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saperconazole

Known as: (+-)-1-sec-Butyl-4-(p-(4-(p-(((2R*,4S*)-2-(2,4-difluorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-1-piperazinyl)phenyl)-delta(sup 2)-1,2,4-triazolin-5-one, 3H-1,2,4-Triazol-3-one, 4-(4-(4-(4-((2-(2,4-difluorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-1-piperazinyl)phenyl)-2,4-dihydro-2-(1-methylpropyl)-, SPZ 
A synthetic broad-spectrum fluorinated triazole with potential antifungal activity. Saperconazole preferentially inhibits fungal cytochrome P450… 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

Antifungal AgentsAzoles

Narrower (1)

R 66905

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2013
Review
2013
The whole parasite, pre-erythrocytic stage approach to malaria vaccine development: a review
Purpose of review The whole sporozoite (SPZ) vaccine platform provides the only established approach for inducing high-level… 
2009
2009
Sulfaphenazole protects heart against ischemia-reperfusion injury and cardiac dysfunction by overexpression of iNOS, leading to enhancement of nitric oxide bioavailability and tissue oxygenation.
The objective of this study was to establish the cardioprotective effect of sulfaphenazole (SPZ), a selective inhibitor of… 
2004
2004
Transcurrent continental tectonics model for the Ossa-Morena Zone Neoproterozoic–Paleozoic evolution, SW Iberian Massif, Portugal
The Ossa-Morena Zone (SW Iberian Massif) was affected by continuous orogen-parallel transcurrent continental tectonics from the… 
1996
1996
Importance of calcium for the binding of oviductal fluid proteins to the membranes of bovine spermatozoa
Our laboratory has recently shown that in vitro‐cultured oviductal cells secrete sperm motility maintaining factor(s). Since the… 
1994
1994
Saperconazole therapy of murine disseminated candidiasis: efficacy and interactions with amphotericin B
The efficacy of a new triazole antifungal agent, saperconazole, in a murine model of disseminated candidiasis was studied. Mice… 
1993
1993
A preliminary study of in vitro antibiotic activity of saperconazole and other azoles on Paracoccidioides brasiliensis.
Saperconazole, a new triazole related to itraconazole, was tested against Paracoccidioides brasiliensis and results compared with… 
1992
1992
Monoisoamyl meso-2,3-dimercaptosuccinate: interaction with metallothionein-bound cadmium in vitro and evidence of active transport into renal and hepatic cells in vivo.
Monoisoamyl meso-2,3-dimercaptosuccinate (Mi-ADMS) and the unesterified 2,3-dimercaptosuccinic acid (DMSA) were evaluated for… 
1990
1990
Saperconazole: A selective inhibitor of the cytochrome P‐450‐dependent ergosterol synthesis in Candida albicans, Aspergillus fumigatus and Trichophyton mentagrophytes
The N‐1‐substituted triazole antifungal, saperconazole, is a potent inhibitor of ergosterol synthesis in Candida albicans… 
1989
1989
Structural degeneration of Aspergillus fumigatus after exposure to saperconazole.
Saperconazole is a newly synthesized triazole antifungal with potent activity against Aspergillus fumigatus. Exposure of spores… 
1985
1985
Mechanisms of hypouricemia in the syndrome of inappropriate secretion of antidiuretic hormone.
Hypouricemia seen with hyponatremia related to the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) results… 
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