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Purpose: Heat shock protein 90 (HSP90) is required for the proper folding, function, and stability of various client proteins… Expand OBJECTIVE
To evaluate clinical activity and safety of retaspimycin hydrochloride (IPI-504) in patients with castration-resistant… Expand Abstract A phase 1 study of IPI-504 (retaspimycin hydrochloride) administered intravenously twice weekly for 2 weeks at 22.5, 45… Expand The activity of the receptor tyrosine kinase KIT is crucial for gastrointestinal stromal tumor (GIST) growth and survival… Expand Giuseppe Floris, Maria Debiec-Rychter, Agnieszka Wozniak, Cristiana Stefan, Emmanuel Normant, Gavino Faa, Kathleen Machiels, Ulla… Expand 7516 Background: IPI-504, a water-soluble analog of 17-allylamino-17-demethoxygeldanamycin (17-AAG), is an intravenously (IV… Expand Heat shock proteins are vital to cell survival under conditions of stress. They bind client proteins to assist in protein… Expand 3547 Background: IPI-504 is a water-soluble heat shock protein 90 (Hsp90) inhibitor. IPI-504 causes the degradation of a variety… Expand The ansamycin class of natural products is well known for its anti-tumor effects and has been extensively studied by cancer… Expand Heat shock protein 90 (Hsp90) is an emerging therapeutic target of interest for the treatment of cancer. Its role in protein… Expand