sepantronium bromide

Known as: 1H-Naphth(2,3-d)imidazolium, 4,9-dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazinylmethyl)-, Bromide 
A small-molecule proapoptotic agent with potential antineoplastic activity. Sepantronium bromide selectively inhibits survivin expression in tumor… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2012-2018
024620122018

Papers overview

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2015
2015
Despite aggressive chemotherapy, approximately one-third of children with acute myeloid leukaemia (AML) relapse. More effective… (More)
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2014
2014
Survivin is overexpressed in transitional cell carcinoma (TCC), the most common type of bladder cancer. Previous reports… (More)
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2014
2014
Sepantronium bromide (YM155) exhibits time-dependent antitumor activity, although the plasma half-life of YM155 after a bolus… (More)
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2014
2014
The inhibitor-of-apoptosis family member survivin has been reported to inhibit apoptosis and regulate mitosis and cytokinesis. In… (More)
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2014
2014
Sepantronium bromide (YM155) is administered by 168-hour continuous infusions in clinical studies due to its time-dependent… (More)
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2013
2013
BACKGROUND This phase I/II study examined the safety and efficacy of Sepantronium Bromide (S), a small-molecule selective… (More)
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2013
2013
Triple-negative breast cancer (TNBC) has a poor prognosis compared to other subtypes, and effective treatment options are limited… (More)
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2012
2012
In the treatment of B-cell non-Hodgkin lymphoma (B-NHL) rituximab improves long-term survival in combination with conventional… (More)
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2012
2012
The purpose of this analysis was to investigate the pharmacokinetics (PK) of sepantronium (YM155), a small-molecule suppressor of… (More)
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2012
2012
Purpose Population pharmacokinetics (PK) of sepantronium bromide (YM155) was characterized in patients with non-small cell lung… (More)
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