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tanespimycin

Known as: 17-AAG, 17-(allylamino)-17-demethoxy-geldanamycin, 17AAG 
A benzoquinone antineoplastic antibiotic derived from the antineoplastic antibiotic geldanamycin. Tanespimycin binds to and inhibits the cytosolic… 
National Institutes of Health

Related topics

Related topics

16 relations
17-N-allylamino-17-demethoxygeldanamycin/imatinib mesylate17-N-allylamino-17-demethoxygeldanamycin/sorafenibHSP90 Heat-Shock ProteinsNCIt Antineoplastic Agent Terminology

Narrower (8)

17-allylamino-17-demethoxygeldanamycin hydroquinone17-allylaminogeldanamycinCNF1010IPI 493

Broader (2)

BenzoquinonesLactams, Macrocyclic

Papers overview

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Highly Cited
2008
Highly Cited
2008
Inhibition of Hsp90 down-regulates mutant epidermal growth factor receptor (EGFR) expression and sensitizes EGFR mutant tumors to paclitaxel.
Mutations in the kinase domain of the epidermal growth factor receptor (EGFR) are found in a subset of patients with lung cancer… 
Review
2006
Review
2006
Targeting of multiple signalling pathways by heat shock protein 90 molecular chaperone inhibitors.
The last decade has seen the molecular chaperone heat shock protein 90 (HSP90) emerge as an exciting target for cancer therapy… 
Highly Cited
2005
Highly Cited
2005
Antimyeloma activity of heat shock protein-90 inhibition.
We show that multiple myeloma (MM), the second most commonly diagnosed hematologic malignancy, is responsive to hsp90 inhibitors… 
Review
2004
Review
2004
Combinatorial attack on multistep oncogenesis by inhibiting the Hsp90 molecular chaperone.
Review
2004
Review
2004
Geldanamycin as a Potential Anti-Cancer Agent: Its Molecular Target and Biochemical Activity
Heat shock protein 90 is one of the most abundantcellularproteins. Although its functions are still being characterized,itappears… 
Highly Cited
2003
Highly Cited
2003
Inhibition of heat shock protein 90 function down-regulates Akt kinase and sensitizes tumors to Taxol.
The phosphatidylinositol 3'-kinase/Akt pathway is activated frequently in human cancer, and has been implicated in tumor… 
Review
2003
Review
2003
Clinical development of 17-allylamino, 17-demethoxygeldanamycin.
17-allylamino, 17-demethoxygeldanamycin (17AAG; NSC 330507) is the first modulator of heat shock protein 90 (Hsp90) to enter… 
Highly Cited
2002
Highly Cited
2002
Geldanamycin induces degradation of hypoxia-inducible factor 1alpha protein via the proteosome pathway in prostate cancer cells.
Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription factor composed of alpha and beta subunits. HIF-1 is… 
Highly Cited
2000
Highly Cited
2000
Gene expression profiling of human colon cancer cells following inhibition of signal transduction by 17-allylamino-17-demethoxygeldanamycin, an inhibitor of the hsp90 molecular chaperone
A number of molecular therapeutic agents, derived from exploiting our knowledge of the oncogenic pathways that are frequently… 
Highly Cited
1998
Highly Cited
1998
The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin
Purpose: Benzoquinone ansamycins are antibiotics with anticancer potential. First described as tyrosine kinase inhibitors, they… 
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