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tanespimycin

Known as: 17-AAG, 17-(allylamino)-17-demethoxy-geldanamycin, 17AAG 
A benzoquinone antineoplastic antibiotic derived from the antineoplastic antibiotic geldanamycin. Tanespimycin binds to and inhibits the cytosolic… Expand
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
BackgroundThere is overwhelming evidence that in vitro three-dimensional tumor cell cultures more accurately reflect the complex… Expand
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Highly Cited
2011
Highly Cited
2011
PURPOSE HSP90 is a chaperone protein required for the stability of a variety of client proteins. 17-Demethoxygeldanamycin (17-AAG… Expand
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Highly Cited
2011
Highly Cited
2011
Multiple myeloma (MM) cells are characterized by high protein synthesis resulting in chronic endoplasmic reticulum (ER) stress… Expand
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Highly Cited
2011
Highly Cited
2011
The tight control of wild-type p53 by mainly MDM2 in normal cells is permanently lost in tumors harboring mutant p53, which… Expand
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Highly Cited
2005
Highly Cited
2005
Heat-shock protein 90 (Hsp90) functions as part of a multichaperone complex that folds, activates and assembles its client… Expand
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Highly Cited
2005
Highly Cited
2005
Hsp90 is a ubiquitously expressed molecular chaperone that folds, stabilizes, and functionally regulates many cellular proteins… Expand
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Review
2004
Review
2004
The multichaperone heat shock protein (Hsp) 90 complex mediates the maturation and stability of a variety of proteins, many of… Expand
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Highly Cited
2003
Highly Cited
2003
Heat shock protein 90 (Hsp90) is a molecular chaperone that plays a key role in the conformational maturation of oncogenic… Expand
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Review
2002
Review
2002
Current anticancer drug development strategies involve identifying novel molecular targets which are crucial for tumourigenesis… Expand
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Highly Cited
2001
Highly Cited
2001
HL-60/Bcr-Abl cells, with ectopic expression of p185 Bcr-Abl tyrosine kinase (TK), and K562 cells, with endogenous expression of… Expand
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