Millisecond-timescale, genetically targeted optical control of neural activity
- E. Boyden, Feng Zhang, E. Bamberg, G. Nagel, K. Deisseroth
- BiologyNature Neuroscience
- 1 September 2005
Temporally precise, noninvasive control of activity in well-defined neuronal populations is a long-sought goal of systems neuroscience. We adapted for this purpose the naturally occurring algal…
Driving fast-spiking cells induces gamma rhythm and controls sensory responses
The timing of a sensory input relative to a gamma cycle determined the amplitude and precision of evoked responses and provided the first causal evidence that distinct network activity states can be induced in vivo by cell-type-specific activation.
Parvalbumin neurons and gamma rhythms enhance cortical circuit performance
- V. Sohal, Feng Zhang, O. Yizhar, K. Deisseroth
- BiologyNature
- 4 June 2009
Optogenetics opens the door to a new kind of informational analysis of brain function, permitting quantitative delineation of the functional significance of individual elements in the emergent operation and function of intact neural circuitry.
Structural and molecular interrogation of intact biological systems
- K. Chung, J. Wallace, K. Deisseroth
- BiologyNature
- 16 May 2013
It is shown that CLARITY enables fine structural analysis of clinical samples, including non-sectioned human tissue from a neuropsychiatric-disease setting, establishing a path for the transmutation of human tissue into a stable, intact and accessible form suitable for probing structural and molecular underpinnings of physiological function and disease.
Neocortical excitation/inhibition balance in information processing and social dysfunction
- O. Yizhar, Lief E. Fenno, K. Deisseroth
- Biology, PsychologyNature
- 8 September 2011
Elevation, but not reduction, of cellular E/I balance within the mouse medial prefrontal cortex was found to elicit a profound impairment in cellular information processing, associated with specific behavioural impairments and increased high-frequency power in the 30–80 Hz range, which have both been observed in clinical conditions in humans.
Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry
- A. Kravitz, Benjamin Freeze, A. Kreitzer
- Biology, PsychologyNature
- 29 July 2010
These findings establish a critical role for basal ganglia circuitry in the bidirectional regulation of motor behaviour and indicate that modulation of direct-pathway circuitry may represent an effective therapeutic strategy for ameliorating parkinsonian motor deficits.
Optogenetics in Neural Systems
- O. Yizhar, Lief E. Fenno, Thomas J. Davidson, Murtaza Z Mogri, K. Deisseroth
- BiologyNeuron
- 14 July 2011
Optical Deconstruction of Parkinsonian Neural Circuitry
- V. Gradinaru, Murtaza Z Mogri, K. Thompson, J. Henderson, K. Deisseroth
- BiologyScience
- 17 April 2009
This work used optogenetics and solid-state optics to systematically drive or inhibit an array of distinct circuit elements in freely moving parkinsonian rodents and found that therapeutic effects within the subthalamic nucleus can be accounted for by direct selective stimulation of afferent axons projecting to this region.
CREB Phosphorylation and Dephosphorylation: A Ca2+- and Stimulus Duration–Dependent Switch for Hippocampal Gene Expression
- H. Bito, K. Deisseroth, R. Tsien
- BiologyCell
- 27 December 1996
Genetic dissection of an amygdala microcircuit that gates conditioned fear
- W. Haubensak, Prabhat S. Kunwar, David J. Anderson
- Biology, PsychologyNature
- 11 November 2010
Molecular genetic approaches are used to map the functional connectivity of a subpopulation of GABA-containing neurons, located in the lateral subdivision of the central amygdala (CEl), which express protein kinase C-δ (PKC- δ) and define an inhibitory microcircuit in CEl that gates CEm output to control the level of conditioned freezing.
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