N. Oku

Publications447
h-index57
Citations12,190
Highly Influential Citations248
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Tyrosine Phosphorylation of β-Catenin and Plakoglobin Enhanced by Hepatocyte Growth Factor and Epidermal Growth Factor in Human Carcinoma Cells
TLDR
The results suggest that HGF/SF and EGF may modulate cadherin-mediated adhesion of human carcinoma cells and β-Catenin, plakoglobin and an unidentified 115-kDa molecule associated with E-cadherin were found to be phosphorylated at tyrosine residues, and these phosphorylations were enhanced by the growth factor treatments.
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Arachidonic acid-selective cytosolic phospholipase A2 is crucial in the cytotoxic action of tumor necrosis factor.
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Anxiety-like behavior of young rats after 2-week zinc deprivation
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Zinc homeostasis in the brain of adult rats fed zinc‐deficient diet
TLDR
The present finding demonstrates that zinc homeostasis in the brain is altered by chronically zinc deprivation, and indicates that the adult brain is responsive to dietary zinc deprivation.
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Long-circulating liposomes.
  • N. Oku, Y. Namba
  • Biology
    Critical reviews in therapeutic drug carrier…
  • 1994
TLDR
This review shows examples and discusses the mechanism of RES avoidance by these modifiers of liposomes, with special focus on the glucuronide as a modifier.
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Anti-neovascular therapy by use of tumor neovasculature-targeted long-circulating liposome.
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(-)-Epigallocatechin gallate inhibits membrane-type 1 matrix metalloproteinase, MT1-MMP, and tumor angiogenesis.
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Antiangiogenic photodynamic therapy (PDT) by using long-circulating liposomes modified with peptide specific to angiogenic vessels.
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Tyrosine phosphorylation of beta-catenin and plakoglobin enhanced by hepatocyte growth factor and epidermal growth factor in human carcinoma cells.
TLDR
The results suggest that HGF/SF and EGF may modulate the function of the cadherin-catenin system via tyrosine phosphorylation of cadhersin-associated proteins.
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Recognition, neutralization, and clearance of target peptides in the bloodstream of living mice by molecularly imprinted polymer nanoparticles: a plastic antibody.
TLDR
In vivo imaging of the polymer nanoparticles established that the NPs accelerate clearance of the peptide from blood and accumulate in the liver, which offers the potential for neutralizing a wide range of biomacromolecules in vivo.
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