tanespimycin

Known as: 17-AAG, 17-(allylamino)-17-demethoxy-geldanamycin, 17AAG 
A benzoquinone antineoplastic antibiotic derived from the antineoplastic antibiotic geldanamycin. Tanespimycin binds to and inhibits the cytosolic… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1995-2018
05019952018

Papers overview

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Highly Cited
2012
Highly Cited
2012
There is overwhelming evidence that in vitro three-dimensional tumor cell cultures more accurately reflect the complex in vivo… (More)
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Highly Cited
2011
Highly Cited
2011
PURPOSE HSP90 is a chaperone protein required for the stability of a variety of client proteins. 17-Demethoxygeldanamycin (17-AAG… (More)
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Highly Cited
2011
Highly Cited
2011
The echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) fusion oncogene represents a… (More)
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Highly Cited
2007
Highly Cited
2007
PURPOSE This phase I study examined whether a heat shock protein (Hsp) 90 inhibitor tanespimycin (17-AAG; KOS-953) could be… (More)
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Highly Cited
2006
Highly Cited
2006
We show that multiple myeloma (MM), the second most commonly diagnosed hematologic malignancy, is responsive to hsp90 inhibitors… (More)
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Highly Cited
2005
Highly Cited
2005
PURPOSE To study the toxicity and pharmacokinetic-pharmacodynamic profile of 17-allylamino, 17- demethoxygeldanamycin (17-AAG… (More)
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Highly Cited
2005
Highly Cited
2005
Heat-shock protein 90 (Hsp90) functions as part of a multichaperone complex that folds, activates and assembles its client… (More)
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Highly Cited
2003
Highly Cited
2003
Heat shock protein 90 (Hsp90) is a molecular chaperone that plays a key role in the conformational maturation of oncogenic… (More)
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Highly Cited
2002
Highly Cited
2002
PURPOSE Ansamycin antibiotics, including 17allylamino-17-demethoxygeldanamycin (17-AAG), inhibit Hsp90 function and cause the… (More)
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Highly Cited
1998
Highly Cited
1998
Purpose: Benzoquinone ansamycins are antibiotics with anticancer potential. First described as tyrosine kinase inhibitors, they… (More)
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