sphingomyelin phosphodiesterase activity

Known as: sphingomyelin cholinephosphohydrolase activity, sphingomyelinase activity 
Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+). [EC:3.1.4.12, RHEA:19256]
National Institutes of Health

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SPHINGOMYELINASEacid sphingomyelinase

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acid sphingomyelin phosphodiesterase activity

Papers overview

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2009
2009
Staphylococcus aureus beta-toxin induces lung injury through syndecan-1.
In pneumonia caused by the bacterium Staphylococcus aureus, the intense inflammatory response that is triggered by this infection… (More)
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Highly Cited
2007
Highly Cited
2007
Increased skeletal muscle ceramide level in men at risk of developing type 2 diabetes
Intramyocellular lipids, including ceramide, a second messenger in the sphingomyelin signalling pathway, might contribute to the… (More)
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Highly Cited
2004
Highly Cited
2004
Impaired sphingomyelinase activity and epidermal differentiation in atopic dermatitis.
A defective permeability barrier leads to the penetration of environmental allergens into the skin and initiates immunological… (More)
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Highly Cited
2000
Highly Cited
2000
Rapid activation of neutral sphingomyelinase by hypoxia-reoxygenation of cardiac myocytes.
Elevated levels of oxygen free radicals have been implicated in the pathways of reperfusion injury to myocardial tissue. The… (More)
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1998
1998
Restoration of TNF-alpha-induced ceramide generation and apoptosis in resistant human leukemia KG1a cells by the P-glycoprotein blocker PSC833.
Tumor necrosis factor (TNF-alpha) is a cytokine with antitumor activity against several cellular models. TNF-alpha-induced… (More)
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Highly Cited
1996
Highly Cited
1996
Acid Sphingomyelinase–Deficient Human Lymphoblasts and Mice Are Defective in Radiation-Induced Apoptosis
Stress is believed to activate sphingomyelinase to generate ceramide, which serves as a second messenger in initiating the… (More)
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Highly Cited
1995
Highly Cited
1995
Differential regulation of sphingomyelinase and ceramidase activities by growth factors and cytokines. Implications for cellular proliferation and differentiation.
Sphingosine is a product of sphingolipid metabolism that has been linked to a protein kinase C-independent mitogenic response. In… (More)
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Highly Cited
1991
Highly Cited
1991
Purification and characterization of an extracellular 29-kilodalton phospholipase C from Listeria monocytogenes.
We purified and characterized an extracellular phospholipase produced by Listeria monocytogenes. This enzyme was separated as a… (More)
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Highly Cited
1990
Highly Cited
1990
Sphingomyelin synthesis in rat liver occurs predominantly at the cis and medial cisternae of the Golgi apparatus.
The intracellular site of sphingomyelin (SM) synthesis was examined in subcellular fractions from rat liver using a radioactive… (More)
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Review
1989
Review
1989
Sphingolipid activator protein deficiency in a 16-week-old atypical Gaucher disease patient and his fetal sibling: Biochemical signs of combined sphingolipidoses
We describe a patient who presented shortly after birth with hyperkinetic behaviour, myoclonia, respiratory insufficiency and… (More)
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