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Chemotherapy-induced and/or radiation therapy-induced oral mucositis--complicating the treatment of cancer.
Mucositis is one of the most common adverse reactions encountered in radiation therapy for head and neck cancers, as well as in chemotherapy, in particular with drugs affecting DNA synthesis (S-phase-specific agents such as fluorouracil, methotrexate, and cytarabine).
Protective effect of Spirulina against doxorubicin‐induced cardiotoxicity
Pretreatment with Spirulina significantly protected mice from DOX‐induced cardiotoxic effects as evidenced from lower mortality, less ascites, lower levels of lipid peroxidation, normalization of antioxidant enzymes and ultrastructural studies showing minimal damage to the heart.
Pharmacological Preconditioning of Mesenchymal Stem Cells with Trimetazidine (1-[2,3,4-Trimethoxybenzyl]piperazine) Protects Hypoxic Cells against Oxidative Stress and Enhances Recovery of Myocardial
A significant increase in the recovery of myocardial function and up-regulation of pAkt and Bcl-2 levels were observed in hearts transplanted with TMZ-preconditioned cells.
Spirulina attenuates cyclosporine‐induced nephrotoxicity in rats
It is suggested that Spirulina has a protective effect against nephrotoxicity induced by CsA, and this study further supports the crucial role of the antioxidant nature of SpirulINA in protecting againstCsA‐induced oxidative stress.
Protective effect of CardiPro against doxorubicin-induced cardiotoxicity in mice.
Protection against cisplatin-induced nephrotoxicity by Spirulina in rats
In vitro studies using human ovarian cancer cells revealed that Spirulina did not interfere with the cytotoxic effects of CP on tumor cells, and protected the rats from CP-induced nephrotoxicity through its antioxidant properties.