steganacin

The asymmetric synthesis of novel axially chiral biaryl compounds 5 a-f containing a seven- or eight-membered heterocyclic medium… Expand

Steganacin and podophyllotoxin are two naturally occurring lignans first isolated from plant sources, which share the capability… Expand

The computer-automated structure evaluation programs MultiCASE and CASE were used to perform a quantitative structure-activity… Expand

The cytotoxic activities of optically pure and racemic steganacin congeners and analogues against KB cells in culture and the… Expand

The novel agents amphethinile and combretastatin A4 are shown to be very similar to colchicine in their interactions with… Expand

New steganacin analogs with definite absolute configurations, (-)-picro- and (-)-epipicrosteganol, were synthesized by… Expand

The cross-resistances of several mutants of Chinese hamster ovary cells which have been obtained after one and two selection… Expand

A new series of 23 synthetic analogues of the naturally occurring antitumor lignan steganacin was tested for the inhibition of… Expand

The plant derivative steganacin, an antitumor compound, blocks the replication of HeLa cells in mitosis. Steganacin inhibits… Expand

Steganacin, a newly isolated tumor inhibitor, completely inhibits cleavage in sea urchin eggs at 3 X 10(-7) M by preventing the… Expand