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mitotic spindle assembly checkpoint

Known as: mitotic cell cycle spindle assembly checkpoint 
A cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and… 
National Institutes of Health

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Broader (2)

Mitotic Cell Cyclespindle assembly checkpoint
negative regulation of mitotic spindle assembly checkpoint

Papers overview

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2020
2020
BuGZ facilitates loading of spindle assembly checkpoint proteins to kinetochores in early mitosis
BuGZ is a kinetochore component that binds to and stabilizes Bub3, a key player in mitotic spindle assembly checkpoint signaling… 
2015
2015
Mad2 Inhibitor-1 (M2I-1): A Small Molecule Protein-Protein Interaction Inhibitor Targeting the Mitotic Spindle Assembly Checkpoint.
The genetic integrity of each organism depends on the faithful segregation of its genome during mitosis. To meet this challenge… 
Highly Cited
2013
Highly Cited
2013
Kinetic framework of spindle assembly checkpoint signalling
The mitotic spindle assembly checkpoint (SAC) delays anaphase onset until all chromosomes have attached to both spindle poles… 
2013
2013
The MAD1 1673 G→A polymorphism alters the function of the mitotic spindle assembly checkpoint and is associated with a worse response to induction chemotherapy and sensitivity to treatment in…
Background Mitotic arrest deficient 1 (MAD1), a protein of the mitotic spindle assembly checkpoint (SAC), recognizes MAD2 through… 
2012
2012
Spatial and temporal organization of multi-protein assemblies: achieving sensitive control in information-rich cell-regulatory systems
The regulation of cellular processes in living organisms requires signalling systems that have a high signal-to-noise ratio. This… 
2008
2008
Loss of CHFR in human mammary epithelial cells causes genomic instability by disrupting the mitotic spindle assembly checkpoint.
CHFR is an E3 ubiquitin ligase and an early mitotic checkpoint protein implicated in many cancers and in the maintenance of… 
2008
2008
Overexpression of the mitotic spindle assembly checkpoint genes hBUB1, hBUBR1 and hMAD2 in thyroid carcinomas with aggressive nature.
BACKGROUND The mitotic spindle assembly checkpoint (MSAC) genes are responsible for preventing chromosome missegregation. MSAC… 
2007
2007
2-methoxyestradiol inhibits the anaphase-promoting complex and protein translation in human breast cancer cells.
2-methoxyestradiol (2ME2), an estradiol metabolite with antiproliferative and antiangiogenic activities, is in phase I/II… 
Highly Cited
2006
Highly Cited
2006
Spindle checkpoint function requires Mad2-dependent Cdc20 binding to the Mad3 homology domain of BubR1.
2002
2002
Expression of mitotic spindle checkpoint protein hsMAD1 correlates with cellular proliferation and is activated by a gain-of-function p53 mutant.
Human mitotic arrest deficiency protein 1, hsMAD1, is a component of the mitotic spindle assembly checkpoint (MSC) that monitors… 
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