sildenafil

Known as: 1-((3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-D)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methylpiperazine 
A drug used to treat erectile dysfunction. Sildenafil relaxes the smooth muscle of the penis to allow increased blood flow and erection. It is a type… (More)

Topic mentions per year

Topic mentions per year

1983-2017
020040019832017

Papers overview

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Highly Cited
2008
Highly Cited
2008
BACKGROUND Oral sildenafil and intravenous epoprostenol have independently been shown to be effective in patients with pulmonary… (More)
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Highly Cited
2007
Highly Cited
2007
BACKGROUND Patients with systolic heart failure (HF) who develop secondary pulmonary hypertension (PH) have reduced exercise… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Sildenafil inhibits phosphodiesterase type 5, an enzyme that metabolizes cyclic guanosine monophosphate, thereby… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Sildenafil, a phosphodiesterase-5 inhibitor, induces cardioprotection against ischemia/reperfusion injury via opening… (More)
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Highly Cited
2002
Highly Cited
2002
BACKGROUND The prognosis of patients with severe pulmonary hypertension (PHT) is poor. To determine prognosis and guide therapy… (More)
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Highly Cited
2002
Highly Cited
2002
BACKGROUND Lung fibrosis can be complicated by pulmonary hypertension, limiting exercise tolerance and life expectancy… (More)
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Highly Cited
2002
Highly Cited
2002
BACKGROUND Inhalation of the stable prostacyclin analogue iloprost is being studied for treatment of pulmonary hypertension. The… (More)
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Highly Cited
2001
Highly Cited
2001
BACKGROUND This study investigated the effect of the phosphodiesterase 5 inhibitor sildenafil on the pulmonary vascular response… (More)
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Highly Cited
1998
Highly Cited
1998
BACKGROUND Sildenafil is a potent inhibitor of cyclic guanosine monophosphate hydrolysis [corrected] in the corpus cavernosum and… (More)
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Highly Cited
1996
Highly Cited
1996
Sildenafil (Viagra, UK-92,480) is a novel oral agent under development for the treatment of penile erectile dysfunction. Erection… (More)
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