spindle assembly checkpoint

Known as: Spindle Assembly Checkpoints, SAC, Checkpoint, Spindle Assembly 
A cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and chromosomes are attached to the… (More)
National Institutes of Health

Papers overview

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Review
2012
Review
2012
In eukaryotes, chromosome segregation during cell division is facilitated by the kinetochore, a multiprotein structure that is… (More)
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Highly Cited
2009
Highly Cited
2009
The spindle assembly checkpoint (SAC) monitors the attachment of microtubules to the kinetochore and inhibits anaphase when… (More)
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Highly Cited
2004
Highly Cited
2004
Paclitaxel stabilizes microtubules, causing mitotic arrest and activating the spindle assembly checkpoint. We determined whether… (More)
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Highly Cited
2003
Highly Cited
2003
The proper segregation of sister chromatids in mitosis depends on bipolar attachment of all chromosomes to the mitotic spindle… (More)
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Review
2002
Review
2002
Faithful transmission of chromosomes during mitosis is ensured by the spindle assembly checkpoint. This molecular safeguard… (More)
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Highly Cited
2002
Highly Cited
2002
Budding yeast Mps1p kinase has been implicated in both the duplication of microtubule-organizing centers and the spindle assembly… (More)
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Review
2000
Review
2000
arrest in mitosis following drug-induced inhibition of spindle microtubule assembly. These identified two trios of nonessential… (More)
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Review
1996
Review
1996
The spindle assembly checkpoint monitors proper chromosome attachment to spindle microtubules and is conserved from yeast to… (More)
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Highly Cited
1996
Highly Cited
1996
The spindle assembly checkpoint delays anaphase until all chromosomes are attached to a mitotic spindle. The mad (mitotic arrest… (More)
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Highly Cited
1996
Highly Cited
1996
The spindle assembly checkpoint keeps cells with defective spindles from initiating chromosome segregation. The protein kinase… (More)
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