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sematilide

National Institutes of Health

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3 relations

Broader (2)

Anti-Arrhythmia AgentsProcainamide
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
In vitro detection of cardiotoxins or neurotoxins affecting ion channels or pumps using beating cardiomyocytes as alternative for animal testing.
Review
2008
Review
2008
Relationship among amiodarone, new class III antiarrhythmics, miscellaneous agents and acquired long QT syndrome.
Class III drugs prolong the QT interval by blocking mainly the delayed rectifier rapid potassium outward current (IKr), with… 
2005
2005
Halothane sensitizes the canine heart to pharmacological IKr blockade.
1999
1999
Relationship between myocardial cation content and injury in reperfused rat hearts treated with cation channel blockers.
1996
1996
Antiarrhythmic and proarrhythmic effects of sematilide in canine ventricular arrhythmia models.
Using canine ventricular arrhythmia models induced by two-stage coronary ligation, digitalis, adrenaline, coronary ligation and… 
1993
1993
Antiarrhythmic effects of selective prolongation of refractoriness. Electrophysiologic actions of sematilide HCl in humans.
BACKGROUND Recent data have suggested that antiarrhythmic agents that act largely by delaying conduction may not be as effective… 
Highly Cited
1993
Highly Cited
1993
Membrane activity of class III antiarrhythmic compounds; a comparison between ibutilide, d-sotalol, E-4031, sematilide and dofetilide.
1992
1992
Electropharmacology of dofetilide, a new class III agent, in anaesthetised dogs.
1991
1991
Cellular Electrophysiological Effects of the Class III Antiarrhythmic Agents Sematilide and Clofilium on Rabbit Atrial Tissues
Sematilide (N-[2-(diethylamino)ethyl]-4-[(methylsulfonyl)amino]benzamide HCl) is a new class III antiarrhythmic agent that has… 
Highly Cited
1990
Highly Cited
1990
Suppression of repolarization-related arrhythmias in vitro and in vivo by low-dose potassium channel activators.
Marked prolongation of cardiac action potentials and of QT intervals has been associated with early afterdepolarizations and… 
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