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Differential solubilization of lipids along with membrane proteins by different classes of detergents.
It is believed that differential solubilization of lipids, as well as proteins, by detergents is important for the biological activity of the extracted proteins, and lipid extractability should be taken into account when purifying membrane proteins.
Staurosporine Induces Programmed Cell Death in Embryonic Neurons and Activation of the Ceramide Pathway
The data suggest that the formation of ceramide from sphingomyelin is a key event in staurosporine‐induced and potentially all programmed cell death.
Neurochemical Characteristics of a Novel Dorsal Root Ganglion X Neuroblastoma Hybrid Cell Line, F‐11
F‐ll cells should, therefore, prove useful as models for authentic DRG neurons, and be grown under conditions in which they showed a much more extensive neuronal morphology, exhibiting many long neurites.
Oxidized phosphatidylcholine is a marker for neuroinflammation in multiple sclerosis brain
The novel presence of oxidized phosphatidylcholine, a lipid associated with inflammatory diseases such as atherosclerosis and lung disease, in the brain of MS patients is reported and it is suggested that this could play a role in the progression of MS.
Topographical distribution of complex carbohydrates in the erythrocyte membrane.
  • T. Steck, G. Dawson
  • Medicine, Chemistry
    The Journal of biological chemistry
  • 10 April 1974
All of the glycoprotein and glycolipid sugars reactive with galactose oxidase plus tritiated borohydride can be assigned to the external surface of the membrane.
Palmitoyl Protein Thioesterase 1 Protects Against Apoptosis Mediated by Ras—Akt—Caspase Pathway in Neuroblastoma Cells
The studies suggest that protein palmitoylation could be a physiological regulator of apoptosis.
Overexpression of Akt (protein kinase B) confers protection against apoptosis and prevents formation of ceramide in response to pro‐apoptotic stimuli
Overexpression of PI3K (p110) and Akt protected cells against ceramide‐induced apoptosis, suggesting that Ceramide action is upstream of Akt in these cells and suggesting that Akt might be a target for inhibition by ceramide.
Phorbol esters and PKC signaling regulate proliferation, vimentin cytoskeleton assembly and glutamine synthetase activity of chick embryo cerebrum astrocytes in culture.
It is established that TPA (PKC) regulates assembly of vimentin into the cytoskeleton of astrocytes, and 20 min treatment with TPA leads to a 3-fold increase in the rate of newly synthesized full-length vimentsin assembly (posttranslational assembly).
Neuronal ceroid lipofuscinosis with DNAJC5/CSPα mutation has PPT1 pathology and exhibit aberrant protein palmitoylation
A functional link is established between two forms of NCL and this work demonstrates that CSPα is depalmitoylated by PPT1 and hence its substrate, and establishes a functional link between two NCL disease pathways.
A lysosomal storage disorder in mice characterized by a dual deficiency of sphingomyelinase and glucocerebrosidase.
The phenotypic manifestations in these metabolically mutated animals are compared with those in Niemann-Pick disease and Gaucher's disease in humans.