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spirapril
Known as:
1,4-Dithia-7-azaspiro(4.4)nonane-8-carboxylic acid, 7-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)-, (8S-(7(R*(R*)),8R*))-
A prodrug and non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Spirapril is converted in the body to its…
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National Institutes of Health
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Related topics
Related topics
7 relations
Broader (3)
Angiotensin-Converting Enzyme Inhibitors
Antihypertensive Agents
Enalapril
Narrower (3)
Quadropril
SCH 33844
SPIRAPRIL HYDROCHLORIDE
analogs & derivatives
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2013
Review
2013
Administration-Time Differences in Effects of Hypertension Medications on Ambulatory Blood Pressure Regulation
R. Hermida
,
D. Ayala
,
+4 authors
F. Portaluppi
Chronobiology International
2013
Corpus ID: 9313418
Specific features of the 24-h blood pressure (BP) pattern are linked to progressive injury of target tissues and risk of…
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Review
2011
Review
2011
Circadian rhythms in blood pressure regulation and optimization of hypertension treatment with ACE inhibitor and ARB medications.
R. Hermida
,
D. Ayala
,
J. Fernández
,
F. Portaluppi
,
F. Fabbian
,
M. Smolensky
American Journal of Hypertension
2011
Corpus ID: 40876077
Specific features of the 24 h-blood pressure (BP) pattern are linked to the progressive injury of target tissues and risk of…
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1998
1998
Little effect of ordinary antihypertensive therapy on nocturnal high blood pressure in patients with sleep disordered breathing.
L. Pelttari
,
E. Hietanen
,
T. Salo
,
M. Kataja
,
I. Kantola
American Journal of Hypertension
1998
Corpus ID: 38333643
1997
1997
Is endothelial function of the radial artery altered in human essential hypertension?
R. Schmieder
,
H. Weihprecht
,
+4 authors
R. Veelken
American Journal of Hypertension
1997
Corpus ID: 44719467
Highly Cited
1996
Highly Cited
1996
Antinociceptive effects of angiotensin-converting enzyme inhibitors and an angiotensin II receptor antagonist in mice.
S. Takai
,
K. Song
,
T. Tanaka
,
H. Okunishi
,
M. Miyazaki
Life Science
1996
Corpus ID: 31604308
Highly Cited
1995
Highly Cited
1995
Angiotensin-converting-enzyme inhibitors suppress synthesis of tumour necrosis factor and interleukin 1 by human peripheral blood mononuclear cells.
R. Schindler
,
C. Dinarello
,
K. Koch
Cytokine
1995
Corpus ID: 25836866
Administration of angiotensin-converting-enzyme (ACE) inhibitors reduce vascular proliferation following endothelial injury as…
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1993
1993
Spirapril Prevents Left Ventricular Hypertrophy, Decreases Myocardial Damage and Promotes Angiogenesis in Spontaneously Hypertensive Rats
G. Olivetti
,
E. Cigola
,
+4 authors
E. Ongini
Journal of Cardiovascular Pharmacology
1993
Corpus ID: 25671391
To test whether angiotensin-converting enzyme (ACE) inhibition may prevent myocardial damage and may affect coronary…
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Highly Cited
1992
Highly Cited
1992
Partial escape of angiotensin converting enzyme (ACE) inhibition during prolonged ACE inhibitor treatment: does it exist and does it affect the antihypertensive response?
A. H. van den Meiracker
,
A. J. Man in't veld
,
+4 authors
M. Schalekamp
Journal of Hypertension
1992
Corpus ID: 26840395
Objective To investigate whether the compensatory rise in renin and plasma angiotensin 1 in response to repeated angiotensin…
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Highly Cited
1991
Highly Cited
1991
PATHOGENETIC ROLE OF VASCULAR ANGIOTENSIN‐CONVERTING ENZYME IN THE SPONTANEOUSLY HYPERTENSIVE RAT
H. Okunishi
,
T. Kawamoto
,
+4 authors
M. Miyazaki
Clinical and Experimental Pharmacology and…
1991
Corpus ID: 29194659
1. This study was undertaken to examine the possibility that the level of angiotensin‐converting enzyme (ACE) increases in…
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1989
1989
Angiotensin converting enzyme inhibitors: spirapril and related compounds.
E. Smith
,
G. F. Swiss
,
+4 authors
T. Baum
Journal of Medicinal Chemistry
1989
Corpus ID: 45294152
The synthesis of spirapril (5), spiraprilat (25), their RSS stereoisomers, and their glycyl (18b) and lysyl (36, 37) analogues is…
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