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Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans Affairs High-Density Lipoprotein Cholesterol Intervention…
Gemfibrozil therapy resulted in a significant reduction in the risk of major cardiovascular events in patients with coronary disease whose primary lipid abnormality was a low HDL cholesterol level, suggesting that the rate of coronary events is reduced by raising HDL cholesterol levels and lowering levels of triglycerides without lowering LDL cholesterol levels.
The Association of Registered Nurse Staffing Levels and Patient Outcomes: Systematic Review and Meta-Analysis
- R. Kane, T. Shamliyan, C. Mueller, S. Duval, T. Wilt
- Medicine, Political ScienceMedical care
- 1 December 2007
Increased RN staffing was associated with lower hospital related mortality in intensive care units (ICUs) and lower odds of hospitalrelated mortality and adverse patient events and patient and hospital characteristics, including hospitals’ commitment to quality of medical care, likely contribute to the actual causal pathway.
Noninvasive Treatments for Acute, Subacute, and Chronic Low Back Pain: A Clinical Practice Guideline From the American College of Physicians.
- A. Qaseem, T. Wilt, R. McLean, M. Forciea
- Medicine, PsychologyAnnals of internal medicine
- 4 April 2017
Clinicians should only consider opioids as an option in patients who have failed the aforementioned treatments and only if the potential benefits outweigh the risks for individual patients and after a discussion of known risks and realistic benefits with patients.
Integration of mental health/substance abuse and primary care.
- M. Butler, R. Kane, T. Wilt
- Medicine, PsychologyEvidence report/technology assessment
- 1 November 2008
There is a reasonably strong body of evidence to encourage integrated care, at least for depression, and there is no discernible effect of integration level, processes of care, or combination on patient outcomes for mental health services in primary care settings.
Diagnosis and Management of Stable Chronic Obstructive Pulmonary Disease: A Clinical Practice Guideline Update from the American College of Physicians, American College of Chest Physicians, American…
The value of history and physical examination for predicting airflow obstruction; the value of spirometry for screening or diagnosis of COPD; and COPD management strategies, specifically evaluation of various inhaled therapies, pulmonary rehabilitation programs, and supplemental oxygen therapy are addressed.
Immunotherapy for advanced renal cell cancer.
- C. Coppin, F. Porzsolt, A. Awa, J. Kumpf, A. Coldman, T. Wilt
- MedicineThe Cochrane database of systematic reviews
- 29 December 2015
It has been established that reduced doseinterleukin-2 given by intravenous bolus or by subcutaneous injection provides equivalent survival to high dose interleuk in-2 with less toxicity, and results indicate that interferon-alfa is superior to controls.
Radical prostatectomy versus observation for localized prostate cancer.
Among men with localized prostate cancer detected during the early era of PSA testing, radical prostatectomy did not significantly reduce all-cause or prostate-cancer mortality, as compared with observation, through at least 12 years of follow-up.
Conducting quantitative synthesis when comparing medical interventions: AHRQ and the Effective Health Care Program.
Systematic Review: Comparative Effectiveness and Harms of Treatments for Clinically Localized Prostate Cancer
- T. Wilt, R. MacDonald, I. Rutks, T. Shamliyan, B. Taylor, R. Kane
- MedicineAnnals of Internal Medicine
- 18 March 2008
The comparative short- and long-term benefits and harms of therapies for clinically localized prostate cancer and how patient and tumor characteristics affect the outcomes of these therapies, overall and differentially are determined.
Follow‐up of Prostatectomy versus Observation for Early Prostate Cancer
After nearly 20 years of follow‐up among men with localized prostate cancer, surgery was not associated with significantly lower all‐cause or prostate‐cancer mortality than observation and treatment was primarily for asymptomatic, local, or biochemical (prostate‐specific antigen) progression.