sphingomyelin phosphodiesterase activity

Known as: sphingomyelin cholinephosphohydrolase activity, sphingomyelinase activity 
Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+). [EC:3.1.4.12, RHEA:19256]
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
In pneumonia caused by the bacterium Staphylococcus aureus, the intense inflammatory response that is triggered by this infection… (More)
Is this relevant?
Highly Cited
2007
Highly Cited
2007
Intramyocellular lipids, including ceramide, a second messenger in the sphingomyelin signalling pathway, might contribute to the… (More)
  • figure 1
  • table 1
  • figure 2
  • table 2
  • figure 3
Is this relevant?
Highly Cited
2004
Highly Cited
2004
A defective permeability barrier leads to the penetration of environmental allergens into the skin and initiates immunological… (More)
Is this relevant?
Highly Cited
2000
Highly Cited
2000
Elevated levels of oxygen free radicals have been implicated in the pathways of reperfusion injury to myocardial tissue. The… (More)
Is this relevant?
1998
1998
Tumor necrosis factor (TNF-alpha) is a cytokine with antitumor activity against several cellular models. TNF-alpha-induced… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1996
Highly Cited
1996
Stress is believed to activate sphingomyelinase to generate ceramide, which serves as a second messenger in initiating the… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1995
Highly Cited
1995
Sphingosine is a product of sphingolipid metabolism that has been linked to a protein kinase C-independent mitogenic response. In… (More)
Is this relevant?
Highly Cited
1991
Highly Cited
1991
We purified and characterized an extracellular phospholipase produced by Listeria monocytogenes. This enzyme was separated as a… (More)
  • figure 1
  • figure 2
  • table 1
  • figure 4
  • figure 3
Is this relevant?
Highly Cited
1990
Highly Cited
1990
The intracellular site of sphingomyelin (SM) synthesis was examined in subcellular fractions from rat liver using a radioactive… (More)
Is this relevant?
Review
1989
Review
1989
We describe a patient who presented shortly after birth with hyperkinetic behaviour, myoclonia, respiratory insufficiency and… (More)
  • figure 1
  • table 1
  • table 2
  • table 3
  • figure 2
Is this relevant?