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Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2
Mitotic kinases of the Polo and Aurora families are key regulators of chromosome segregation and cytokinesis. Here, we have investigated the role of MKlp1 and MKlp2, two vertebrate mitotic kinesinsExpand
Nud1p links astral microtubule organization and the control of exit from mitosis
The budding yeast spindle pole body (SPB) not only organizes the astral and nuclear microtubules but is also associated with a number of cell‐cycle regulators that control mitotic exit. Here, weExpand
Choice of Plk1 docking partners during mitosis and cytokinesis is controlled by the activation state of Cdk1
Spatial and temporal coordination of polo-like kinase 1 (Plk1) activity is necessary for mitosis and cytokinesis, and this is achieved through binding to phosphorylated docking proteins with distinctExpand
Centromere targeting of the chromosomal passenger complex requires a ternary subcomplex of Borealin, Survivin, and the N-terminal domain of INCENP.
The chromosomal passenger complex (CPC), consisting of the serine/threonine kinase Aurora B, the inner centromere protein INCENP, Survivin, and Borealin/DasraB, has essential functions at theExpand
Cytokinesis: Placing and Making the Final Cut
Cytokinesis is the process by which cells physically separate after the duplication and spatial segregation of the genetic material. A number of general principles apply to this process. First theExpand
KIF14 and citron kinase act together to promote efficient cytokinesis
Multiple mitotic kinesins and microtubule-associated proteins (MAPs) act in concert to direct cytokinesis (Glotzer, M. 2005. Science. 307:1735–1739). In anaphase cells, many of these proteinsExpand
Astrin is required for the maintenance of sister chromatid cohesion and centrosome integrity
Faithful chromosome segregation in mitosis requires the formation of a bipolar mitotic spindle with stably attached chromosomes. Once all of the chromosomes are aligned, the connection between theExpand
PP2A-B56 opposes Mps1 phosphorylation of Knl1 and thereby promotes spindle assembly checkpoint silencing
The kinetochore surveillance phosphatase PP2A-B56 dephosphorylates Knl1 to silence the spindle assembly checkpoint after all chromosomes have been correctly attached to microtubules.
Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2
Loss of PP6 function interferes with spindle formation and chromosome alignment because of amplified Aurora A activity.
The astrin–kinastrin/SKAP complex localizes to microtubule plus ends and facilitates chromosome alignment
Kinastrin is identified as a major interacting partner for astrin in mitotic cells, and is required for astrin targeting to microtubule plus ends.