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IPI 504

Known as: IPI-504, IPI504 
A small-molecule inhibitor of heat shock protein 90 (HSP90) with antiproliferative and antineoplastic activity. IPI-504 binds to and inhibits the… Expand
National Institutes of Health

Related topics

Related topics

2 relations
retaspimycin hydrochloride

Broader (1)

tanespimycin

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
A Phase I Study of the HSP90 Inhibitor Retaspimycin Hydrochloride (IPI-504) in Patients with Gastrointestinal Stromal Tumors or Soft-Tissue Sarcomas
Purpose: Heat shock protein 90 (HSP90) is required for the proper folding, function, and stability of various client proteins… Expand
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Highly Cited
2013
Highly Cited
2013
A multicenter trial evaluating retaspimycin HCL (IPI-504) plus trastuzumab in patients with advanced or metastatic HER2-positive breast cancer
Heat shock protein 90 (Hsp90) facilitates maturation and stability of HER2. Combining an Hsp90 inhibitor and trastuzumab has… Expand
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Highly Cited
2011
Highly Cited
2011
The Hsp90 inhibitor IPI-504 overcomes bortezomib resistance in mantle cell lymphoma in vitro and in vivo by down-regulation of the prosurvival ER chaperone BiP/Grp78.
Despite the promising introduction of the proteasome inhibitor bortezomib in the treatment of mantle cell lymphoma (MCL), not all… Expand
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Highly Cited
2011
Highly Cited
2011
The Hsp90 inhibitor IPI-504 rapidly lowers EML4–ALK levels and induces tumor regression in ALK-driven NSCLC models
Heat shock protein 90 (Hsp90) is an emerging target for cancer therapy due to its important role in maintaining the activity and… Expand
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Highly Cited
2011
Highly Cited
2011
Exploiting cancer cell vulnerabilities to develop a combination therapy for ras-driven tumors.
Ras-driven tumors are often refractory to conventional therapies. Here we identify a promising targeted therapeutic strategy for… Expand
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Highly Cited
2010
Highly Cited
2010
Activity of IPI-504, a novel heat-shock protein 90 inhibitor, in patients with molecularly defined non-small-cell lung cancer.
PURPOSE IPI-504 is a novel, water-soluble, potent inhibitor of heat-shock protein 90 (Hsp90). Its potential anticancer activity… Expand
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Highly Cited
2008
Highly Cited
2008
Activity of Dasatinib, a Dual SRC/ABL Kinase Inhibitor, and IPI-504, a Heat Shock Protein 90 Inhibitor, against Gastrointestinal Stromal Tumor–Associated PDGFRAD842V Mutation
Purpose: Activating mutations in platelet-derived growth factor receptor-α (PDGFRA) have been reported in ∼5% to 10% of patients… Expand
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Highly Cited
2008
Highly Cited
2008
Antitumor activity and molecular effects of the novel heat shock protein 90 inhibitor, IPI-504, in pancreatic cancer
Targeting Hsp90 is an attractive strategy for anticancer therapy because the diversity and relevance of biological processes are… Expand
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Highly Cited
2008
Highly Cited
2008
Inhibition of heat shock protein 90 (Hsp90) with the novel agent IPI-504 in metastatic GIST following failure of tyrosine kinase inhibitors (TKIs) or other sarcomas: Clinical results from phase I…
10503 Background: Laboratory studies have demonstrated that inhibition of the Hsp90 chaperone protein results in selective… Expand
Highly Cited
2006
Highly Cited
2006
Development of 17-allylamino-17-demethoxygeldanamycin hydroquinone hydrochloride (IPI-504), an anti-cancer agent directed against Hsp90
Heat shock protein 90 (Hsp90) is an emerging therapeutic target of interest for the treatment of cancer. Its role in protein… Expand
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