Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

SPHINGOMYELINASE

Known as: SMPD1, Sphingomyelinase C, Acid Sphingomyelinase 
An enzyme that catalyzes the hydrolysis of sphingomyelin to ceramide (N-acylsphingosine) plus choline phosphate. A defect in this enzyme leads to… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Lysosomal enzyme acid sphingomyelinase is released extracellularly when cells are wounded, converting sphingomyelin to ceramide… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2009
Highly Cited
2009
We have earlier shown that microglia, the immune cells of the CNS, release microparticles from cell plasma membrane after ATP… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2007
Highly Cited
2007
Wilson disease is caused by accumulation of Cu2+ in cells, which results in liver cirrhosis and, occasionally, anemia. Here, we… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Platelet-activating factor (PAF) induces pulmonary edema and has a key role in acute lung injury (ALI). Here we show that PAF… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2004
Highly Cited
2004
AbstractAcidic noncaspase proteases-like cathepsins have been introduced as novel mediators of apoptosis. A clear role for these… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2004
Highly Cited
2004
A defective permeability barrier leads to the penetration of environmental allergens into the skin and initiates immunological… Expand
Is this relevant?
Highly Cited
2000
Highly Cited
2000
The time at which ovarian failure (menopause) occurs in females is determined by the size of the oocyte reserve provided at birth… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1996
Highly Cited
1996
Stress is believed to activate sphingomyelinase to generate ceramide, which serves as a second messenger in initiating the… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1996
Highly Cited
1996
Tumor necrosis factor (TNF)-α plays a central role in the state of insulin resistance associated with obesity. It has previously… Expand
  • figure 1
  • figure 4
  • figure 2
  • figure 3
  • figure 5
Is this relevant?
Highly Cited
1995
Highly Cited
1995
Types A and B Niemann–Pick disease (NPD) result from the deficient activity of acid sphingomyelinase (ASM). An animal model of… Expand
Is this relevant?