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Choice of Plk1 docking partners during mitosis and cytokinesis is controlled by the activation state of Cdk1
It is shown that the microtubule-associated protein regulating cytokinesis (PRC1) is an anaphase-specific binding partner for Plk1, and that this interaction is required for cytokinesIS.
Centromere targeting of the chromosomal passenger complex requires a ternary subcomplex of Borealin, Survivin, and the N-terminal domain of INCENP.
It is demonstrated that CPC targeting to the centromere does not depend on CENP-A and hMis12, two core components for kinetochore/centromere assembly, and evidence that the CPC may be directed to centromeric DNA directly via the Borealin subunit is provided.
Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2
It is proposed that MKlp2 is involved in the localization of Plk1, Aurora B, and Cdc14A to the central spindle during anaphase, and that the integration of signaling by these proteins is necessary for proper cytokinesis.
Nud1p links astral microtubule organization and the control of exit from mitosis
- U. Gruneberg, K. Campbell, Clare E. Simpson, J. Grindlay, E. Schiebel
- BiologyThe EMBO journal
- 1 December 2000
It is described that the core SPB component Nud1p is a key protein that functions in both budding yeast spindle pole body and mitotic exit, and the failure of Tem1p to interact with Cdc15p at the SPB probably prevents mitoticExit.
Cytokinesis: Placing and Making the Final Cut
Astrin is required for the maintenance of sister chromatid cohesion and centrosome integrity
Departure of the microtubule and kinetochore protein astrin results in checkpoint-arrested cells with multipolar spindles and separated sister chromatids, which is consistent with untimely separase activation, and it is suggested that a strin contributes to the regulatory network that controls separase activity.
KIF14 and citron kinase act together to promote efficient cytokinesis
It is found that KIF14 targets to the central spindle via its interaction with PRC1 and has an essential function in cytokinesis and a general requirement for citron kinase in human cell division is found.
PP2A-B56 opposes Mps1 phosphorylation of Knl1 and thereby promotes spindle assembly checkpoint silencing
- A. Espert, Pelin Uluocak, R. Bastos, Davinderpreet Mangat, P. Graab, U. Gruneberg
- BiologyThe Journal of cell biology
- 29 September 2014
The kinetochore surveillance phosphatase PP2A-B56 dephosphorylates Knl1 to silence the spindle assembly checkpoint after all chromosomes have been correctly attached to microtubules.
The BEG (PP2A-B55/ENSA/Greatwall) Pathway Ensures Cytokinesis follows Chromosome Separation
The astrin–kinastrin/SKAP complex localizes to microtubule plus ends and facilitates chromosome alignment
- A. Dunsch, E. Linnane, F. Barr, U. Gruneberg
- Biology, PhysicsThe Journal of cell biology
- 21 March 2011
Kinastrin is identified as a major interacting partner for astrin in mitotic cells, and is required for astrin targeting to microtubule plus ends.