THPO gene

Known as: Thrombopoietin Gene, MPL LIGAND, MPLLG 
This gene plays a role in promoting megakaryocytopoiesis, the cellular development process that leads to platelet production.
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Dysregulated Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling due to activation of tyrosine… (More)
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Highly Cited
2004
Highly Cited
2004
The molecular pathways involved in the differentiation of hematopoietic progenitors are unknown. Here we report that chemokine… (More)
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Highly Cited
2001
Highly Cited
2001
We have developed a statistical regression modeling approach to discover genes that are differentially expressed between two… (More)
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Highly Cited
2001
Highly Cited
2001
OBJECTIVES:We investigated whether the mean platelet volume would be a useful marker in the evaluation of inflammatory bowel… (More)
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Highly Cited
1996
Highly Cited
1996
Thrombopoietin (TPO), the ligand for c-mpl, stimulates proliferation of committed megakaryocytic progenitors and induces… (More)
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Highly Cited
1995
Highly Cited
1995
Despite the importance of blood platelets in health and disease, the mechanisms regulating their formation within megakaryocytes… (More)
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Highly Cited
1995
Highly Cited
1995
Thrombopoietin (Tpo), the ligand for the c-mpl receptor, is a major regulator of platelet production in vivo. Treatment of mice… (More)
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Highly Cited
1994
Highly Cited
1994
THE development of blood cells including expansion of megakaryocyte progenitor cells requires the interplay of marrow stromal… (More)
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Highly Cited
1987
Highly Cited
1987
Mechanisms of thrombocytopenia were studied in 38 patients with mild to moderately severe chronic autoimmune thrombocytopenia… (More)
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