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Topical ocular hypotensive effects of the novel angiotensin converting enzyme inhibitor SCH 33861 in conscious rabbits.
SCH 33861 is a novel, non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor. Topical administration of the compound to the eye of conscious rabbits was employed to examine actions on… Expand
Inhibition of efferent sympathetic nerve activity by 5-hydroxytryptophan and centrally administered 5-hydroxytryptamine
Abstract In view of the similarity of the cardiovascular actions of the 5-hydroxytryptamine precursor 5-hydroxytryptophan (5-HTP) and those of l -DOPA and the finding that l -DOPA reduces efferent… Expand
Antihypertensive and hemodynamic actions of SCH 19927, the R,R-isomer and labetalol.
- T. Baum, R. W. Watkins, +7 authors R. Moran
- Chemistry, Medicine
- The Journal of pharmacology and experimental…
- 1 August 1981
SCH 19927, one of the four chiral forms of labetalol, is approximately 4 times as potent as a beta adrenergic receptor blocker as the parent racemate, but is only one-third as potent in blocking… Expand
Hypotensive and postural effects of the gamma-aminobutyric acid agonist muscimol and of clonidine.
gamma-Aminobutyric acid (GABA) and GABA agonists, e.g., muscimol, have been shown to reduce blood pressure by a centrally mediated mechanism. The present series of experiments compared cardiovascular… Expand
Antihypertensive actions of an isomer of labetalol and other vasodilator-beta-adrenoceptor blockers.
Combinations of beta-adrenoceptor blockers and vasodilators have proved highly useful in antihypertensive therapy. Studies of the mechanisms of action of several agents that combine these effects… Expand
Pharmacology of labetalol in experimental animals.
Labetalol represents the culmination of an effort to enhance the antihypertensive efficacy and to improve the hemodynamic profile of beta-adrenoceptor blockers by incorporating an additional… Expand
Antihypertensive and orthostatic responses to drugs in conscious dogs.
- T. Baum, G. Vander Vliet, J. Glennon, P. Novak
- Journal of pharmacological methods
- 1 August 1981
In view of the frequent occurrence of orthostatic hypotension in antihypertensive therapy, the orthostatic potential of various classes of drugs was evaluated in conscious normotensive dogs in order… Expand
Observations on models used for the evaluation of antiarrhythmic drugs.
Elevation of ventricular fibrillatory threshold by beta-adrenergic blocking agents.
La conciliation des traitements médicamenteux des patients hospitalisés. Comprendre, s'initier et mettre en oeuvre la démarche dans un établissement de santé
La pratique de conciliation devrait etre inherente a toute prise en charge medicamenteuse du patient. Elle consiste a integrer a toute nouvelle prescription les traitements en cours du patient. Dans… Expand