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MerCreMer recombinase

 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

Recombinant Fusion Proteinsrecombinase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Voluntary Exercise Improves Cardiac Function and Prevents Cardiac Remodeling in a Mouse Model of Dilated Cardiomyopathy
Objective: Despite the indubitable beneficial effect of exercise to prevent of cardiovascular diseases, there is still a lack of… Expand
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2013
2013
Direct, Differential Effects of Tamoxifen, 4-Hydroxytamoxifen, and Raloxifene on Cardiac Myocyte Contractility and Calcium Handling
Tamoxifen (Tam), a selective estrogen receptor modulator, is in wide clinical use for the treatment and prevention of breast… Expand
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Highly Cited
2013
Highly Cited
2013
Moderate and high amounts of tamoxifen in αMHC-MerCreMer mice induce a DNA damage response, leading to heart failure and death
SUMMARY Numerous mouse models have utilized Cre-loxP technology to modify gene expression. Adverse effects of Cre recombinase… Expand
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Review
2013
Review
2013
Cardiac fibrosis in mice expressing an inducible myocardial-specific Cre driver
SUMMARY Tamoxifen-inducible Cre-mediated manipulation of animal genomes has achieved wide acceptance over the last decade, with… Expand
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2012
2012
Induction of Native Cardiomyocyte Cell Cycle Re-Entry by Transplanted Cells as a Novel Mechanism of Therapeutic Regeneration in the Heart
Background: The extent of cardiomyocyte (CM) turnover in adult mammals remains unclear, while controversy surrounds the putative… Expand
2010
2010
Reduced SERCA2 abundance decreases the propensity for Ca2+ wave development in ventricular myocytes.
AIMS To describe the overall role of reduced sarcoplasmic reticulum Ca(2+) ATPase (SERCA2) for Ca(2+) wave development. METHODS… Expand
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2010
2010
Genetic fate-mapping for studying adult cardiomyocyte replenishment after myocardial injury.
Mounting evidence suggests the regenerative potential of the mammalian heart. Nevertheless, the contribution of endogenous stem… Expand
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