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retaspimycin hydrochloride

Known as: 17-Allylamino-17-demethoxygeldanamycin hydroquinone hydrochloride, Geldanamycin, 18,21-didehydro-17-demethoxy-18,21-dideoxo-18,21-dihydroxy-17-(2-propenylamino)-, monohydrochloride 
The hydrochloride salt of a small-molecule inhibitor of heat shock protein 90 (HSP90) with antiproliferative and antineoplastic activities… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Purpose: Heat shock protein 90 (HSP90) is required for the proper folding, function, and stability of various client proteins… Expand
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2011
2011
OBJECTIVE To evaluate clinical activity and safety of retaspimycin hydrochloride (IPI-504) in patients with castration-resistant… Expand
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2011
2011
Abstract A phase 1 study of IPI-504 (retaspimycin hydrochloride) administered intravenously twice weekly for 2 weeks at 22.5, 45… Expand
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2011
2011
7516 Background: IPI-504, a water-soluble analog of 17-allylamino-17-demethoxygeldanamycin (17-AAG), is an intravenously (IV… Expand
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2011
2011
The activity of the receptor tyrosine kinase KIT is crucial for gastrointestinal stromal tumor (GIST) growth and survival… Expand
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2011
2011
Giuseppe Floris, Maria Debiec-Rychter, Agnieszka Wozniak, Cristiana Stefan, Emmanuel Normant, Gavino Faa, Kathleen Machiels, Ulla… Expand
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2010
2010
7517 Background: Oncogenic ALK gene rearrangements (rALK) recently have been identified in approximately 3-5% of all NSCLC… Expand
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2009
2009
3547 Background: IPI-504 is a water-soluble heat shock protein 90 (Hsp90) inhibitor. IPI-504 causes the degradation of a variety… Expand
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2009
2009
e14539 Background: Heat shock protein 90 (Hsp90) is a protein chaperone that regulates the proper folding, stability, and… Expand
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Highly Cited
2006
Highly Cited
2006
Heat shock protein 90 (Hsp90) is an emerging therapeutic target of interest for the treatment of cancer. Its role in protein… Expand
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