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spirapril

Known as: 1,4-Dithia-7-azaspiro(4.4)nonane-8-carboxylic acid, 7-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)-, (8S-(7(R*(R*)),8R*))- 
A prodrug and non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Spirapril is converted in the body to its… Expand
National Institutes of Health

Related topics

Related topics

7 relations

Broader (3)

Angiotensin-Converting Enzyme InhibitorsAntihypertensive AgentsEnalapril

Narrower (3)

QuadroprilSCH 33844SPIRAPRIL HYDROCHLORIDE
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2013
Review
2013
Administration-Time Differences in Effects of Hypertension Medications on Ambulatory Blood Pressure Regulation
Specific features of the 24-h blood pressure (BP) pattern are linked to progressive injury of target tissues and risk of… Expand
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Review
2011
Review
2011
Circadian rhythms in blood pressure regulation and optimization of hypertension treatment with ACE inhibitor and ARB medications.
Specific features of the 24 h-blood pressure (BP) pattern are linked to the progressive injury of target tissues and risk of… Expand
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2010
2010
ADMINISTRATION-TIME-DEPENDENT EFFECTS OF SPIRAPRIL ON AMBULATORY BLOOD PRESSURE IN UNCOMPLICATED ESSENTIAL HYPERTENSION
The administration of most angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) at bedtime… Expand
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2007
2007
[A comparative analysis of normodipin and spirapril effects on intravascular activity of platelets in patients with metabolic syndrome].
AIM To study effects of two hypotensive drugs--normodipin and spirapril--on intravascular activity of platelets in patients with… Expand
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1998
1998
Comparison of spirapril, isradipine, or combination in hypertensive patients with left ventricular hypertrophy: effects on LVH regression and arrhythmogenic propensity.
This study was designed to evaluate in 45 hypertensive patients with left ventricular hypertrophy (LVH) the effects of a 6-month… Expand
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Highly Cited
1995
Highly Cited
1995
Angiotensin-converting-enzyme inhibitors suppress synthesis of tumour necrosis factor and interleukin 1 by human peripheral blood mononuclear cells.
Administration of angiotensin-converting-enzyme (ACE) inhibitors reduce vascular proliferation following endothelial injury as… Expand
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1993
1993
Spirapril prevents left ventricular hypertrophy, decreases myocardial damage and promotes angiogenesis in spontaneously hypertensive rats.
To test whether angiotensin-converting enzyme (ACE) inhibition may prevent myocardial damage and may affect coronary… Expand
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1993
1993
A comparison of spirapril and isradipine in patients with diabetic nephropathy and hypertension.
The effects of spirapril and isradipine on blood pressure, urinary albumin excretion and sodium-volume homeostasis in… Expand
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Highly Cited
1992
Highly Cited
1992
Partial escape of angiotensin converting enzyme (ACE) inhibition during prolonged ACE inhibitor treatment: does it exist and does it affect the antihypertensive response?
OBJECTIVE To investigate whether the compensatory rise in renin and plasma angiotensin I in response to repeated angiotensin… Expand
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1989
1989
Angiotensin converting enzyme inhibitors: spirapril and related compounds.
The synthesis of spirapril (5), spiraprilat (25), their RSS stereoisomers, and their glycyl (18b) and lysyl (36, 37) analogues is… Expand
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