spindle checkpoint activity

Known as: spindle checkpoint 
A cell cycle checkpoint that originates from the mitotic or meiotic spindle. [GOC:mtg_cell_cycle]
National Institutes of Health

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Review
2005
Review
2005
The spindle checkpoint ensures the fidelity of chromosome segregation by preventing cell-cycle progression until all the… (More)
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Highly Cited
2004
Highly Cited
2004
BACKGROUND To test current models for how unattached and untense kinetochores prevent Cdc20 activation of the anaphase-promoting… (More)
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Highly Cited
2003
Highly Cited
2003
We show that the Xenopus homologs of Ndc80/Tid3/HEC1 (xNdc80) and Nuf2/MPP1/Him-10 (xNuf2) proteins physically interact in a 190… (More)
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Highly Cited
2002
Highly Cited
2002
The E2F transcription factor family is known to play a key role in the timely expression of genes required for cell cycle… (More)
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Highly Cited
2002
Highly Cited
2002
The spindle checkpoint delays sister chromatid separation until all chromosomes have undergone bipolar spindle attachment… (More)
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Highly Cited
2001
Highly Cited
2001
We discovered that many proteins located in the kinetochore outer domain, but not the inner core, are depleted from kinetochores… (More)
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Highly Cited
2001
Highly Cited
2001
The spindle checkpoint prevents cell cycle progression in cells that have mitotic spindle defects. Although several spindle… (More)
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Review
1999
Review
1999
Prior to sister-chromatid separation, the spindle checkpoint inhibits cell-cycle progression in response to a signal generated by… (More)
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Highly Cited
1998
Highly Cited
1998
The spindle checkpoint regulates the cell division cycle by keeping cells with defective spindles from leaving mitosis. In the… (More)
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Highly Cited
1995
Highly Cited
1995
p21CIP1/WAF1 is a CDK inhibitor regulated by the tumor suppressor p53 and is hypothesized to mediate G1 arrest. p53 has been… (More)
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