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THPO gene

Known as: Thrombopoietin Gene, MPL LIGAND, MPLLG 
This gene plays a role in promoting megakaryocytopoiesis, the cellular development process that leads to platelet production.
National Institutes of Health

Related topics

Related topics

10 relations
Cell Differentiation processCytokine Receptor BindingCytokine SignalingHematopoiesis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2001
Highly Cited
2001
Thrombopoietin therapy increases platelet yields in healthy platelet donors.
The recombinant thrombopoietins have been shown to be effective stimulators of platelet production in cancer patients. It was… 
Highly Cited
2000
Highly Cited
2000
Cytometric analysis of high shear-induced platelet microparticles and effect of cytokines on microparticle generation.
BACKGROUND Microparticles released from platelets may play a role in the normal hemostatic response to vascular injury, because… 
Highly Cited
1999
Highly Cited
1999
Thrombopoietin promotes hematopoietic recovery and survival after high-dose whole body irradiation.
Highly Cited
1998
Highly Cited
1998
Targeted expansion of genetically modified bone marrow cells.
The ability to specifically target a mitogenic signal to a population of genetically modified primary cells would have potential… 
Highly Cited
1998
Highly Cited
1998
Thrombopoietin promotes the survival of murine hematopoietic long-term reconstituting cells: comparison with the effects of FLT3/FLK-2 ligand and interleukin-6.
The effects of thrombopoietin (TPO; c-mpl ligand), FLT3/FLK-2 ligand (FL), and interleukin-6 (IL-6) on the survival of murine… 
Highly Cited
1997
Highly Cited
1997
Polyploidization and functional maturation are two distinct processes during megakaryocytic differentiation: involvement of cyclin-dependent kinase inhibitor p21 in polyploidization.
The mechanism of megakaryocytic differentiation was investigated using human megakaryocytic leukemia cell line UT-7… 
Highly Cited
1996
Highly Cited
1996
Bone marrow stromal cells produce thrombopoietin and stimulate megakaryocyte growth and maturation but suppress proplatelet formation.
Production of blood cells is regulated by the interplay of various cytokines and bone marrow stromal cells. Recently, a ligand… 
Highly Cited
1996
Highly Cited
1996
Functional regions of the mouse thrombopoietin receptor cytoplasmic domain: evidence for a critical region which is involved in differentiation and can be complemented by erythropoietin
Thrombopoietin (TPO) is the major regulator of growth and differentiation of megakaryocytes. To identify functionally important… 
Highly Cited
1995
Highly Cited
1995
Murine thrombopoietin mRNA levels are modulated by platelet count.
The activity of the c-Mpl ligand hematopoietic progenitors meets criteria expected for thrombopoietin (TPO). Bio-assays have… 
Highly Cited
1995
Highly Cited
1995
Thrombopoietin induces tyrosine phosphorylation and activation of the Janus kinase, JAK2.
Thrombopoietin (TPO) is a recently characterized growth and differentiation factor for megakaryocytes and platelets that exerts… 
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