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steganacin

National Institutes of Health

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4-ButyrolactoneLignans
analogs & derivatives

Papers overview

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2017
2017
United States Patent ( 19 ) Kende et al . 54 SYNTHESIS OF STEGANACIN AND DERIVATIVES THEREOF
(56) References Cited PUBLICATIONS Becker et al., J. Chem. Soc., Chem. Commun., pp. 430-431 (1974). Hughes et al., Tetrahedron… 
2007
2007
Gupta Inhibitors and Podophyllotoxin Analogues Cells : Cross-Resistance Studies with Various Microtubule Podophyllotoxin-resistant Mutants of Chinese Hamster Ovary
The cross-resistances of several mutants of Chinese hamster ovary cells which have been obtained after one and two selection… 
2003
2003
Novel B-ring modified allocolchicinoids of the NCME series: design, synthesis, antimicrotubule activity and cytotoxicity.
Highly Cited
1996
Highly Cited
1996
Computational and molecular modeling evaluation of the structural basis for tubulin polymerization inhibition by colchicine site agents.
1993
1993
Novel antimitotic dibenzocyclo-octadiene lignan constituents of the stem bark of Steganotaenia araliacea.
By means of activity-directed chromatographic fractionation using cultured astrocytoma (ASK) cells, six dibenzocyclo-octadiene… 
1991
1991
Absolute structure-cytotoxic activity relationships of steganacin congeners and analogues.
The cytotoxic activities of optically pure and racemic steganacin congeners and analogues against KB cells in culture and the… 
1986
1986
Stereoselective reactions. XII. Synthesis of antitumor-active steganacin analogs, picrosteganol and epipicrosteganol, by selective isomerization.
New steganacin analogs with definite absolute configurations, (-)-picro- and (-)-epipicrosteganol, were synthesized by… 
1981
1981
Peptides of the Pars Intermedia. Ciba Foundation Symposium 81
new directions in drug design are the contributions by Dr. Sartorelli and Dr. R.H. Abeles. Dr. Sartorelli's innovative approach… 
Highly Cited
1980
Highly Cited
1980
Structure--antitubulin activity relationship in steganacin congeners and analogues. Inhibition of tubulin polymerization in vitro by (+/-)-isodeoxypodophyllotoxin.
A new series of 23 synthetic analogues of the naturally occurring antitumor lignan steganacin was tested for the inhibition of… 
1978
1978
Steganacin: an inhibitor of HeLa cell growth and microtubule assembly in vitro.
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