• Publications
  • Influence
Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus-induced demyelinating disease. V. Mapping of a dominant immunopathologic VP2 T cell epitope in susceptible SJL/J mice.
TLDR
This study identifies a 13 amino acid peptide on VP2 (VP2(74-86)) as the immunodominant T cell epitope in TMEV-infected and -immunized SJL/J mice, and demonstrates the ability of that sequence to prime for the majority of the SJl/J DTH T cell response to intact TMEv.
Oxidized phosphatidylcholine is a marker for neuroinflammation in multiple sclerosis brain
TLDR
The novel presence of oxidized phosphatidylcholine, a lipid associated with inflammatory diseases such as atherosclerosis and lung disease, in the brain of MS patients is reported and it is suggested that this could play a role in the progression of MS.
Interferon-gamma-oligodendrocyte interactions in the regulation of experimental autoimmune encephalomyelitis.
TLDR
It is found that IFN-gamma pretreatment of mature oligodendrocytes in vitro had a protective effect against oxidative stress and the inhibition of proteasome activity and resulted in upregulation in expression of a number of chemokines.
Interferon-γ-Oligodendrocyte Interactions in the Regulation of Experimental Autoimmune Encephalomyelitis
TLDR
It is found that IFN-γ pretreatment of mature oligodendrocytes in vitro had a protective effect against oxidative stress and the inhibition of proteasome activity and resulted in upregulation in expression of a number of chemokines.
Overexpression of Akt (protein kinase B) confers protection against apoptosis and prevents formation of ceramide in response to pro‐apoptotic stimuli
TLDR
Overexpression of PI3K (p110) and Akt protected cells against ceramide‐induced apoptosis, suggesting that Ceramide action is upstream of Akt in these cells and suggesting that Akt might be a target for inhibition by ceramide.
Does ceramide play a role in neural cell apoptosis?
TLDR
The evidence for ceramide's role in apoptosis in cells of the nervous system is considered and it is shown that depending on the target cell, ceramide induces diverse biological responses including apoptosis, cell‐cycle arrest, differentiation, and also proliferation.
Central Nervous System Expression of Interferon Regulatory Factor 1 Regulates Experimental Autoimmune Encephalomyelitis
TLDR
It is concluded that the CNS expression of IRF-1 regulates the disease process in EAE, which is relevant to the inflammatory mechanisms involved in multiple sclerosis and may provide a basis for development of novel therapeutic targets of the disease.
Functional analysis of glucocorticoid and insulin response sequences in the rat insulin-like growth factor-binding protein-1 promoter.
TLDR
A GRE is identified in the 5'-promoter region of the rat IGFBP-1 gene approximately 90 bp up-stream from the RNA cap site as well as a contiguous 22-bp region that plays a critical role in mediating the effects of insulin on glucocorticoid-stimulated promoter activity.
Cyclic AMP Protects Against Staurosporine and Wortmannin‐Induced Apoptosis and Opioid‐Enhanced Apoptosis in Both Embryonic and Immortalized (F‐11κ7) Neurons
TLDR
The opioid enhancement of apoptosis is based on the inhibition of adenylate cyclase and that the effect is time‐dependent, and the specificity for cyclic AMP was confirmed.
Acid sphingomyelinase and inhibition by phosphate ion: role of inhibition by phosphatidyl‐myo‐inositol 3,4,5‐triphosphate in oligodendrocyte cell signaling
TLDR
It is proposed that the small amount of ASMase activity associated with detergent‐resistant cell membranes (Rafts) is regulated by PtdIns(3,4,5)P3 and is most likely involved in receptor clustering and capping.
...
1
2
3
4
...