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simvastatin acid

Known as: Simvastatin Carboxylic Acid, 1-Naphthaleneheptanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-beta,delta-dihydroxy-2,6-dimethyl-, (1S-(1alpha(betaS*,deltaS*),2alpha,6beta,8beta,8aalpha))-, Tenivastatin 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (2)

LovastatinSimvastatin

Narrower (1)

Zocor
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
Impact of ABCG2 and SLCO1B1 polymorphisms on pharmacokinetics of rosuvastatin, atorvastatin and simvastatin acid in Caucasian and Asian subjects: a class effect?
Systemic exposure to rosuvastatin is approximately double that of Caucasians in Asian subjects. We investigated whether this… 
Highly Cited
2010
Highly Cited
2010
The characteristics and mechanism of simvastatin loaded lipid nanoparticles to increase oral bioavailability in rats.
Highly Cited
2009
Highly Cited
2009
Different effects of the ABCG2 c.421C>A SNP on the pharmacokinetics of fluvastatin, pravastatin and simvastatin.
AIMS This study aimed to investigate possible effects of the ABCG2 c.421C>A (p.Gln141Lys; rs2231142) genotype on fluvastatin… 
Highly Cited
2008
Highly Cited
2008
ABCB1 Haplotypes Differentially Affect the Pharmacokinetics of the Acid and Lactone Forms of Simvastatin and Atorvastatin
ABCB1 haplotypes were determined in 534 healthy Finnish volunteers, of whom 24 participated in a pharmacokinetic study on… 
Highly Cited
2004
Highly Cited
2004
Comparative pharmacokinetic interaction profiles of pravastatin, simvastatin, and atorvastatin when coadministered with cytochrome P450 inhibitors.
Highly Cited
2004
Highly Cited
2004
The effect of gemfibrozil on the pharmacokinetics of rosuvastatin
Highly Cited
2000
Highly Cited
2000
Plasma concentrations of active simvastatin acid are increased by gemfibrozil
Concomitant treatment with simvastatin and gemfibrozil, two lipid‐lowering drugs, has been associated with occurrence of myopathy… 
Highly Cited
2000
Highly Cited
2000
Duration of effect of grapefruit juice on the pharmacokinetics of the CYP3A4 substrate simvastatin
Grapefruit juice is a potent inhibitor of CYP3A4‐mediated drug metabolism. We wanted to investigate how long the inhibitory… 
Highly Cited
1998
Highly Cited
1998
Simvastatin but not pravastatin is very susceptible to interaction with the CYP3A4 inhibitor itraconazole
Review
1993
Review
1993
Clinical Pharmacokinetics and Practical Applications of Simvastatin
SummarySince simvastatin is metabolised by the cytochrome P450 system, a potential for drug interactions exists. Elevated HMG-CoA… 
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