retaspimycin hydrochloride

Known as: 17-Allylamino-17-demethoxygeldanamycin hydroquinone hydrochloride, Geldanamycin, 18,21-didehydro-17-demethoxy-18,21-dideoxo-18,21-dihydroxy-17-(2-propenylamino)-, monohydrochloride 
The hydrochloride salt of a small-molecule inhibitor of heat shock protein 90 (HSP90) with antiproliferative and antineoplastic activities… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2009-2013
024620092013

Papers overview

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2013
2013
PURPOSE Heat shock protein 90 (HSP90) is required for the proper folding, function, and stability of various client proteins, two… (More)
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2011
2011
OBJECTIVE To evaluate clinical activity and safety of retaspimycin hydrochloride (IPI-504) in patients with castration-resistant… (More)
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2011
2011
Abstract A phase 1 study of IPI-504 (retaspimycin hydrochloride) administered intravenously twice weekly for 2 weeks at 22.5… (More)
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2011
2011
The activity of the receptor tyrosine kinase KIT is crucial for gastrointestinal stromal tumor (GIST) growth and survival… (More)
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2011
2011
7516 Background: IPI-504, a water-soluble analog of 17-allylamino-17-demethoxygeldanamycin (17-AAG), is an intravenously (IV… (More)
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Review
2011
Review
2011
590 Background: Retaspimycin hydrochloride (IPI-504) is a potent, intravenously-administered heat shock protein 90 (Hsp90… (More)
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2009
2009
3547 Background: IPI-504 is a water-soluble heat shock protein 90 (Hsp90) inhibitor. IPI-504 causes the degradation of a variety… (More)
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2009
2009
e14539 Background: Heat shock protein 90 (Hsp90) is a protein chaperone that regulates the proper folding, stability, and… (More)
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Review
2009
Review
2009
8073 Background: IPI-504 (retaspimycin hydrochloride) is a potent, water-soluble heat shock protein 90 (Hsp90) inhibitor. IPI-504… (More)
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Review
2009
Review
2009
The ansamycin class of natural products is well known for its anti-tumor effects and has been extensively studied by cancer… (More)
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