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spirapril

Known as: 1,4-Dithia-7-azaspiro(4.4)nonane-8-carboxylic acid, 7-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)-, (8S-(7(R*(R*)),8R*))- 
A prodrug and non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Spirapril is converted in the body to its… Expand
National Institutes of Health

Related topics

Related topics

7 relations

Broader (3)

Angiotensin-Converting Enzyme InhibitorsAntihypertensive AgentsEnalapril

Narrower (3)

QuadroprilSCH 33844SPIRAPRIL HYDROCHLORIDE
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2013
Review
2013
Administration-Time Differences in Effects of Hypertension Medications on Ambulatory Blood Pressure Regulation
Specific features of the 24-h blood pressure (BP) pattern are linked to progressive injury of target tissues and risk of… Expand
Review
2011
Review
2011
Circadian rhythms in blood pressure regulation and optimization of hypertension treatment with ACE inhibitor and ARB medications.
Specific features of the 24 h-blood pressure (BP) pattern are linked to the progressive injury of target tissues and risk of… Expand
2010
2010
ADMINISTRATION-TIME-DEPENDENT EFFECTS OF SPIRAPRIL ON AMBULATORY BLOOD PRESSURE IN UNCOMPLICATED ESSENTIAL HYPERTENSION
The administration of most angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) at bedtime… Expand
2007
2007
[A comparative analysis of normodipin and spirapril effects on intravascular activity of platelets in patients with metabolic syndrome].
  • I. Medvedev
  • Terapevticheskii arkhiv
  • 2007
    • Corpus ID: 36212017
AIM To study effects of two hypotensive drugs--normodipin and spirapril--on intravascular activity of platelets in patients with… Expand
1998
1998
Comparison of spirapril, isradipine, or combination in hypertensive patients with left ventricular hypertrophy: effects on LVH regression and arrhythmogenic propensity.
This study was designed to evaluate in 45 hypertensive patients with left ventricular hypertrophy (LVH) the effects of a 6-month… Expand
Highly Cited
1995
Highly Cited
1995
Angiotensin-converting-enzyme inhibitors suppress synthesis of tumour necrosis factor and interleukin 1 by human peripheral blood mononuclear cells.
Administration of angiotensin-converting-enzyme (ACE) inhibitors reduce vascular proliferation following endothelial injury as… Expand
1993
1993
Spirapril Prevents Left Ventricular Hypertrophy, Decreases Myocardial Damage and Promotes Angiogenesis in Spontaneously Hypertensive Rats
To test whether angiotensin-converting enzyme (ACE) inhibition may prevent myocardial damage and may affect coronary… Expand
Highly Cited
1992
Highly Cited
1992
Partial escape of angiotensin converting enzyme (ACE) inhibition during prolonged ACE inhibitor treatment: does it exist and does it affect the antihypertensive response?
Objective To investigate whether the compensatory rise in renin and plasma angiotensin 1 in response to repeated angiotensin… Expand
Highly Cited
1991
Highly Cited
1991
PATHOGENETIC ROLE OF VASCULAR ANGIOTENSIN‐CONVERTING ENZYME IN THE SPONTANEOUSLY HYPERTENSIVE RAT
1. This study was undertaken to examine the possibility that the level of angiotensin‐converting enzyme (ACE) increases in… Expand
1989
1989
Angiotensin converting enzyme inhibitors: spirapril and related compounds.
The synthesis of spirapril (5), spiraprilat (25), their RSS stereoisomers, and their glycyl (18b) and lysyl (36, 37) analogues is… Expand
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