N. Oku

Publications440
h-index54
Citations11,253
Highly Influential Citations229
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Tyrosine Phosphorylation of β-Catenin and Plakoglobin Enhanced by Hepatocyte Growth Factor and Epidermal Growth Factor in Human Carcinoma Cells
The effect of hepatocyte growth factor /scatter factor (HGF/SF) and epidermal growth factor (EGF) on cadherin-mediated adhesion of human carcinoma cells was studied. HGF/SF induced scattering of… Expand
Anxiety-like behavior of young rats after 2-week zinc deprivation
The relationship between neuronal function in the brain and neuropsychological behavior were analyzed in young rats fed a zinc-deficient diet for 1-2 weeks. Serum zinc concentration was less than 50%… Expand
Arachidonic acid-selective cytosolic phospholipase A2 is crucial in the cytotoxic action of tumor necrosis factor.
The role of phospholipase A2 (PLA2) in the cytotoxic action of tumor necrosis factor (TNF) was examined. Recently, we described the characterization of TNF-resistant sublines isolated from… Expand
Anti-neovascular therapy by use of tumor neovasculature-targeted long-circulating liposome.
For the purpose of cancer anti-neovascular therapy (ANET), we previously isolated 5-mer peptide Ala-Pro-Arg-Pro-Gly (APRPG) that specifically bound to the tumor angiogenic site and observed that… Expand
(-)-Epigallocatechin gallate inhibits membrane-type 1 matrix metalloproteinase, MT1-MMP, and tumor angiogenesis.
Membrane-type 1 matrix metalloproteinase (MT1-MMP), which hydrolyzes type I collagen and activates MMP-2, are deeply involved in angiogenesis as well as in tumor cell invasion and metastasis. We… Expand
Long-circulating liposomes.
  • N. Oku, Y. Namba
  • Medicine
  • Critical reviews in therapeutic drug carrier…
  • 1994
Liposomes have been investigated for use as drug carriers, and many previous studies have demonstrated enhanced efficacy of encapsulated drugs and the reduction of the side effects of drugs so… Expand
Polycation liposomes, a novel nonviral gene transfer system, constructed from cetylated polyethylenimine
A novel gene transfer system was developed by using liposomes modified with cetylated polyethylenimine (PEI, MW 600). This polycation liposome, PCL, showed remarkable transfection efficiency as… Expand
Differential effects of zinc on glutamatergic and GABAergic neurotransmitter systems in the hippocampus
Approximately 10% of total zinc in the brain exists in synaptic vesicles of glutamatergic neurons; however, the function of vesicular zinc is poorly understood. The presynaptic action of zinc against… Expand
Zinc homeostasis in the brain of adult rats fed zinc‐deficient diet
Zinc concentration and 65Zn uptake in the brain of rats fed zinc‐deficient diet for 12 weeks were examined, based on a previous finding of the impairment of learning behavior by the zinc deprivation.… Expand
Tyrosine phosphorylation of beta-catenin and plakoglobin enhanced by hepatocyte growth factor and epidermal growth factor in human carcinoma cells.
The effect of hepatocyte growth factor/scatter factor (HGF/SF) and epidermal growth factor (EGF) on cadherin-mediated adhesion of human carcinoma cells was studied. HGF/SF induced scattering of… Expand
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