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Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD.
The Ca2+-activated protein phosphatase calcineurin induces apoptosis, but the mechanism is unknown. Calcineurin was found to dephosphorylate BAD, a pro-apoptotic member of the Bcl-2 family, thusExpand
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Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4
A NEW facet of calcium signalling involves the nuclear import of the NF-AT transcription factors from their dormant position in the cytoplasm1–3. The protein phosphatase calcineurin appears to playExpand
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NFAT functions as a working memory of Ca2+ signals in decoding Ca2+ oscillation
Transcription by the nuclear factor of activated T cells (NFAT) is regulated by the frequency of Ca2+ oscillation. However, why and how Ca2+ oscillation regulates NFAT activity remain elusive. NFATExpand
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Intramolecular Masking of Nuclear Import Signal on NF-AT4 by Casein Kinase I and MEKK1
T cell activation requires the import of NF-AT transcription factors to the nucleus, a process promoted by calcineurin-dependent dephosphorylation and inhibited by poorly understood protein kinases.Expand
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Calcium Signal-induced Cofilin Dephosphorylation Is Mediated by Slingshot via Calcineurin*
Cofilin, an essential regulator of actin filament dynamics, is inactivated by phosphorylation at Ser-3 and reactivated by dephosphorylation. Although cofilin undergoes dephosphorylation in responseExpand
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Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2
It is not known how the protein Bcl-2 inhibits cell death induced by calcium signalling and growth-factor withdrawal1–3. Here we report that Bcl-2 forms a tight complex with calcineurin, resulting inExpand
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Histone Deacetylase 7 Associates with Hypoxia-inducible Factor 1α and Increases Transcriptional Activity*
Hypoxia-inducible factor (HIF)-1α is a transcription factor that controls expression of genes responsive to low oxygen tension, including vascular endothelial growth factor (VEGF), erythropoietin,Expand
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Calcineurin as a multifunctional regulator.
Long recognized as an important regulatory mechanism in biosignal processes, modulation of the phosphorylation state of proteins has emerged as the most important mechanism for understanding signalExpand
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Hypoxia and angiogenesis: regulation of hypoxia-inducible factors via novel binding factors
The mechanisms that regulate angiogenesis in hypoxia or hypoxic microenvironment are modulated by several pro- and antiangiogenic factors. Hypoxia-inducible factors (HIFs) have been established asExpand
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β-Adrenergic Pathway Induces Apoptosis through Calcineurin Activation in Cardiac Myocytes*
  • Shuichi Saito, Y. Hiroi, +6 authors I. Komuro
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 3 November 2000
Apoptosis of cardiac myocytes is one of the causes of heart failure. Here we examine the mechanism by which the activation of β-adrenergic receptor induces cardiomyocyte apoptosis. TerminalExpand
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