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17-allylaminogeldanamycin

Known as: 17-allylamino-geldanamycin 
 
National Institutes of Health

Papers overview

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2011
2011
1. Increasing evidence indicates that hydrogen sulphide (H2S) may serve as an important biological cytoprotective agent. Heat… Expand
Highly Cited
2007
Highly Cited
2007
Hypoxia-inducible factor 1 (HIF-1) regulates transcription in response to changes in O(2) concentration. O(2)-dependent… Expand
Highly Cited
2007
Highly Cited
2007
Purpose: To determine the recommended phase 2 dose, dose-limiting toxicities (DLT), pharmacokinetic profile, and pharmacodynamics… Expand
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Highly Cited
2006
Highly Cited
2006
The Hsp90 inhibitor 17-allylaminogeldanamycin (17-AAG), which is currently in clinical trials, is thought to exert antitumor… Expand
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Review
2005
Review
2005
  • Y. Miyata
  • Current pharmaceutical design
  • 2005
  • Corpus ID: 33434212
Geldanamycin, an ansamycin-derivative benzoquinone compound, was originally isolated as a natural product with anti-fungal… Expand
Highly Cited
2004
Highly Cited
2004
The development of therapeutic inhibitors of key signaling pathways has been hampered by the inability to assess the effect of a… Expand
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Highly Cited
2003
Highly Cited
2003
Heat shock protein 90 (Hsp90) is a molecular chaperone that plays a key role in the conformational maturation of oncogenic… Expand
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Review
2002
Review
2002
  • L. Neckers
  • Trends in molecular medicine
  • 2002
  • Corpus ID: 19290452
Heat shock protein 90 (Hsp90) is a molecular chaperone whose association is required for the stability and function of multiple… Expand
Highly Cited
2002
Highly Cited
2002
Ansamycin antibiotics, such as 17-allylaminogeldanamycin (17-AAG), bind to Hsp90 and regulate its function, resulting in the… Expand
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Highly Cited
2002
Highly Cited
2002
Clinical resistance to imatinib mesylate is commonly observed in patients with advanced Philadelphia chromosome- positive (Ph… Expand
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