Skip to search formSkip to main contentSkip to account menu

THPO gene

Known as: Thrombopoietin Gene, MPL LIGAND, MPLLG 
This gene plays a role in promoting megakaryocytopoiesis, the cellular development process that leads to platelet production.
National Institutes of Health

Related topics

Related topics

10 relations
Cell Differentiation processCytokine Receptor BindingCytokine SignalingHematopoiesis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
Calreticulin mutants in mice induce an MPL-dependent thrombocytosis with frequent progression to myelofibrosis.
Frameshift mutations in the calreticulin (CALR) gene are seen in about 30% of essential thrombocythemia and myelofibrosis… 
Highly Cited
2002
Highly Cited
2002
Prominent role of TGF-beta 1 in thrombopoietin-induced myelofibrosis in mice.
Several studies suggest an implication of transforming growth factor-beta1 (TGF-beta1) in the promotion of myelofibrosis… 
Highly Cited
2001
Highly Cited
2001
Mean platelet volume: a useful marker of inflammatory bowel disease activity
OBJECTIVES:We investigated whether the mean platelet volume would be a useful marker in the evaluation of inflammatory bowel… 
Highly Cited
2000
Highly Cited
2000
Expansion of human NOD/SCID-repopulating cells by stem cell factor, Flk2/Flt3 ligand, thrombopoietin, IL-6, and soluble IL-6 receptor.
Here, we demonstrate a significant ex vivo expansion of human hematopoietic stem cells capable of repopulating in NOD/SCID mice… 
Review
2000
Review
2000
Translational pathophysiology: a novel molecular mechanism of human disease.
In higher eukaryotes, the expression of about 1 gene in 10 is strongly regulated at the level of messenger RNA (mRNA) translation… 
Highly Cited
1999
Highly Cited
1999
Articular cartilage superficial zone protein (SZP) is homologous to megakaryocyte stimulating factor precursor and Is a multifunctional proteoglycan with potential growth-promoting, cytoprotective…
We have performed cDNA sequencing and homology analyses to elucidate the complete amino acid composition for a superficial zone… 
Highly Cited
1999
Highly Cited
1999
Thrombopoietin-induced activation of the mitogen-activated protein kinase (MAPK) pathway in normal megakaryocytes: role in endomitosis.
Thrombopoietin (TPO) plays a critical role in megakaryocyte proliferation and differentiation. Using various cultured cell lines… 
Highly Cited
1998
Highly Cited
1998
An activating splice donor mutation in the thrombopoietin gene causes hereditary thrombocythaemia
Essential thrombocythaemia (ET) is a chronic myeloproliferative syndrome due to sustained proliferation of megakaryocytes, which… 
Highly Cited
1996
Highly Cited
1996
Differential cytokine effects on primitive (CD34+CD38-) human hematopoietic cells: novel responses to Flt3-ligand and thrombopoietin
A high proportion of the CD34+CD38- cells in normal human marrow are defined as long-term culture-initiating cells (LTC-IC… 
Highly Cited
1996
Highly Cited
1996
Characterization of a bipotent erythro-megakaryocytic progenitor in human bone marrow.
The aim of the present study was to determine if the human erythroid (E) and megakaryocytic (MK) lineages were closely linked to… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)