Lymphocyte Specific Protein Tyrosine Kinase p56(lck)

Known as: p56 lck, Protein c-lck, Proto-Oncogene, c-lck, Proto-Oncogene Protein 
This enzyme is a lymphoid-specific src family tyrosine kinase that is critical for T-cell development and activation. Lck is associated with the… (More)
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
T cell antigen receptor (TCR) and coreceptor ligation is thought to initiate signal transduction by inducing activation of the… (More)
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Highly Cited
2010
Highly Cited
2010
Calcium signaling is studied as a potential form of astrocyte excitability that may control astrocyte involvement in synaptic and… (More)
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2001
2001
Rheumatoid arthritis (RA) synovial fluid (SF)-T lymphocytes appear relatively inactive in situ and respond only weakly to diverse… (More)
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Highly Cited
1999
Highly Cited
1999
Ligation of the T cell antigen receptor (TCR) activates the Src family tyrosine kinase p56 Lck, which, in turn, phosphorylates a… (More)
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1998
1998
The lymphocyte-specific protein tyrosine kinase p56(lck) (Lck) is well documented with regard to its role in regulating T cell… (More)
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Highly Cited
1998
Highly Cited
1998
Recent data indicate that the cell surface glycoprotein CD5 functions as a negative regulator of T cell receptor (TCR)-mediated… (More)
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Highly Cited
1997
Highly Cited
1997
Galectin 3, a 30 kDa galactoside-binding protein distributed widely in epithelial and immune cells, contains no signal sequence… (More)
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Highly Cited
1996
Highly Cited
1996
REGULATION through phosphorylation is a characteristic of signalling pathways1,2, and the lymphocyte kinase Lck (p56 lck) both… (More)
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Highly Cited
1996
Highly Cited
1996
To determine if nitration of tyrosine residues by peroxynitrite (PN), which can be generated endogenously, can disrupt the… (More)
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1993
1993
Expression of the CD45 tyrosine protein phosphatase is required for the response of functional lymphocytes to stimulation through… (More)
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