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src-Family Kinases

Known as: Tyrosine Kinases, src-Family, Kinases, src, src Protein-Tyrosine Kinases 
A PROTEIN-TYROSINE KINASE family that was originally identified by homology to the Rous sarcoma virus ONCOGENE PROTEIN PP60(V-SRC). They interact… 
National Institutes of Health

Related topics

Related topics

32 relations

Narrower (9)

BLK protein, humanFrk protein, mouseLymphocyte Specific Protein Tyrosine Kinase p56(lck)SRMS protein, human
Cell Differentiation processCell ProliferationEnzyme GeneGenes, src

Papers overview

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Highly Cited
2005
Highly Cited
2005
Cholesterol depletion inhibits src family kinase‐dependent calcium mobilization and apoptosis induced by rituximab crosslinking
The monoclonal antibody (mAb) rituximab produces objective clinical responses in patients with B‐cell non‐Hodgkin's lymphoma and… 
Highly Cited
1999
Highly Cited
1999
Novel association of the src family kinases, hck and c-fgr, with CCR3 receptor stimulation: A possible mechanism for eotaxin-induced human eosinophil chemotaxis.
The chemokine eotaxin is a potent and relatively eosinophil-specific chemoattractant implicated in the cell migration to… 
Highly Cited
1998
Highly Cited
1998
Syk activation is required for spreading and H2O2 release in adherent human neutrophils.
Chemoattractant-stimulated polymorphonuclear leukocytes (PMNs) that are adherent to extracellular matrix proteins exhibit a… 
Highly Cited
1998
Highly Cited
1998
Signaling through the tetraspanin CD82 triggers its association with the cytoskeleton leading to sustained morphological changes and T cell activation
In this report, we provide new evidence of a crosstalk between T cell activation and adhesion processes through a functional… 
1998
1998
Formation of a stable src–AFAP‐110 complex through either an amino‐terminal or a carboxy‐terminal SH2‐binding motif
The actin‐filament–associated protein (AFAP‐110) forms a stable complex with activated variants of the Pp60c‐src (Src) non… 
Highly Cited
1996
Highly Cited
1996
Mutational analysis of Lck in CD45-negative T cells: dominant role of tyrosine 394 phosphorylation in kinase activity
The CD45 tyrosine phosphatase has been reported to activate the src family tyrosine kinases Lck and Fyn by dephosphorylating… 
Highly Cited
1993
Highly Cited
1993
Phospholipase C-gamma 1 associates with viral and cellular src kinases.
Highly Cited
1989
Highly Cited
1989
High pp60c-src level in human platelet dense bodies.
Phosphoproteins phosphorylated in vivo were examined in resting and thrombin-activated human blood platelets. Thrombin… 
1989
1989
Nonphosphorylatable substrate analogs selectively block autophosphorylation and activation of the insulin receptor, epidermal growth factor receptor, and pp60v-src kinases.
Highly Cited
1987
Highly Cited
1987
Alterations in pp60c-src accompany differentiation of neurons from rat embryo striatum
Cultured neurons from rat embryo striatum were found to contain two structurally distinct forms of pp60c-src. The 60-kilodalton… 
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