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sapacitabine

Known as: 2'-C-cyano-2'-deoxy-1-arabinofuranosyl-N(4)-palmitoylcytosine, CNDAC cpd, N-(1-(2-Cyano-2-deoxy-beta-D-arabinofuranosyl)-2-oxo-1,2-dihydropyrimidin-4-yl)-hexadecanamide 
An orally bioavailable pyrimidine analogue prodrug with potential antineoplastic activity. Sapacitabine is hydrolyzed by amidases to the… Expand
National Institutes of Health

Papers overview

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2017
2017
2'-C-cyano-2'-deoxy-1-β-d-arabino-pentofuranosylcytosine (CNDAC) is the active metabolite of the anticancer drug, sapacitabine… Expand
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Review
2017
Review
2017
More than half of the patients with acute myeloid leukaemia (AML) are older than 60years. The treatment outcomes in this group… Expand
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Review
2016
Review
2016
Activation of checkpoint arrest and homologous DNA repair are necessary for maintenance of genomic integrity during DNA… Expand
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2016
2016
Purpose: The double-strand breaks elicited by sapacitabine, a clinically active nucleoside analogue prodrug, are repaired by… Expand
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2015
2015
The development of new treatments for older patients with acute myeloid leukaemia (AML) is an active area, but has met with… Expand
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2012
2012
BACKGROUND Available treatments for acute myeloid leukaemia (AML) have limited durable activity and unsatisfactory safety… Expand
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2012
2012
Sapacitabine is an orally bioavailable prodrug of the nucleoside analog 2′-C-cyano-2′-deoxy-1-β-D-arabino-pentofuranosylcytosine… Expand
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2010
2010
PURPOSE Sapacitabine is an oral deoxycytidine nucleoside analog with a unique mechanism of action that is different from… Expand
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2008
2008
Causing damage to angiogenic vessels is a promising approach for cancer chemotherapy. The present study is a codification of a… Expand
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2007
2007
This study assessed the antiproliferative activity of sapacitabine (CYC682, CS-682) in a panel of 10 human cancer cell lines with… Expand
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