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Bortezomib overcomes cell adhesion-mediated drug resistance through downregulation of VLA-4 expression in multiple myeloma
TLDR
Functional screening using short hairpin RNA suggests that VLA-4 plays a critical role in CAM-DR of MM cells, and the combination of bortezomib with conventional anti-myeloma drugs may be effective in overcoming CAM- DR of MM. Expand
Lineage‐specific regulation of cell cycle control gene expression during haematopoietic cell differentiation
TLDR
The results suggest that the expression of cell cycle control genes is distinctively regulated in a lineage‐dependent manner, reflecting the cell cycle characteristics of each lineage. Expand
Histone deacetylases are critical targets of bortezomib-induced cytotoxicity in multiple myeloma.
TLDR
It is shown that histone deacetylases (HDACs) are critical targets of bortezomib, which specifically down-regulated the expression of class I HDACs in MM cell lines and primary MM cells at the transcriptional level, accompanied by reciprocal histone hyperacetylation. Expand
Phosphorylation of Bcl-2 Protein by CDC2 Kinase during G2/M Phases and Its Role in Cell Cycle Regulation*
TLDR
The results suggest that two distinct functions of Bcl-2 (anti-apoptosis and cell cycle inhibition) are differentially regulated by post-translational mechanisms such as phosphorylation, which may play some physiological roles in the negative regulatory events during mitosis. Expand
Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19).
TLDR
It is demonstrated that cell lines and a primary sample of t(17;19)-ALL expressed LMO2 at significantly higher levels than other B-precursor ALLs did and could be a target for a new therapeutic modality for extremely chemo-resistant t( 17; 19)-ALL. Expand
HDAC inhibitors augment cytotoxic activity of rituximab by upregulating CD20 expression on lymphoma cells
TLDR
It is shown that histone deacetylase (HDAC) inhibitors augment the cytotoxic activity of rituximab by enhancing the surface expression of CD20 antigen on lymphoma cells. Expand
The Novel Orally Active Proteasome Inhibitor K-7174 Exerts Anti-myeloma Activity in Vitro and in Vivo by Down-regulating the Expression of Class I Histone Deacetylases*
TLDR
This study shows that K-7174, one of proteasome inhibitory homopiperazine derivatives, exhibits a therapeutic effect, which is stronger when administered orally than intravenously, without obvious side effects in a murine myeloma model, and suggests that class I HDACs are critical targets of K- 7174-induced cytotoxicity. Expand
Polyploidization and functional maturation are two distinct processes during megakaryocytic differentiation: involvement of cyclin-dependent kinase inhibitor p21 in polyploidization.
TLDR
It is proposed that megakaryocytic differentiation consists of two distinct processes, polyploidization and functional maturation, and that these two processes are independently regulated. Expand
Histone deacetylase 1 enhances microRNA processing via deacetylation of DGCR8
TLDR
It is found that histone deacetylase 1 (HDAC1) increases the expression levels of mature miRNAs despite repressing the transcription of host genes, suggesting that HDACs have two arms for gene silencing: transcriptional repression by promoter histoneDeacetylation and post‐transcriptional inhibition by increasing miRNA abundance. Expand
Transcriptional repression of the E2F-1 gene by interferon-α is mediated through induction of E2F-4/pRB and E2F-4/p130 complexes
TLDR
E2F-4 is a critical regulator of E2f-1, which offer an excellent paradigm for understanding functional diversity within the E2F family, according to the findings of this study. Expand
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