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spindle checkpoint activity
Known as:
spindle checkpoint
A cell cycle checkpoint that originates from the mitotic or meiotic spindle. [GOC:mtg_cell_cycle]
National Institutes of Health
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Mitotic Spindle Checkpoints
meiotic spindle checkpoint
regulation of spindle checkpoint
spindle assembly checkpoint
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Escape from Mitotic Arrest: An Unexpected Connection Between Microtubule Dynamics and Epigenetic Regulation of Centromeric Chromatin in Schizosaccharomyces pombe
Anuja A George
,
N. Walworth
Genetics
2015
Corpus ID: 24178130
Accurate chromosome segregation is necessary to ensure genomic integrity. Segregation depends on the proper functioning of the…
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2010
2010
Effect of Mad 2 on Paclitaxel-induced Cell Death in Ovarian Cancer Cells
Zhigang Zhou
,
Shuangmei Ye
,
Shixuan Wang
2010
Corpus ID: 13191683
In this article, the status of spindle assembly checkpoint and the alteration of its major component, Mad2 protein level were…
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2008
2008
Regulation of Kinetochore Recruitment of Two Essential Mitotic Spindle Checkpoint Proteins by Mps 1 Phosphorylation
El
,
Idsimnk
,
+11 authors
Pnsilk
2008
Corpus ID: 29281486
Mps1 is a protein kinase that plays essential roles in spindle checkpoint signaling. Unattached kinetochores or lack of tension…
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2007
2007
p 53 Activation in Response to Mitotic Spindle Damage Requires Signaling via BubR 1-Mediated Phosphorylation
Geun‐Hyoung Ha
,
Kwan-Hyuck Baek
,
+4 authors
Chang-Woo Lee
2007
Corpus ID: 8175923
The mitotic spindle checkpoint plays a crucial role in regulating accurate chromosome segregation and preventing the adaptation…
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2006
2006
Bub 1 Up-Regulation and Hyperphosphorylation Promote Malignant Transformation in SV 40 Tag – Induced Transgenic Mouse Models
Conghui Guo
,
Guojun Wu
,
+6 authors
J. Xuan
2006
Corpus ID: 8116159
Rodents do not naturally develop prostate cancer. Currently, most widely used genetically engineered mouse prostate cancer models…
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Review
2004
Review
2004
Apoptosis by p53: mechanisms, regulation, and clinical implications
Ronit Vogt Sionov
,
Y. Haupt
Springer Seminars in Immunopathology
2004
Corpus ID: 8122022
A loss of p53 tumor suppressor function is the most common event leading to the development of cancer. Genetic alterations in p53…
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2004
2004
Mammary Epithelium Hormone-Induced Chromosomal Instability in p 53-Null Updated
D. Pati
,
B. Haddad
,
+10 authors
D. Medina
2004
Corpus ID: 53376991
The absence of p53 function increases risk for spontaneous tumorigenesis in the mammary gland. Hormonal stimulation enhances…
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2003
2003
PREMATURE CENTROMERE DIVISION AS A BIOMARKER OF GENOTOXIC INFLUENCES
S. Rushkovsky
,
Y. Petrenko
,
V. Bezrukov
2003
Corpus ID: 51813798
The analysis of spontaneous and UV-induced premature centromere division (PCD) in the peripheral blood lymphocytes of humans was…
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2003
2003
BUBR 1-deficiency Results In Abnormal
Megakaryopoiesis Qi Wang
,
Tongyi Liu
,
+8 authors
W. Dai
2003
Corpus ID: 8305729
The physiological function of BUBR1, a key component of the spindle checkpoint, was examined by the generation of BUBR1 mutant…
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1999
1999
p 53 regulates a G 2 checkpoint through cyclin B 1 ( cell cycle y cdc 2 y mitosis y cancer )
Steven
,
A.
,
+8 authors
Lee
1999
Corpus ID: 32267347
The p53 tumor suppressor controls multiple cell cycle checkpoints regulating the mammalian response to DNA damage. To identify…
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