steganacin
National Institutes of Health
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The asymmetric synthesis of novel axially chiral biaryl compounds 5 a-f containing a seven- or eight-membered heterocyclic medium…
The cytotoxic activities of optically pure and racemic steganacin congeners and analogues against KB cells in culture and the…
A highly efficient synthesis of the antitumor steganin lignan steganacin (1) was accomplished. Bromination of stegane (7) with N…
A new series of 23 synthetic analogues of the naturally occurring antitumor lignan steganacin was tested for the inhibition of…
Steganacin, a newly isolated tumor inhibitor, completely inhibits cleavage in sea urchin eggs at 3 X 10(-7) M by preventing the…