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spirapril

Known as: 1,4-Dithia-7-azaspiro(4.4)nonane-8-carboxylic acid, 7-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)-, (8S-(7(R*(R*)),8R*))- 
A prodrug and non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Spirapril is converted in the body to its… 
National Institutes of Health

Related topics

Related topics

7 relations

Broader (3)

Angiotensin-Converting Enzyme InhibitorsAntihypertensive AgentsEnalapril

Narrower (3)

QuadroprilSCH 33844SPIRAPRIL HYDROCHLORIDE
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2013
Review
2013
Administration-Time Differences in Effects of Hypertension Medications on Ambulatory Blood Pressure Regulation
Specific features of the 24-h blood pressure (BP) pattern are linked to progressive injury of target tissues and risk of… 
Review
2011
Review
2011
Circadian rhythms in blood pressure regulation and optimization of hypertension treatment with ACE inhibitor and ARB medications.
Specific features of the 24 h-blood pressure (BP) pattern are linked to the progressive injury of target tissues and risk of… 
1998
1998
Little effect of ordinary antihypertensive therapy on nocturnal high blood pressure in patients with sleep disordered breathing.
1997
1997
Is endothelial function of the radial artery altered in human essential hypertension?
Highly Cited
1996
Highly Cited
1996
Antinociceptive effects of angiotensin-converting enzyme inhibitors and an angiotensin II receptor antagonist in mice.
Highly Cited
1995
Highly Cited
1995
Angiotensin-converting-enzyme inhibitors suppress synthesis of tumour necrosis factor and interleukin 1 by human peripheral blood mononuclear cells.
Administration of angiotensin-converting-enzyme (ACE) inhibitors reduce vascular proliferation following endothelial injury as… 
1993
1993
Spirapril Prevents Left Ventricular Hypertrophy, Decreases Myocardial Damage and Promotes Angiogenesis in Spontaneously Hypertensive Rats
To test whether angiotensin-converting enzyme (ACE) inhibition may prevent myocardial damage and may affect coronary… 
Highly Cited
1992
Highly Cited
1992
Partial escape of angiotensin converting enzyme (ACE) inhibition during prolonged ACE inhibitor treatment: does it exist and does it affect the antihypertensive response?
Objective To investigate whether the compensatory rise in renin and plasma angiotensin 1 in response to repeated angiotensin… 
Highly Cited
1991
Highly Cited
1991
PATHOGENETIC ROLE OF VASCULAR ANGIOTENSIN‐CONVERTING ENZYME IN THE SPONTANEOUSLY HYPERTENSIVE RAT
1. This study was undertaken to examine the possibility that the level of angiotensin‐converting enzyme (ACE) increases in… 
1989
1989
Angiotensin converting enzyme inhibitors: spirapril and related compounds.
The synthesis of spirapril (5), spiraprilat (25), their RSS stereoisomers, and their glycyl (18b) and lysyl (36, 37) analogues is… 
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