SPHINGOMYELINASE

Known as: SMPD1, Sphingomyelinase C, Acid Sphingomyelinase 
An enzyme that catalyzes the hydrolysis of sphingomyelin to ceramide (N-acylsphingosine) plus choline phosphate. A defect in this enzyme leads to… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1956-2017
05010015019562016

Papers overview

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Highly Cited
2012
Highly Cited
2012
Eryptosis, the suicidal erythrocyte death, leads to cell shrinkage and cell membrane scrambling with phosphatidylserine exposure… (More)
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Highly Cited
2010
Highly Cited
2010
The existence of circulating microRNAs (miRNAs) in the blood of cancer patients has raised the possibility that miRNAs may serve… (More)
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Highly Cited
2009
Highly Cited
2009
We have earlier shown that microglia, the immune cells of the CNS, release microparticles from cell plasma membrane after ATP… (More)
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Highly Cited
2007
Highly Cited
2007
Wilson disease is caused by accumulation of Cu2+ in cells, which results in liver cirrhosis and, occasionally, anemia. Here, we… (More)
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Highly Cited
2005
Highly Cited
2005
Recent evidence suggests clustering of plasma membrane rafts into ceramide-enriched platforms serves as a transmembrane signaling… (More)
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Highly Cited
2000
Highly Cited
2000
The time at which ovarian failure (menopause) occurs in females is determined by the size of the oocyte reserve provided at birth… (More)
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Highly Cited
1998
Highly Cited
1998
ATP hydrolysis has been regarded as a general requirement for internalization processes in mammalian cells. We found, however… (More)
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Highly Cited
1998
Highly Cited
1998
Sphingomyelin is an abundant constituent of the plasma membranes of mammalian cells. Ceramide, its primary catabolic intermediate… (More)
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Highly Cited
1997
Highly Cited
1997
Invasion of human mucosal cells by N. gonorrhoeae via the binding to heparansulfate proteoglycan receptors is considered a… (More)
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Highly Cited
1996
Highly Cited
1996
Stress is believed to activate sphingomyelinase to generate ceramide, which serves as a second messenger in initiating the… (More)
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