17-allylaminogeldanamycin

Known as: 17-allylamino-geldanamycin 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2001-2018
02420012018

Papers overview

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2011
2011
5582 Background: 17-allylaminogeldanamycin (17-AAG) is a benzoquinone ansamycin antibiotic that destabilizes heat shock protein… (More)
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2007
Highly Cited
2007
Hypoxia-inducible factor 1 (HIF-1) regulates transcription in response to changes in O(2) concentration. O(2)-dependent… (More)
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2007
2007
PURPOSE To determine the recommended phase 2 dose, dose-limiting toxicities (DLT), pharmacokinetic profile, and pharmacodynamics… (More)
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2006
2006
The Hsp90 inhibitor 17-allylaminogeldanamycin (17-AAG), which is currently in clinical trials, is thought to exert antitumor… (More)
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2005
2005
The differential toxicity of two anticancer agents is described using the in vitro rat liver slice culture model. Liver slices… (More)
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2004
Highly Cited
2004
The development of therapeutic inhibitors of key signaling pathways has been hampered by the inability to assess the effect of a… (More)
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2003
Highly Cited
2003
Heat shock protein 90 (Hsp90) is a molecular chaperone that plays a key role in the conformational maturation of oncogenic… (More)
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2002
Highly Cited
2002
Clinical resistance to imatinib mesylate is commonly observed in patients with advanced Philadelphia chromosome- positive (Ph… (More)
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Highly Cited
2002
Highly Cited
2002
Ansamycin antibiotics, such as 17-allylaminogeldanamycin (17-AAG), bind to Hsp90 and regulate its function, resulting in the… (More)
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2001
2001
Steroid hormone receptors have become an important target in the management of breast cancers. Despite a good initial response… (More)
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