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17-allylaminogeldanamycin

Known as: 17-allylamino-geldanamycin 
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
Hypoxia-inducible factor 1 (HIF-1) regulates transcription in response to changes in O(2) concentration. O(2)-dependent… 
Highly Cited
2007
Highly Cited
2007
Purpose: To determine the recommended phase 2 dose, dose-limiting toxicities (DLT), pharmacokinetic profile, and pharmacodynamics… 
Review
2005
Review
2005
  • Y. Miyata
  • Current pharmaceutical design
  • 2005
  • Corpus ID: 33434212
Geldanamycin, an ansamycin-derivative benzoquinone compound, was originally isolated as a natural product with anti-fungal… 
Review
2004
Review
2004
Highly Cited
2004
Highly Cited
2004
The development of therapeutic inhibitors of key signaling pathways has been hampered by the inability to assess the effect of a… 
Highly Cited
2003
Highly Cited
2003
Heat shock protein 90 (Hsp90) is a molecular chaperone that plays a key role in the conformational maturation of oncogenic… 
Review
2002
Review
2002
  • L. Neckers
  • Trends in molecular medicine
  • 2002
  • Corpus ID: 19290452
Highly Cited
2002
Highly Cited
2002
Clinical resistance to imatinib mesylate is commonly observed in patients with advanced Philadelphia chromosome- positive (Ph… 
Highly Cited
2002
Highly Cited
2002
Ansamycin antibiotics, such as 17-allylaminogeldanamycin (17-AAG), bind to Hsp90 and regulate its function, resulting in the…