survivin inhibitor YM155

Known as: YM155 
A novel proapoptotic agent with potential antineoplastic activity. Survivin inhibitor YM155 selectively inhibits survivin expression in tumor cells… (More)
National Institutes of Health

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Highly Cited
2012
Highly Cited
2012
Merkel cell polyomavirus (MCV) causes ~80% of primary and metastatic Merkel cell carcinomas (MCCs). By comparing digital… (More)
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Highly Cited
2012
Highly Cited
2012
BACKGROUND Few effective therapeutic options exist for patients with refractory diffuse large B-cell lymphoma (DLBCL). YM155 is a… (More)
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Highly Cited
2011
Highly Cited
2011
Antitumor activities of YM155, a novel small-molecule survivin suppressant, were investigated in a wide variety of human cancer… (More)
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Review
2009
Review
2009
Survivin is one of the most cancer-specific proteins identified to date, being upregulated in almost all human tumors… (More)
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Highly Cited
2009
Highly Cited
2009
PURPOSE To evaluate the antitumor activity and safety of YM155, a novel, small-molecule suppressor of survivin, as single-agent… (More)
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Highly Cited
2009
Highly Cited
2009
PURPOSE YM155, a novel molecular targeted agent, suppresses survivin, a member of the inhibitor of apoptosis protein family that… (More)
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Highly Cited
2009
Highly Cited
2009
Melanoma continues to be a major health problem with no effective therapy. Melanocytes, both benign and malignant, express many… (More)
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Highly Cited
2008
Highly Cited
2008
PURPOSE To determine the maximum-tolerated dose (MTD) and assess the safety, pharmacokinetics, and preliminary evidence of… (More)
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Highly Cited
2008
Highly Cited
2008
PURPOSE Survivin, a member of the inhibitor of apoptosis protein family, is an attractive target for cancer therapy. We have now… (More)
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Highly Cited
2007
Highly Cited
2007
Various accumulating evidence suggests that survivin, a member of the inhibitor of apoptosis (IAP) family, plays an important… (More)
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