acid sphingomyelin phosphodiesterase activity

Known as: acid sphingomyelinase 
Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+) in an acidic environment. [GOC:dph, PMID:26493087]
National Institutes of Health

Topic mentions per year

Topic mentions per year

1981-2017
051019812017

Papers overview

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2010
2010
The present study tested a hypothesis that excess accumulation of sphingolipid, ceramide, its metabolites, or a combination… (More)
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2009
2009
Acid sphingomyelinase plays important roles in ceramide homeostasis, which has been proposed to be linked to insulin resistance… (More)
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2008
2008
Obesity increases the risk for metabolic and cardiovascular disease, and adipose tissue plays a central role in this process… (More)
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2008
2008
RATIONALE In acute inflammatory lung disease in newborn infants, exogenous surfactant only transiently improves lung function. We… (More)
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2007
2007
Ceramide has been shown by many studies to induce apoptosis. Therefore, upregulation of ceramide is discussed as a novel approach… (More)
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2005
2005
In this report, we show for the first time that ceramide-1-phosphate (C1P) stimulates the phosphatidylinositol 3-kinase (PI3-K… (More)
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2003
2003
Macrophages play a central role in the development and progression of atherosclerotic lesions. It is well known that oxidized low… (More)
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2002
2002
Activation of acid and neutral sphingomyelinases, and the ensuing generation of ceramide, contributes to the biological effects… (More)
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Highly Cited
1996
Highly Cited
1996
Stress is believed to activate sphingomyelinase to generate ceramide, which serves as a second messenger in initiating the… (More)
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1985
1985
AY-9944 (trans-1,4-bis(2-chlorobenzylaminoethyl)cyclohexane dihydrochloride), a cationic amphiphilic drug, caused a rapid… (More)
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