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Sodium N-methyl-D-glucamine dithiocarbamate and cadmium intoxication.
A single intraperitoneal injection of sodium N-methyl-D-glucamine dithiocarbamate (NaNMG-DTC), administered at a level greater than 1.1 mmol/kg body weight, protects against a normally lethal dose of cadmium chloride and results in a subsequent dose-dependent decrease in the liver and kidney burdens of Cadmium ion. Expand
In vivo studies of cadmium-induced apoptosis in testicular tissue of the rat and its modulation by a chelating agent.
Characteristic DNA migration patterns (laddering) provide evidence of apoptosis (programmed cell death) in testicular tissue of rats administered CdCl2 at a level of 0.03 mmol/kg 48 h previously. Expand
In vivo spin trapping of nitric oxide in mice.
An in vivo spin-trapping technique combined with electron paramagnetic resonance (EPR) spectroscopy to measure nitric oxide (.NO) production in the blood circulation of conscious mice represents the first spin trapping of .NO in living animals. Expand
Antagonists for acute oral cadmium chloride intoxication.
By far the most effective in both enhancing survival and leaving minimal residual levels of cadmium in the liver and the kidney, was meso-2,3-dimercaptosuccinic acid (DMSA), while several polyaminocarboxylic acids also enhanced survival. Expand
Optimal dithiocarbamate structure for immunomodulator action.
Chemical evidence suggests that other dithiocarbamates which are more stable at pH 7.4 might prove to be quite superior for the treatment of AIDS patients, and these can be expected to be superior to DEDTC, especially for oral administration. Expand
Influence of Rate of Development of Leaf Water Deficits upon Photosynthesis, Leaf Conductance, Water Use Efficiency, and Osmotic Potential in Sorghum
The conclusion reached that stomatal closure occurs slowly over a wide range of leaf water potential (> 1.0 MPa), the range being greater for slower rates of stress. Expand
Effect of chelate treatments on kidney, bone and brain lead levels of lead-intoxicated mice.
An examination of published data describing the effect of chelating agent treatment onbrain lead levels indicates that DMSA produces a reduction in brain lead levels under all conditions examined to date. Expand
Aluminium distribution and excretion: a comparative study of a number of chelating agents in rats.
Assessment in rats of the comparative effects of a number of chelating agents on the urinary excretion and tissue distribution of A1 found that only treatment with 1-(p-chlorobenzyl)-2-methyl-3-hydroxypyrid-4-one and 1-benzyl-2-ethyl- 3-Hydroxypryid- 4-one significantly reduced A1 concentrations in all analyzed tissues. Expand
Work in progress: potential oral and intravenous paramagnetic NMR contrast agents.
NMR has the potential to detect differences in tissue oxygenation by incorporating paramagnetic metal ions into insoluble compounds or stable complexes, toxicity can be dramatically reduced while maintaining a significant paramagnetic effect. Expand
Osmotic adjustment in leaves of sorghum in response to water deficits.
  • M. Jones
  • Biology, Medicine
  • Plant physiology
  • 1978
From the relationship between turgor potential and relative water content there was an approximate doubling of the volumetric elastic modulus, i.e. a halving of tissue elasticity, as a result of stress preconditioning. Expand