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renzapride

Known as: 4-amino-5-chloro-2-methoxy-N-(1-azabicyclo-(3.3.1)-non-4-yl)benzamide, Benzamide, 4-amino-N-1-azabicyclo(3.3.1)non-4-yl-5-chloro-2-methoxy-, monohydrochloride, endo-(+-)- 
 
National Institutes of Health

Related topics

Related topics

4 relations

Narrower (1)

BRL 24924

Broader (3)

BenzamidesBridged Bicyclo Compounds, HeterocyclicSerotonin Antagonists

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Clinical trial: renzapride treatment of women with irritable bowel syndrome and constipation - a double-blind, randomized, placebo-controlled, study.
BACKGROUND Renzapride, a 5-hydroxytryptamine type-4 (5-HT(4)) receptor agonist and 5-HT(3) receptor antagonist, has been proposed… Expand
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2008
2008
Clinical trial: renzapride therapy for constipation-predominant irritable bowel syndrome--multicentre, randomized, placebo-controlled, double-blind study in primary healthcare setting.
BACKGROUND Relatively few pharmacological treatment options are available for treating patients with irritable bowel syndrome… Expand
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2006
2006
Pilot study of the efficacy of renzapride on gastrointestinal motility and symptoms in patients with constipation-predominant irritable bowel syndrome.
AIM To investigate the efficacy and safety of renzapride, a potent 5-hydroxytryptamine type-4 receptor full agonist and 5… Expand
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Review
2005
Review
2005
Basic and clinical pharmacology of new motility promoting agents.
Recent research has provided new information about drugs that could be used to treat functional motility disorders. Promotility… Expand
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Highly Cited
2004
Highly Cited
2004
Effect of renzapride on transit in constipation-predominant irritable bowel syndrome.
BACKGROUND & AIMS The aim of this study was to evaluate the dose-ranging pharmacodynamic effects of renzapride, a 5… Expand
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Highly Cited
1998
Highly Cited
1998
Cloning, expression, and pharmacology of four human 5-hydroxytryptamine 4 receptor isoforms produced by alternative splicing in the carboxyl terminus.
We report here the molecular cloning of three new splice variants of the human serotonin 5-hydroxytryptamine4 (h5-HT4) receptor… Expand
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Highly Cited
1994
Highly Cited
1994
5-HT1A and 5-HT4 receptors mediate inhibition and facilitation of fast synaptic transmission in enteric neurons.
The actions of 5-hydroxtryptamine (5-HT)1A and 5-HT4 receptor agonists on fast excitatory postsynaptic potentials (EPSPs) in… Expand
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Highly Cited
1992
Highly Cited
1992
Serotonin increases calcium current in human atrial myocytes via the newly described 5-hydroxytryptamine4 receptors.
In various species, including humans, 5-hydroxytryptamine (5-HT) has been shown to exert positive chronotropic and inotropic… Expand
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1991
1991
The effects of renzapride, a novel prokinetic agent, in diabetic gastroparesis.
Gastric emptying was measured in 9 diabetic patients with autonomic neuropathy (Group 1) and 8 normal controls (Group 2) on 4… Expand
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1991
1991
Peristalsis evoked by 5-HT and renzapride: evidence for putative 5-HT4 receptor activation.
The effect of 5-hydroxytryptamine and renzapride was studied on the peristaltic reflex elicited in vitro in the guinea-pig ileum… Expand
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