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spirapril

Known as: 1,4-Dithia-7-azaspiro(4.4)nonane-8-carboxylic acid, 7-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)-, (8S-(7(R*(R*)),8R*))- 
A prodrug and non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Spirapril is converted in the body to its… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2013
Review
2013
Specific features of the 24-h blood pressure (BP) pattern are linked to progressive injury of target tissues and risk of… Expand
Review
2011
Review
2011
Specific features of the 24 h-blood pressure (BP) pattern are linked to the progressive injury of target tissues and risk of… Expand
2010
2010
The administration of most angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) at bedtime… Expand
2007
2007
  • I. Medvedev
  • Terapevticheskii arkhiv
  • 2007
  • Corpus ID: 36212017
AIM To study effects of two hypotensive drugs--normodipin and spirapril--on intravascular activity of platelets in patients with… Expand
1998
1998
This study was designed to evaluate in 45 hypertensive patients with left ventricular hypertrophy (LVH) the effects of a 6-month… Expand
Highly Cited
1995
Highly Cited
1995
Administration of angiotensin-converting-enzyme (ACE) inhibitors reduce vascular proliferation following endothelial injury as… Expand
1993
1993
To test whether angiotensin-converting enzyme (ACE) inhibition may prevent myocardial damage and may affect coronary… Expand
Highly Cited
1992
Highly Cited
1992
Objective To investigate whether the compensatory rise in renin and plasma angiotensin 1 in response to repeated angiotensin… Expand
Highly Cited
1991
Highly Cited
1991
1. This study was undertaken to examine the possibility that the level of angiotensin‐converting enzyme (ACE) increases in… Expand
1989
1989
The synthesis of spirapril (5), spiraprilat (25), their RSS stereoisomers, and their glycyl (18b) and lysyl (36, 37) analogues is… Expand