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spirapril

Known as: 1,4-Dithia-7-azaspiro(4.4)nonane-8-carboxylic acid, 7-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)-, (8S-(7(R*(R*)),8R*))- 
A prodrug and non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Spirapril is converted in the body to its… 
National Institutes of Health

Related topics

Related topics

7 relations

Broader (3)

Angiotensin-Converting Enzyme InhibitorsAntihypertensive AgentsEnalapril

Narrower (3)

QuadroprilSCH 33844SPIRAPRIL HYDROCHLORIDE
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2012
Review
2012
An Update of its Pharmacodynamic and Pharmacokinetic Properties and Therapeutic Efficacy in the Treatment of Mild to Moderate Hypertension
  • N.M.
  • 2012
  • Corpus ID: 261425211
Various sections of the manuscript reviewed by: N.D. Borhani, Carnelian Bay, California, USA; M. Epstein, Nephrology Section, VA… 
2007
2007
[A comparative analysis of normodipin and spirapril effects on intravascular activity of platelets in patients with metabolic syndrome].
AIM To study effects of two hypotensive drugs--normodipin and spirapril--on intravascular activity of platelets in patients with… 
2007
2007
A comparative analysis of normodipin and spirapril effects on intravascular activity of platelets in patients with metabolic syndrome
AIM To study effects of two hypotensive drugs--normodipin and spirapril--on intravascular activity of platelets in patients with… 
2006
2006
[Dynamics of prevalence of ischemic heart disease and risk of cardiovascular death in open population of Tiumen].
Prevalence of ischemic heart disease (IHD) has been repeatedly studied in 3 sex and age stratified representative samples of… 
2006
2006
[Rational approach to selection of antihypertensive therapy in persons with metabolic syndrome: efficacy of monotherapy with spirapril and its combination with retard form of nifedipine].
AIM: Achievement of target blood pressure (BP) levels in subjects with metabolic syndrome (MS) by the method of stepwise… 
1995
1995
Effects of Spirapril and Captopril on Regional Blood Flow in Chronic Congestive Heart Failure: A Comparison Between a Short- and a Long‐Acting Angiotensin‐Converting Enzyme Inhibitor
Spirapril is a new angiotensin-converting enzyme (ACE) inhibitor with a long duration of action. To determine whether duration of… 
1993
1993
Isradipine in the treatment of mild-to-moderate hypertension. The Austrian Multicenter Isradipine cum Spirapril Study (AMICUS).
The objective of this study was to assess the safety and efficacy of 1.25 to 2.5 mg of isradipine twice daily in patients with… 
1992
1992
Radioimmunoassays for Spirapril and Its Active Metabolite Spiraprilate: Performance and Application
Radioimmunoassays for a nonsulfhydryl angiotensin converting enzyme inhibitor prodrug–spirapril–and its active metabolite… 
1987
1987
Hemodynamic Effects of a New Angiotensin Converting Enzyme Inhibitor, Spirapril, in Sodium‐Loaded and Sodium‐Depleted Rabbits
Summary The new angiotensin converting enzyme inhibitor, spirapril, was found to inhibit the pressor effects of angiotensin I… 
1987
1987
Angiotensin converting enzyme inhibitory activity of SCH 33844 (spirapril) in rats, dogs and monkeys.
SCH 33844 is a new non-sulfhydryl-containing angiotensin converting enzyme (ACE) inhibitor. SCH 33844 diacid inhibited hydrolysis… 
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