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Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5
TLDR
It is demonstrated that the induction of type I interferon by viruses deficient in 2′-O-methyltransferase was dependent on the cytoplasmic RNA sensor Mda5, which suggests that RNA modifications such as 2-methylation provide a molecular signature for the discrimination of self and non-self mRNA. Expand
Structure of coronavirus main proteinase reveals combination of a chymotrypsin fold with an extra α-helical domain
TLDR
The crystal structure of the 33.1 kDa transmissible gastroenteritis (corona)virus Mpro is reported and illustrates that RNA viruses have evolved unprecedented variations of the classical chymotrypsin fold. Expand
A Contemporary View of Coronavirus Transcription
TLDR
The hallmark of coronavirus transcription is the production of multiple subgenomic mRNAs that contain sequences corresponding to both ends of the genome. Expand
Infectious RNA transcribed in vitro from a cDNA copy of the human coronavirus genome cloned in vaccinia virus.
TLDR
A reverse-genetic system is described for the generation of recombinant coronaviruses based upon the in vitro transcription of infectious RNA from a cDNA copy of the human coronavirus 229E genome that has been cloned and propagated in vaccinia virus. Expand
Changes to taxonomy and the International Code of Virus Classification and Nomenclature ratified by the International Committee on Taxonomy of Viruses (2017)
This article lists the changes to virus taxonomy approved and ratified by the International Committee on Taxonomy of Viruses (ICTV) in March 2017.
Virus taxonomy: the database of the International Committee on Taxonomy of Viruses (ICTV)
TLDR
This Report provides a comprehensive description of all virus taxa covering virus structure, genome structure, biology and phylogenetics, and is replacing the previous hard-copy edition with a completely open access, continuously updated publication. Expand
The nsp9 Replicase Protein of SARS-Coronavirus, Structure and Functional Insights
TLDR
It is shown that nsp9 binds RNA and interacts with nsp8, activities that may be essential for its function(s), and the crystal structure suggests that the protein is dimeric. Expand
Ratification vote on taxonomic proposals to the International Committee on Taxonomy of Viruses (2016)
This article lists the changes to virus taxonomy approved and ratified by the International Committee on Taxonomy of Viruses (ICTV) in April 2016.Changes to virus taxonomy (the Universal Scheme ofExpand
Changes to taxonomy and the International Code of Virus Classification and Nomenclature ratified by the International Committee on Taxonomy of Viruses (2018)
This article lists the changes to virus taxonomy approved and ratified by the International Committee on Taxonomy of Viruses in February 2018. A total of 451 species, 69 genera, 11 subfamilies, 9Expand
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