FAQ

spirapril

Known as: 1,4-Dithia-7-azaspiro(4.4)nonane-8-carboxylic acid, 7-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)-, (8S-(7(R*(R*)),8R*))- 
A prodrug and non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Spirapril is converted in the body to its… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1987-2016
051019872016

Related topics

Related topics

8 relations

Broader (3)

Angiotensin-Converting Enzyme InhibitorsAntihypertensive AgentsEnalapril

Narrower (3)

QuadroprilRenpressSCH 33844
SPIRAPRIL HYDROCHLORIDEanalogs & derivatives

Related mentions per year

Related mentions per year

1940-2018
19401960198020002020
spirapril
Angiotensin-Converting Enzyme Inhibitors
Antihypertensive Agents
Enalapril
Quadropril
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Administration-time-dependent effects of spirapril on ambulatory blood pressure in uncomplicated essential hypertension.
The administration of most angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) at bedtime… (More)
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1999
1999
Clinical experience with spirapril in human hypertension.
The efficacy and tolerability of spirapril were evaluated in a prospective, multicentre, post-marketing surveillance study on the… (More)
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1998
1998
Comparison of spirapril, isradipine, or combination in hypertensive patients with left ventricular hypertrophy: effects on LVH regression and arrhythmogenic propensity.
This study was designed to evaluate in 45 hypertensive patients with left ventricular hypertrophy (LVH) the effects of a 6-month… (More)
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1994
1994
Pharmacokinetics of spirapril in renal impairment.
The pharmacokinetics of spirapril and its active diacid metabolite spiraprilat were characterized in four groups of patients… (More)
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1994
1994
Spirapril: pharmacokinetic properties and drug interactions.
Spirapril is a prodrug that is converted by esterolysis to the active (but poorly absorbed) diacid spiraprilat. After intravenous… (More)
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1993
1993
Spirapril prevents left ventricular hypertrophy, decreases myocardial damage and promotes angiogenesis in spontaneously hypertensive rats.
To test whether angiotensin-converting enzyme (ACE) inhibition may prevent myocardial damage and may affect coronary… (More)
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1992
1992
Effect of spirapril on left ventricular hypertrophy due to volume overload in rats.
The effect of the angiotensin-converting enzyme (ACE) inhibitor spirapril on structural and functional parameters of volume… (More)
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1992
1992
Partial escape of angiotensin converting enzyme (ACE) inhibition during prolonged ACE inhibitor treatment: does it exist and does it affect the antihypertensive response?
OBJECTIVE To investigate whether the compensatory rise in renin and plasma angiotensin I in response to repeated angiotensin… (More)
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1991
1991
Converting enzyme inhibition after experimental myocardial infarction in rats: comparative study between spirapril and zofenopril.
STUDY OBJECTIVE The aim was to compare the effects of two novel angiotensin converting enzyme (ACE) inhibitors, spirapril and… (More)
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1989
1989
Angiotensin converting enzyme inhibitors: spirapril and related compounds.
The synthesis of spirapril (5), spiraprilat (25), their RSS stereoisomers, and their glycyl (18b) and lysyl (36, 37) analogues is… (More)
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