spindle assembly checkpoint

Known as: Spindle Assembly Checkpoints, SAC, Checkpoint, Spindle Assembly 
A cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and chromosomes are attached to the… (More)
National Institutes of Health

Related topics

Related topics

4 relations

Broader (1)

M Phase Cell Cycle Checkpoints

Narrower (2)

meiotic spindle assembly checkpointmitotic spindle assembly checkpoint
spindle checkpoint activity

Papers overview

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Review
2012
Review
2012
Microtubule attachment and spindle assembly checkpoint signalling at the kinetochore
In eukaryotes, chromosome segregation during cell division is facilitated by the kinetochore, a multiprotein structure that is… (More)
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Highly Cited
2009
Highly Cited
2009
Kinetochore stretching inactivates the spindle assembly checkpoint
The spindle assembly checkpoint (SAC) monitors the attachment of microtubules to the kinetochore and inhibits anaphase when… (More)
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Highly Cited
2004
Highly Cited
2004
Dependence of paclitaxel sensitivity on a functional spindle assembly checkpoint.
Paclitaxel stabilizes microtubules, causing mitotic arrest and activating the spindle assembly checkpoint. We determined whether… (More)
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Highly Cited
2003
Highly Cited
2003
The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore–microtubule attachment and in maintaining the spindle assembly checkpoint
The proper segregation of sister chromatids in mitosis depends on bipolar attachment of all chromosomes to the mitotic spindle… (More)
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Review
2002
Review
2002
Attachment and tension in the spindle assembly checkpoint.
Faithful transmission of chromosomes during mitosis is ensured by the spindle assembly checkpoint. This molecular safeguard… (More)
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Highly Cited
2002
Highly Cited
2002
Human Mps1 kinase is required for the spindle assembly checkpoint but not for centrosome duplication.
Budding yeast Mps1p kinase has been implicated in both the duplication of microtubule-organizing centers and the spindle assembly… (More)
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Review
2000
Review
2000
Waiting for Anaphase Mad2 and the Spindle Assembly Checkpoint
arrest in mitosis following drug-induced inhibition of spindle microtubule assembly. These identified two trios of nonessential… (More)
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Review
1996
Review
1996
The spindle assembly checkpoint.
The spindle assembly checkpoint monitors proper chromosome attachment to spindle microtubules and is conserved from yeast to… (More)
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Highly Cited
1996
Highly Cited
1996
Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores.
The spindle assembly checkpoint delays anaphase until all chromosomes are attached to a mitotic spindle. The mad (mitotic arrest… (More)
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Highly Cited
1996
Highly Cited
1996
Activation of the budding yeast spindle assembly checkpoint without mitotic spindle disruption.
The spindle assembly checkpoint keeps cells with defective spindles from initiating chromosome segregation. The protein kinase… (More)
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