Desmethyl Sildenafil

Known as: Desmethylsildenafil, Sildenafil, Desmethyl 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1978-2018
012319782018

Papers overview

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2014
2014
PURPOSE To overcome cytochrome P450 2D6 (CYP2D6) mediated tamoxifen resistance in postmenopausal early breast cancer, CYP2D6… (More)
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2012
2012
TMC207 is a first-in-class diarylquinoline with a new mode of action against mycobacteria targeting the ATP synthase. It is… (More)
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2010
2010
OBJECTIVE To describe the pharmacokinetics and exposure of oral sildenafil (SIL) in neonates (2-5 kg) with pulmonary hypertension… (More)
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Highly Cited
2009
Highly Cited
2009
Tamoxifen has been the most important therapeutic agent for the treatment of estrogen receptor (ER)-positive breast cancer for… (More)
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2009
2009
OBJECTIVES It has been reported that hepatic cytochrome P450 (CYP)2C9 and CYP3A4 are responsible for the metabolism of sildenafil… (More)
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Highly Cited
2005
Highly Cited
2005
AIMS To determine whether bosentan decreases the plasma concentration of sildenafil in patients with pulmonary arterial… (More)
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Highly Cited
2004
Highly Cited
2004
The antiestrogen tamoxifen is extensively metabolized in patients to form a series of compounds with altered affinity for… (More)
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2002
2002
A liquid chromatography-tandem mass spectrometry method was developed for the analysis of sildenafil (SIL) and its metabolite… (More)
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1996
1996
Pharmacokinetic drug interactions involving the calcium channel blocker diltiazem (DTZ) have been attributed to inhibition of… (More)
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1995
1995
A single oral dose of 90 mg kg-1 chlorimipramine or chlorpromazine, corresponding to 54.5 or 55.9 mumol, respectively, was given… (More)
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