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sazetidine-A

National Institutes of Health

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2 relations

Broader (2)

AzetidinesPyridines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Oral sazetidine-A, a selective α4β2* nicotinic receptor desensitizing agent, reduces nicotine self-administration in rats
2018
2018
Mutually augmenting interactions of dextromethorphan and sazetidine-A for reducing nicotine self-administration in rats
2017
2017
Differential efficacies of the nicotinic α4β2 desensitizing agents in reducing nicotine self-administration in female rats
Desensitization of neuronal nicotinic acetylcholine receptors holds promise as an effective treatment of tobacco addiction… 
2017
2017
The Effects of Sazetidine-A on Alcohol and Nicotine Consumption in Mice
2014
2014
Chronic sazetidine‐A maintains anxiolytic effects and slower weight gain following chronic nicotine without maintaining increased density of nicotinic receptors in rodent brain
Chronic nicotine administration increases the density of brain α4β2* nicotinic acetylcholine receptors (nAChRs), which may… 
2014
2014
Synthesis and pharmacological characterization of new neuronal nicotinic acetylcholine receptor ligands derived from Sazetidine-A.
2013
2013
Chemistry and pharmacological studies of 3-alkoxy-2,5-disubstituted-pyridinyl compounds as novel selective α4β2 nicotinic acetylcholine receptor ligands that reduce alcohol intake in rats.
Neuronal acetylcholine receptors mediate the addictive effects of nicotine and may also be involved in alcohol addiction… 
2013
2013
Effects of the sazetidine-a family of compounds on the body temperature in wildtype, nicotinic receptor β2-/- and α7-/- mice.
2012
2012
Chronic Sazetidine-A at Behaviorally Active Doses Does Not Increase Nicotinic Cholinergic Receptors in Rodent Brain
Chronic nicotine administration increases α4β2 neuronal nicotinic acetylcholine receptor (nAChR) density in brain. This up… 
2012
2012
Effects of chronic sazetidine-A, a selective α4β2 neuronal nicotinic acetylcholine receptors desensitizing agent on pharmacologically-induced impaired attention in rats
Nicotine and nicotinic agonists have been shown to improve attentional function. Nicotinic receptors are easily desensitized, and… 
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