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sphingomyelin phosphodiesterase activity

Known as: sphingomyelin cholinephosphohydrolase activity, sphingomyelinase activity 
Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+). [EC:3.1.4.12, RHEA:19256]
National Institutes of Health

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SPHINGOMYELINASEacid sphingomyelinase

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acid sphingomyelin phosphodiesterase activity

Papers overview

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Review
2004
Review
2004
Molecular Mechanisms of Fenretinide‐Induced Apoptosis of Neuroblastoma Cells
Abstract: Synthetic retinoids such as fenretinide [N‐(4‐hydroxyphenyl)retinamide] induce apoptosis of neuroblastoma cells, act… 
Highly Cited
2003
Highly Cited
2003
Ceramide in rafts (detergent‐insoluble fraction) mediates cell death in neurotumor cell lines
Detergent‐resistant lipid microdomains (Rafts) were isolated from human oligodendroglioma (HOG), human neuroblastoma (LA‐N‐5… 
2000
2000
Coenzyme Q protects cells against serum withdrawal-induced apoptosis by inhibition of ceramide release and caspase-3 activation.
Coenzyme Q10 (CoQ10) is a component of the antioxidant machinery that protects cell membranes from oxidative damage and decreases… 
1997
1997
Myelin contains neutral sphingomyelinase activity that is stimulated by tumor necrosis factor‐α
Purified myelin from mouse brain was found to contain two forms of neutral sphingomyelinase, one Mg2+ dependent and the other Mg2… 
Highly Cited
1995
Highly Cited
1995
Alkaline sphingomyelinase activity in rat gastrointestinal tract: distribution and characteristics.
Highly Cited
1991
Highly Cited
1991
Reversal of multidrug resistance by calcium channel blocker SR33557 without photoaffinity labeling of P-glycoprotein.
1990
1990
Very low levels of high density lipoprotein cholesterol in four sibs of a family with non-neuropathic Niemann-Pick disease and sea-blue histiocytosis.
Very low serum levels of high density lipoprotein cholesterol ranging from 8.6 to 13.9 mg/dl were detected in four out of 12 sibs… 
1987
1987
Effects of gentamicin on sphingomyelinase activity in cultured human renal proximal tubular cells.
Highly Cited
1982
Highly Cited
1982
In situ degradation of sphingomyelin by cultured normal fibroblasts and fibroblasts from patients with Niemann-Pick disease type A and C.
1967
1967
Phospholipases in arterial tissue. I. Sphingomyelin cholinephosphohydrolase activity in human, dog, guinea pig, rat and rabbit arteries.
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