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retaspimycin hydrochloride

Known as: 17-Allylamino-17-demethoxygeldanamycin hydroquinone hydrochloride, Geldanamycin, 18,21-didehydro-17-demethoxy-18,21-dideoxo-18,21-dihydroxy-17-(2-propenylamino)-, monohydrochloride 
The hydrochloride salt of a small-molecule inhibitor of heat shock protein 90 (HSP90) with antiproliferative and antineoplastic activities… 
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Purpose: Heat shock protein 90 (HSP90) is required for the proper folding, function, and stability of various client proteins… 
2011
2011
Abstract A phase 1 study of IPI-504 (retaspimycin hydrochloride) administered intravenously twice weekly for 2 weeks at 22.5, 45… 
Review
2011
Review
2011
590 Background: Retaspimycin hydrochloride (IPI-504) is a potent, intravenously-administered heat shock protein 90 (Hsp90… 
2011
2011
The activity of the receptor tyrosine kinase KIT is crucial for gastrointestinal stromal tumor (GIST) growth and survival… 
Review
2009
Review
2009
Heat shock proteins are vital to cell survival under conditions of stress. They bind client proteins to assist in protein… 
Review
2009
Review
2009
8073 Background: IPI-504 (retaspimycin hydrochloride) is a potent, water-soluble heat shock protein 90 (Hsp90) inhibitor. IPI-504… 
2009
2009
3547 Background: IPI-504 is a water-soluble heat shock protein 90 (Hsp90) inhibitor. IPI-504 causes the degradation of a variety… 
Review
2009
Review
2009
The ansamycin class of natural products is well known for its anti-tumor effects and has been extensively studied by cancer… 
Highly Cited
2006
Highly Cited
2006
Heat shock protein 90 (Hsp90) is an emerging therapeutic target of interest for the treatment of cancer. Its role in protein…