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A classification system to assess the crystallization tendency of organic molecules from undercooled melts.
Assessing the viability of an amorphous formulation strategy is of great importance in an era of drug discovery where a large percentage of new molecules have solubility limited dissolution rates,Expand
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Theoretical and Practical Approaches for Prediction of Drug–Polymer Miscibility and Solubility
PurposeCrystallization of drugs formulated in the amorphous form may lead to reduced apparent solubility, decreased rate of dissolution and bioavailability and compromise the physical integrity ofExpand
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Estimation of Drug–Polymer Miscibility and Solubility in Amorphous Solid Dispersions Using Experimentally Determined Interaction Parameters
PurposeThe amorphous form of a drug may provide enhanced solubility, dissolution rate, and bioavailability but will also potentially crystallize over time. Miscible polymeric additives provide aExpand
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Spectroscopic Characterization of Interactions Between PVP and Indomethacin in Amorphous Molecular Dispersions
AbstractPurpose. To study the molecular structure of indomethacin-PVP amorphous solid dispersions and identify any specific interactions between the components using vibrational spectroscopy.Expand
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Evaluation of amorphous solid dispersion properties using thermal analysis techniques.
Amorphous solid dispersions are an increasingly important formulation approach to improve the dissolution rate and apparent solubility of poorly water soluble compounds. Due to their complexExpand
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Influence of different polymers on the crystallization tendency of molecularly dispersed amorphous felodipine.
The ability of various polymers to inhibit the crystallization of amorphous felodipine was studied in amorphous molecular dispersions. Spin-coated films of felodipine with poly(vinylpyrrolidone)Expand
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Effect of polymer type on the dissolution profile of amorphous solid dispersions containing felodipine.
Amorphous solid dispersions are used as a strategy to improve the bioavailability of poorly water-soluble compounds. When formulating with a polymer, it is important not only for the polymer toExpand
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Understanding the Behavior of Amorphous Pharmaceutical Systems during Dissolution
PurposeTo investigate the underlying physical processes taking place during dissolution of amorphous pharmaceuticals and correlate them to the observed solution concentration-time profiles.Expand
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Dissolution and precipitation behavior of amorphous solid dispersions.
Amorphous solid dispersions (ASDs) are widely utilized in the pharmaceutical industry for bioavailability enhancement of low solubility drugs. The important factors governing the dissolution behaviorExpand
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Crystallization tendency of active pharmaceutical ingredients following rapid solvent evaporation--classification and comparison with crystallization tendency from undercooled melts.
In this study, the crystallization behavior of a variety of compounds was studied following rapid solvent evaporation using spin coating. Initial screening to determine model compound suitability wasExpand
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