects: absolute bioavailability, food effects and dose proportionality.
AIMS To determine the absolute bioavailability, dose proportionality and the effects of food on the pharmacokinetics of single… 
Highly Cited
2002
Highly Cited
2002
Efficacy and safety of sildenafil citrate in women with sexual dysfunction associated with female sexual arousal disorder.
OBJECTIVE Sildenafil citrate (Viagra Pfizer, New York, NY) is indicated for the treatment of erectile dysfunction in men. The… 
Highly Cited
1999
Highly Cited
1999
Sildenafil for treatment of erectile dysfunction in men with diabetes: a randomized controlled trial. Sildenafil Diabetes Study Group.
CONTEXT Erectile dysfunction is common in men with diabetes. OBJECTIVE To assess the efficacy and safety of oral sildenafil… 
Highly Cited
1999
Highly Cited
1999
Diagnostic evaluation of the erectile function domain of the International Index of Erectile Function.
Highly Cited
1999
Highly Cited
1999
Effects of sildenafil citrate on human hemodynamics.
Highly Cited
1998
Highly Cited
1998
Clinical safety of oral sildenafil citrate (VIAGRATM) in the treatment of erectile dysfunction
Sildenafil citrate has been shown to be effective in a wide range of patients with erectile dysfunction and has been approved in… 
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