IPI 504

Known as: IPI-504, IPI504 
A small-molecule inhibitor of heat shock protein 90 (HSP90) with antiproliferative and antineoplastic activity. IPI-504 binds to and inhibits the… (More)
National Institutes of Health

Papers overview

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2013
2013
Heat shock protein 90 (Hsp90) facilitates maturation and stability of HER2. Combining an Hsp90 inhibitor and trastuzumab has… (More)
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Highly Cited
2011
Highly Cited
2011
Heat shock protein 90 (Hsp90) is an emerging target for cancer therapy due to its important role in maintaining the activity and… (More)
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Highly Cited
2011
Highly Cited
2011
Despite the promising introduction of the proteasome inhibitor bortezomib in the treatment of mantle cell lymphoma (MCL), not all… (More)
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Highly Cited
2011
Highly Cited
2011
Ras-driven tumors are often refractory to conventional therapies. Here we identify a promising targeted therapeutic strategy for… (More)
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2011
2011
Hsp90 facilitates the maturation and stability of numerous oncoproteins, including HER2. The aim of this study was to assess the… (More)
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Highly Cited
2010
Highly Cited
2010
PURPOSE IPI-504 is a novel, water-soluble, potent inhibitor of heat-shock protein 90 (Hsp90). Its potential anticancer activity… (More)
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Highly Cited
2008
Highly Cited
2008
PURPOSE Activating mutations in platelet-derived growth factor receptor-alpha (PDGFRA) have been reported in approximately 5% to… (More)
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2008
2008
Targeting Hsp90 is an attractive strategy for anticancer therapy because the diversity and relevance of biological processes are… (More)
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2007
2007
BackgroundInhibitors of heat shock protein (Hsp) 90 induce apoptosis in multiple myeloma (MM) cells, but the molecular mechanisms… (More)
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Highly Cited
2006
Highly Cited
2006
Heat shock protein 90 (Hsp90) is an emerging therapeutic target of interest for the treatment of cancer. Its role in protein… (More)
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