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IPI 504

Known as: IPI-504, IPI504 
A small-molecule inhibitor of heat shock protein 90 (HSP90) with antiproliferative and antineoplastic activity. IPI-504 binds to and inhibits the… Expand
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Purpose: Heat shock protein 90 (HSP90) is required for the proper folding, function, and stability of various client proteins… Expand
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Highly Cited
2013
Highly Cited
2013
Heat shock protein 90 (Hsp90) facilitates maturation and stability of HER2. Combining an Hsp90 inhibitor and trastuzumab has… Expand
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Highly Cited
2011
Highly Cited
2011
Despite the promising introduction of the proteasome inhibitor bortezomib in the treatment of mantle cell lymphoma (MCL), not all… Expand
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Highly Cited
2011
Highly Cited
2011
Heat shock protein 90 (Hsp90) is an emerging target for cancer therapy due to its important role in maintaining the activity and… Expand
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Highly Cited
2011
Highly Cited
2011
Ras-driven tumors are often refractory to conventional therapies. Here we identify a promising targeted therapeutic strategy for… Expand
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Highly Cited
2010
Highly Cited
2010
PURPOSE IPI-504 is a novel, water-soluble, potent inhibitor of heat-shock protein 90 (Hsp90). Its potential anticancer activity… Expand
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Highly Cited
2008
Highly Cited
2008
Purpose: Activating mutations in platelet-derived growth factor receptor-α (PDGFRA) have been reported in ∼5% to 10% of patients… Expand
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Highly Cited
2008
Highly Cited
2008
Targeting Hsp90 is an attractive strategy for anticancer therapy because the diversity and relevance of biological processes are… Expand
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Highly Cited
2008
Highly Cited
2008
10503 Background: Laboratory studies have demonstrated that inhibition of the Hsp90 chaperone protein results in selective… Expand
Highly Cited
2006
Highly Cited
2006
Heat shock protein 90 (Hsp90) is an emerging therapeutic target of interest for the treatment of cancer. Its role in protein… Expand
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