Skip to search formSkip to main contentSkip to account menu

tanespimycin

Known as: 17-AAG, 17-(allylamino)-17-demethoxy-geldanamycin, 17AAG 
A benzoquinone antineoplastic antibiotic derived from the antineoplastic antibiotic geldanamycin. Tanespimycin binds to and inhibits the cytosolic… 
National Institutes of Health

Related topics

Related topics

16 relations
17-N-allylamino-17-demethoxygeldanamycin/imatinib mesylate17-N-allylamino-17-demethoxygeldanamycin/sorafenibHSP90 Heat-Shock ProteinsNCIt Antineoplastic Agent Terminology

Narrower (8)

17-allylamino-17-demethoxygeldanamycin hydroquinone17-allylaminogeldanamycinCNF1010IPI 493

Broader (2)

BenzoquinonesLactams, Macrocyclic

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Identification of epipolythiodioxopiperazines HDN-1 and chaetocin as novel inhibitor of heat shock protein 90
The molecular chaperone heat shock protein 90 (Hsp90) has emerged as an important target for cancer treatment. HDN-1, an… 
Highly Cited
2013
Highly Cited
2013
A Phase I Study of the HSP90 Inhibitor Retaspimycin Hydrochloride (IPI-504) in Patients with Gastrointestinal Stromal Tumors or Soft-Tissue Sarcomas
Purpose: Heat shock protein 90 (HSP90) is required for the proper folding, function, and stability of various client proteins… 
Review
2011
Review
2011
Heat Shock Protein as Molecular Targets for Breast Cancer Therapeutics
Recent advances in the understanding of the molecular mechanisms involved in the breast cancer development and progression have… 
Highly Cited
2011
Highly Cited
2011
Heat Shock Protein 90 Inhibitor Is Synergistic with JAK2 Inhibitor and Overcomes Resistance to JAK2-TKI in Human Myeloproliferative Neoplasm Cells
Purpose: We determined the activity of hsp90 inhibitor, and/or Janus-activated kinase 2 (JAK2) tyrosine kinase inhibitor (TKI… 
Highly Cited
2008
Highly Cited
2008
A Phase I Study of 17-Allylamino-17-Demethoxygeldanamycin Combined with Paclitaxel in Patients with Advanced Solid Malignancies
Background: 17-Allylamino-17-demethoxygeldanamycin (17-AAG) inhibits heat shock protein 90, promotes degradation of oncoproteins… 
Highly Cited
2008
Highly Cited
2008
A Phase 1 Dose-Escalation Study of Irinotecan in Combination with 17-Allylamino-17-Demethoxygeldanamycin in Patients with Solid Tumors
Purpose: Both heat shock protein 90 (Hsp90) and checkpoint kinase 1 (Chk1) have emerged as novel therapeutic targets. We… 
Highly Cited
2006
Highly Cited
2006
Pharmacological induction of Hsp70 protects apoptosis-prone cells from doxorubicin: comparison with caspase-inhibitor- and cycle-arrest-mediated cytoprotection
Selective modulation of cell death is important for rational chemotherapy. By depleting Hsp90-client oncoproteins, geldanamycin… 
Review
2006
Review
2006
Effectiveness of hsp90 inhibitors as anti-cancer drugs.
Hsp90 is a chaperone with over 100 identified client proteins. What makes Hsp90 especially promising as a target for anti-cancer… 
Highly Cited
2002
Highly Cited
2002
Nucleophosmin-anaplastic lymphoma kinase (NPM-ALK), a novel Hsp90-client tyrosine kinase: down-regulation of NPM-ALK expression and tyrosine phosphorylation in ALK(+) CD30(+) lymphoma cells by the…
Anaplastic large cell lymphomas (ALCL) are characterized by the expression of a chimeric protein, NPM-ALK, which originates from… 
Highly Cited
2001
Highly Cited
2001
Enhancement of paclitaxel-mediated cytotoxicity in lung cancer cells by 17-allylamino geldanamycin: in vitro and in vivo analysis.
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)