recombinant human thrombopoietin

Known as: rhTPO, thrombopoietin, recombinant human, Recombinant Human TPO 
 
National Institutes of Health

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4 relations
THPO genecytarabine/idarubicin/recombinant human thrombopoietin

Broader (2)

ThrombopoietinThrombopoietin, human

Papers overview

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2009
2009
Comparative analyses of the small molecule thrombopoietin receptor agonist eltrombopag and thrombopoietin on in vitro platelet function.
OBJECTIVE The thrombopoietin receptor (TPOR) is a therapeutic target for treatment of thrombocytopenia because stimulation of… (More)
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2003
2003
Importance of predosing of recombinant human thrombopoietin to reduce chemotherapy-induced early thrombocytopenia.
PURPOSE Recombinant human thrombopoietin (rhTPO) increases platelets, and the peak response of rhTPO is delayed and is, therefore… (More)
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Review
2002
Review
2002
Recombinant human thrombopoietin: basic biology and evaluation of clinical studies.
Thrombocytopenia is a common medical problem for which the main treatment is platelet transfusion. Given the increasing use of… (More)
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2000
2000
Recombinant Human Thrombopoietin Attenuates Carboplatin-Induced Severe Thrombocytopenia and the Need for Platelet Transfusions in Patients with Gynecologic Cancer.
Myelosuppression is a serious complication in patients who are receiving chemotherapy for cancer. The use of myeloid growth… (More)
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Review
2000
Review
2000
Clinical experience with recombinant human thrombopoietin in chemotherapy-induced thrombocytopenia.
Since the identification and cloning of c-Mpl ligand, two forms of recombinant human thrombopoietin have undergone clinical… (More)
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2000
2000
A phase I trial of recombinant human thrombopoietin in patients with delayed platelet recovery after hematopoietic stem cell transplantation.
Delayed platelet recovery is a significant complication after both autologous and allogeneic hematopoietic stem cell… (More)
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Highly Cited
1999
Highly Cited
1999
Interaction of thrombopoietin with the platelet c-mpl receptor in plasma: binding, internalization, stability and pharmacokinetics.
Thrombopoietin (TPO) is the primary regulator of platelet production and acts through binding its receptor, c-mpl, found on… (More)
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1997
1997
Human platelets as a model for the binding and degradation of thrombopoietin.
Recent studies have shown that plasma thrombopoietin (TPO) levels appear to be directly regulated by platelet mass and that… (More)
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1997
1997
Thrombin cleaves recombinant human thrombopoietin: one of the proteolytic events that generates truncated forms of thrombopoietin.
A heterogeneity in the molecular weight (Mr) of thrombopoietin (TPO) has been reported. We found several thrombin cleavage sites… (More)
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1995
1995
Growth response of acute myeloblastic leukemia cells to recombinant human thrombopoietin.
Thrombopoietin (TPO) is a newly identified hematopoietic growth factor that stimulates both megakaryopoiesis and thrombopoiesis… (More)
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