spirapril

Known as: 1,4-Dithia-7-azaspiro(4.4)nonane-8-carboxylic acid, 7-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)-, (8S-(7(R*(R*)),8R*))- 
A prodrug and non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Spirapril is converted in the body to its… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1987-2016
051019872016

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
The administration of most angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) at bedtime… (More)
Is this relevant?
1999
1999
The efficacy and tolerability of spirapril were evaluated in a prospective, multicentre, post-marketing surveillance study on the… (More)
Is this relevant?
1998
1998
This study was designed to evaluate in 45 hypertensive patients with left ventricular hypertrophy (LVH) the effects of a 6-month… (More)
Is this relevant?
1994
1994
The pharmacokinetics of spirapril and its active diacid metabolite spiraprilat were characterized in four groups of patients… (More)
Is this relevant?
1994
1994
Spirapril is a prodrug that is converted by esterolysis to the active (but poorly absorbed) diacid spiraprilat. After intravenous… (More)
Is this relevant?
1993
1993
To test whether angiotensin-converting enzyme (ACE) inhibition may prevent myocardial damage and may affect coronary… (More)
Is this relevant?
1992
1992
The effect of the angiotensin-converting enzyme (ACE) inhibitor spirapril on structural and functional parameters of volume… (More)
Is this relevant?
1992
1992
OBJECTIVE To investigate whether the compensatory rise in renin and plasma angiotensin I in response to repeated angiotensin… (More)
Is this relevant?
1991
1991
STUDY OBJECTIVE The aim was to compare the effects of two novel angiotensin converting enzyme (ACE) inhibitors, spirapril and… (More)
Is this relevant?
1989
1989
The synthesis of spirapril (5), spiraprilat (25), their RSS stereoisomers, and their glycyl (18b) and lysyl (36, 37) analogues is… (More)
Is this relevant?