simvastatin acid

Known as: Simvastatin Carboxylic Acid, 1-Naphthaleneheptanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-beta,delta-dihydroxy-2,6-dimethyl-, (1S-(1alpha(betaS*,deltaS*),2alpha,6beta,8beta,8aalpha))-, Tenivastatin 
 
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
AIMS This study aimed to investigate possible effects of the ABCG2 c.421C>A (p.Gln141Lys; rs2231142) genotype on fluvastatin… (More)
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Review
2008
Review
2008
HMG-CoA reductase inhibitors (statins) dose-dependently lower both the level of low-density lipoprotein cholesterol and risk of… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND AND OBJECTIVE Organic anion transporting polypeptide 1B1 (OATP1B1) is an uptake transporter located at the sinusoidal… (More)
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2006
2006
Cholesterol lowering statin drugs are the most frequently prescribed agents for reducing morbidity and mortality related to… (More)
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Highly Cited
2004
Highly Cited
2004
The main purpose of this work is to prepare self-microemulsifying drug delivery system (SMEDDS) for oral bioavailability… (More)
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Highly Cited
2003
Highly Cited
2003
AIMS To identify the cytochrome P450 (CYP) isoforms responsible for the metabolism of simvastatin hydroxy acid (SVA), the most… (More)
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2003
2003
The aim of this study was to examine the effect of carbamazepine on the pharmacokinetics of orally administered simvastatin in… (More)
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Highly Cited
2002
Highly Cited
2002
This study investigated the metabolic interaction between fibrates and statin hydroxy acids in human hepatocytes. Gemfibrozil… (More)
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2000
2000
BACKGROUND Rifampin (rifampicin) is a potent inducer of several cytochrome P450 (CYP) enzymes, including CYP3A4. The cholesterol… (More)
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Highly Cited
1998
Highly Cited
1998
BACKGROUND Simvastatin is a cholesterol-lowering agent that is metabolized through CYP3A4. We studied the effect of grapefruit… (More)
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