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Transgenic mouse lines are characterized with Cre recombinase driven by promoters of CNS-specific genes using bacterial… Expand ABSTRACT Staphylococcal cassette chromosome mec (SCCmec) is a mobile genetic element composed of the mec gene complex, which… Expand Site-specific recombinase systems (Cre-loxP, Flp-FRT, and phi C31-att) are transforming both forward and reverse genetics in mice… Expand Summary: We have used a Prx1 limb enhancer to drive expression of Cre Recombinase in transgenic mice. This regulatory element… Expand We have developed a simple and highly efficient method to disrupt chromosomal genes in Escherichia coli in which PCR primers… Expand Summary: As conditional genetic strategies advance, the need for multiple site‐specific recombinase systems has emerged. To meet… Expand The ability to generate specific genetic modifications in mice provides a powerful approach to assess gene function. When genetic… Expand Ligand-dependent chimeric Cre recombinases are powerful tools to induce specific DNA rearrangements in cultured cells and in mice… Expand We have transferred the site-specific recombination system of the yeast 2 micron plasmid, the FLP recombinase and its… Expand The Cre protein encoded by the coliphage P1 is a 38-kDa protein that efficiently promotes both intra- and intermolecular synapsis… Expand